Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Tiffany J Mellott"'
Autor:
Thomas A Bellio, Jessenia Y Laguna-Torres, Mary S Campion, Jay Chou, Sheila Yee, Jan K Blusztajn, Tiffany J Mellott
Publikováno v:
PLoS ONE, Vol 19, Iss 2, p e0297289 (2024)
Alzheimer's disease (AD) is characterized by cognitive and memory impairments and neuropathological abnormalities. AD has no cure, inadequate treatment options, and a limited understanding of possible prevention measures. Previous studies have demons
Externí odkaz:
https://doaj.org/article/ccb9e7ed631a421c88df72e0ddc9514f
Autor:
Tiffany J Mellott, Olivia M Huleatt, Bethany N Shade, Sarah M Pender, Yi B Liu, Barbara E Slack, Jan K Blusztajn
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0174875 (2017)
[This corrects the article DOI: 10.1371/journal.pone.0170450.].
Externí odkaz:
https://doaj.org/article/fd11d2ebe93a44a38261666c73f0ac51
Autor:
Tiffany J Mellott, Olivia M Huleatt, Bethany N Shade, Sarah M Pender, Yi B Liu, Barbara E Slack, Jan K Blusztajn
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170450 (2017)
Prevention of Alzheimer's disease (AD) is a major goal of biomedical sciences. In previous studies we showed that high intake of the essential nutrient, choline, during gestation prevented age-related memory decline in a rat model. In this study we i
Externí odkaz:
https://doaj.org/article/b87ba5620aff442b90fb45e2acfb2181
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94287 (2014)
The development of an effective therapy for Alzheimer's disease (AD) is a major challenge to biomedical sciences. Because much of early AD pathophysiology includes hippocampal abnormalities, a viable treatment strategy might be to use trophic factors
Externí odkaz:
https://doaj.org/article/d0b1f49616ee437895bfdb2fe02d6eae
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e21166 (2011)
Cholinergic projection from the septum to the hippocampus is crucial for normal cognitive function and degeneration of cells and nerve fibers within the septohippocampal pathway contributes to the pathophysiology of Alzheimer's disease. Bone morphoge
Externí odkaz:
https://doaj.org/article/b1d97cca8364409a959065d2660b1586
Autor:
Sarah J.E. Wong-Goodrich, Tiffany J. Mellott, Melissa J. Glenn, Jan K. Blusztajn, Christina L. Williams
Publikováno v:
Neurobiology of Disease, Vol 30, Iss 2, Pp 255-269 (2008)
Prenatal choline supplementation (SUP) protects adult rats against spatial memory deficits observed after excitotoxin-induced status epilepticus (SE). To examine the mechanism underlying this neuroprotection, we determined the effects of SUP on a var
Externí odkaz:
https://doaj.org/article/3e9d41a85c094fe383336c4b78bfa5fb
Autor:
Bruce G. Jenkins, Alpaslan Dedeoglu, Tiffany J. Mellott, Ji-Kyung Choi, Isabel Carreras, Jan Krzysztof Blusztajn, Nurgul Aytan, Kimberly A. Leite-Morris, Leah Crabtree, Margaret Lehar
Publikováno v:
Brain Research. 1681:34-43
Gulf War Illness (GWI) is a chronic disease that affects the 1991 Gulf War (GW) veterans for which treatment is lacking. It has been hypothesized that drugs used to protect military personnel from chemical attacks and insects during the war: pyridost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ce151a0fc01ccfc7111b9739a2b0afa
https://doi.org/10.1016/j.brainres.2017.12.030
https://doi.org/10.1016/j.brainres.2017.12.030
Autor:
Isabel Carreras, Leah Crabtree, Bruce G. Jenkins, Alpaslan Dedeoglu, Nurgul Aytan, Ji-Kyung Choi, Jan Krzysztof Blusztajn, Kimberly A. Leite-Morris, Margaret Lehar, Tiffany J. Mellott
Publikováno v:
Brain research. 1688
Gulf War Illness (GWI) is a chronic disease that affects the 1991 Gulf War (GW) veterans for which treatment is lacking. It has been hypothesized that drugs used to protect military personnel from chemical attacks and insects during the war: pyridost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abc998d0873727f2c7a7550147d25b76
https://pubmed.ncbi.nlm.nih.gov/29277710
https://pubmed.ncbi.nlm.nih.gov/29277710
Autor:
Jan Krzysztof Blusztajn, Sudha Seshadri, Stephanie L. Adams, Ivana Delalle, Tiffany J. Mellott, Laurent Benayoun, Kathy Tilton
The pathophysiology of Alzheimer's disease (AD) includes signaling defects mediated by the transforming growth factor β-bone morphogenetic protein-growth and differentiation factor (TGFβ-BMP-GDF) family of proteins. In animal models of AD, administ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f07ba6f58df7bd08000dce807e31d040
https://europepmc.org/articles/PMC5988976/
https://europepmc.org/articles/PMC5988976/
Publikováno v:
Central Nervous System Agents in Medicinal Chemistry. 12:82-94
Choline is an essential nutrient for humans. Metabolically choline is used for the synthesis of membrane phospholipids (e.g. phosphatidylcholine), as a precursor of the neurotransmitter acetylcholine, and, following oxidation to betaine, choline func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b21b9f539d2a2a5ac5b2da734423f9d9
https://doi.org/10.2174/187152412800792706
https://doi.org/10.2174/187152412800792706