Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Tiffany K Koyano"'
Autor:
Cristiana Iosef, Albert J. Pedroza, Jason Z. Cui, Alex R. Dalal, Mamoru Arakawa, Yasushi Tashima, Tiffany K. Koyano, Grayson Burdon, Samantha M. P. Churovich, Joshua O. Orrick, Mitchel Pariani, Michael P. Fischbein
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Abstract Marfan syndrome (MFS) is a connective tissue disorder caused by mutations in the FBN1 gene that produces wide disease phenotypic variability. The lack of ample genotype–phenotype correlation hinders translational study development aimed at
Externí odkaz:
https://doaj.org/article/5f51d52d33394a82b68928fa4c927f13
Autor:
Yuanjia Zhu, Yasuhiro Shudo, Hao He, Joo Young Kim, Stefan Elde, Kiah M. Williams, Sabrina K. Walsh, Tiffany K. Koyano, Brandon Guenthart, Y. Joseph Woo
Publikováno v:
Transplantation. 107:1151-1157
The SherpaPak Cardiac Transport System is a novel technology that provides stable, optimal hypothermic control during organ transport. The objectives of this study were to describe our experience using the SherpaPak system and to compare outcomes aft
Autor:
Michael P. Fischbein, Marie Nguyen, Peter Chiu, Andrew J. Connolly, Ovijit Chaudhuri, Tiffany K Koyano, Alex R. Dalal, Hong-pyo Lee
Publikováno v:
JVS-Vascular Science
JVS-Vascular Science, Vol 2, Iss, Pp 235-246 (2021)
JVS-Vascular Science, Vol 2, Iss, Pp 235-246 (2021)
Objective: Current guidelines for prophylactic replacement of the thoracic aorta, primarily based on size alone, may not be adequate in identifying patients at risk for either progression of disease or aortic catastrophe. We undertook the current stu
Autor:
Itai Palmon, Yasushi Tashima, Paul Chang, Tiffany K Koyano, Cristiana Iosef, Grayson Burdon, Michael P. Fischbein, Jason Z. Cui, Adam J. Rubin, Jeffrey Trojan, Kevin J Jaatinen, G. Berry, Albert J. Pedroza
Publikováno v:
Journal of Cellular and Molecular Medicine
Aortic root aneurysm formation is a cardinal feature of Marfan syndrome (MFS) and likely TGF‐β driven via Smad (canonical) and ERK (non‐canonical) signalling. The current study assesses human MFS vascular smooth muscle cell (SMC) phenotype, focu
Autor:
Robyn Fong, Tiffany K Koyano, Trieu Nguyen, Manabu Nagao, Ramen Kundu, Robert C. Wirka, Milos Pjanic, John A. Coller, Rui Chang, Y. Joseph Woo, Stephen B. Montgomery, Juyong Brian Kim, Michelle D. Tallquist, Clint L. Miller, Boxiang Liu, Joseph C. Wu, Kuixi Zhu, Melissa Alamprese, David T. Paik, Thomas Quertermous, Dhananjay Wagh
Publikováno v:
Nature medicine
In response to various stimuli, vascular smooth muscle cells (SMCs) can de-differentiate, proliferate and migrate in a process known as phenotypic modulation. However, the phenotype of modulated SMCs in vivo during atherosclerosis and the influence o
Autor:
Brandon A. Guenthart, Saverio La Francessca, John W. MacArthur, Yasuhiro Shudo, William Hiesinger, Tiffany K Koyano, Joshua Chan, Aiman Alassar, Aravind Krishnan, Y. Joseph Woo
Publikováno v:
Transplantation proceedings. 53(8)
Background The donor shortage poses a major limitation to use of heart transplantation. Novel strategies such as use of expanded-criteria donors with prolonged ischemia times are being employed to address this need. Recent developments in static hypo
Autor:
Michael P. Fischbein, Cristiana Iosef, Yasushi Tashima, Grayson Burdon, Joshua O Orrick, Alex R. Dalal, Albert J. Pedroza, Tiffany K Koyano, Jason Z. Cui, Mitchel Pariani, Mamoru Arakawa, Samantha Churovich
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific Reports
Marfan syndrome (MFS) is a connective tissue disorder caused by mutations in the FBN1 gene that produces wide disease phenotypic variability. The lack of ample genotype–phenotype correlation hinders translational study development aimed at improvin
Autor:
Holden T. Maecker, Yueh-Hsiu Chen, Tiffany K Koyano, David M. Louis, Charles Chan, Jessica D’Addabbo, Jack H. Boyd, Xianxi Huang, Gunsagar S. Gulati, Koki Sasagawa, Jinliang Li, Robyn Fong, Patricia K. Nguyen, Mark M. Davis, Roshni Roy Chowdhury
Publikováno v:
Circulation. 142
Background: Despite advances in medical therapy, heart attack and stroke remain leading causes of morbidity and mortality. Biological, epidemiological, and clinical studies have shown that many patients (up to 33% in some trials) still have residual
Autor:
Cristiana Iosef, Atsushi Yamaguchi, Michael P. Fischbein, Ken Nakamura, Albert J. Pedroza, Jason Z. Cui, Nobu Yokoyama, Tiffany K Koyano, Yasushi Tashima, Hao He, Grayson Burdon
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Male patients with Marfan syndrome have a higher risk of aortic events and root dilatation compared with females. The role androgens play during Marfan syndrome aneurysm development in males remains unknown. We hypothesized that androgens
Autor:
Y. Joseph Woo, John W. MacArthur, William Hiesinger, Tiffany K Koyano, Yasuhiro Shudo, Rhodalene Benjamin-Addy
Publikováno v:
Future cardiology. 17(1)
Orthotopic heart transplantation is the gold standard treatment for end-stage heart failure. However, the persistent shortage of available donor organs has resulted in an ever-increasing waitlist and longer waiting periods for transplantation. On the