Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Tiffany Hylkema"'
Autor:
Andrew J. Menssen, Chad A. Hudson, Todd Alonzo, Robert Gerbing, Laura Pardo, Amanda Leonti, Jacqueline A. Cook, Fan-Chi Hsu, Loren L. Lott, Fangyan Dai, Collette Fearing, Keely Ghirardelli, Tiffany Hylkema, Katherine Tarlock, Keith R. Loeb, Edward A. Kolb, Todd Cooper, Jessica Pollard, Denise A. Wells, Michael R. Loken, Richard Aplenc, Soheil Meshinchi, Lisa Eidenschink Brodersen
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
As curative therapies for pediatric AML remain elusive, identifying potential new treatment targets is vital. We assessed the cell surface expression of CD74, also known as the MHC-II invariant chain, by multidimensional flow cytometry in 973 patient
Externí odkaz:
https://doaj.org/article/d6be1ca886894ebe8d63c195735d6fd2
Autor:
Hamid Bolouri, Rhonda E. Ries, Alice E. Wiedeman, Tiffany Hylkema, Sheila Scheiding, Vivian H. Gersuk, Kimberly O’Brien, Quynh-Anh Nguyen, Jenny L. Smith, S. Alice Long, Soheil Meshinchi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
IL6 expression in the bone marrow is associated with reduced survival in paediatric AML. Here, the authors used RNA-seq to identify treatment resistance-associated co-occurring inflammatory signalling in leukemic cells.
Externí odkaz:
https://doaj.org/article/135f6f6b486a456e8346955a1b0198e3
Autor:
Hamid Bolouri, Rhonda Ries, Laura Pardo, Tiffany Hylkema, Wanding Zhou, Jenny L. Smith, Amanda Leonti, Michael Loken, Jason E. Farrar, Timothy J. Triche, Soheil Meshinchi
Publikováno v:
PLoS ONE, Vol 16, Iss 11 (2021)
Infant Acute Myeloid Leukemia (AML) is a poorly-addressed, heterogeneous malignancy distinguished by surprisingly few mutations per patient but accompanied by myriad age-specific translocations. These characteristics make treatment of infant AML chal
Externí odkaz:
https://doaj.org/article/d13c5f80eaca472491942928dac038df
Autor:
Jason E. Farrar, Jenny L. Smith, Megan Othus, Benjamin J. Huang, Yi-Cheng Wang, Rhonda Ries, Tiffany Hylkema, Era L. Pogosova-Agadjanyan, Sneha Challa, Amanda Leonti, Timothy I. Shaw, Timothy J. Triche, Alan S. Gamis, Richard Aplenc, E. Anders Kolb, Xiaotu Ma, Derek L. Stirewalt, Todd A. Alonzo, Soheil Meshinchi
Publikováno v:
Journal of Clinical Oncology. 41:2949-2962
PURPOSE Optimized strategies for risk classification are essential to tailor therapy for patients with biologically distinctive disease. Risk classification in pediatric acute myeloid leukemia (pAML) relies on detection of translocations and gene mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76ef473648313347225baef9d1b228a4
https://doi.org/10.1200/jco.22.01114
https://doi.org/10.1200/jco.22.01114
Autor:
Quy Le, Thao Tang, Amanda Leonti, Sommer Castro, Cyd Nourigat McKay, LaKeisha Perkins, Laura Pardo, Danielle Kirkey, Tiffany Hylkema, Lindsey Call, Makia Manselle, Cristina Abrahams, Kristin Bedard, Arturo Molina, Lisa Eidenshinck Brodersen, Michael R. Loken, Katherine Tarlock, Soheil Meshinchi, Keith R. Loeb
Publikováno v:
Blood Advances. 7:1666-1670
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfe9eaad79fc783e4ad266909765d472
https://doi.org/10.1182/bloodadvances.2022008303
https://doi.org/10.1182/bloodadvances.2022008303
Autor:
Jessica A. Pollard, Soheil Meshinchi, Alan S. Gamis, Irwin Bernstein, Richard Aplenc, Lillian Sung, Betsy Hirsch, Susana C. Raimondi, Leela Sarukkai, Jason Joaquin, Tiffany Hylkema, Laura Pardo, Michael R. Loken, Rhonda Ries, Robert B. Gerbing, Yi-Cheng Wang, Todd A. Alonzo, Katherine Tarlock
Supplementary Table 5. Outcome for KIT E8+ mutation positive patients according to treatment arm (No GO vs. GO)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3966b178badc4203ce66d03090b9e5e9
https://doi.org/10.1158/1078-0432.22473624
https://doi.org/10.1158/1078-0432.22473624
Autor:
Soheil Meshinchi, Hamid Bolouri, Vivian G. Oehler, Michael R. Loken, Daoud Meerzaman, Cu Nguyen, Timothy J. Triche, Jason E. Farrar, E. Anders Kolb, Richard Aplenc, Alan S. Gamis, Amanda R. Leonti, Suzan Imren, Quy Le, Keith R. Loeb, Carrie L. Cummings, Laura Pardo, Lisa Eidenschink Brodersen, Marianne T. Santaguida, Robert B. Gerbing, Todd A. Alonzo, Tiffany Hylkema, Rhonda E. Ries, Jenny L. Smith
Supplemental methods that provides additional detail on statistical methods and laboratory protocols and reagents.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4d053ad8381ae01e162498ef0390540
https://doi.org/10.1158/1078-0432.22473326.v1
https://doi.org/10.1158/1078-0432.22473326.v1
Autor:
Jessica A. Pollard, Soheil Meshinchi, Alan S. Gamis, Irwin Bernstein, Richard Aplenc, Lillian Sung, Betsy Hirsch, Susana C. Raimondi, Leela Sarukkai, Jason Joaquin, Tiffany Hylkema, Laura Pardo, Michael R. Loken, Rhonda Ries, Robert B. Gerbing, Yi-Cheng Wang, Todd A. Alonzo, Katherine Tarlock
Purpose:KIT mutations (KIT+) are common in core binding factor (CBF) AML and have been associated with varying prognostic significance. We sought to define the functional and clinical significance of distinct KIT mutations in CBF pediatric AML.Experi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9860ab06204f027f3d41754b27b9e08e
https://doi.org/10.1158/1078-0432.c.6528567
https://doi.org/10.1158/1078-0432.c.6528567
Autor:
Jessica A. Pollard, Soheil Meshinchi, Alan S. Gamis, Irwin Bernstein, Richard Aplenc, Lillian Sung, Betsy Hirsch, Susana C. Raimondi, Leela Sarukkai, Jason Joaquin, Tiffany Hylkema, Laura Pardo, Michael R. Loken, Rhonda Ries, Robert B. Gerbing, Yi-Cheng Wang, Todd A. Alonzo, Katherine Tarlock
Supplemental Figure 2. Functional Evaluation and TKI response of E11 mutations. (A) Evaluation of the phosphorylation status of KIT following transfection of the mutations in exon 11, V559D and L576P, into HEK293 cell line. (B) IL-3 independent growt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82b46e0a5b8e40db5a951794f95fcdfc
https://doi.org/10.1158/1078-0432.22473642.v1
https://doi.org/10.1158/1078-0432.22473642.v1
Autor:
Soheil Meshinchi, Hamid Bolouri, Vivian G. Oehler, Michael R. Loken, Daoud Meerzaman, Cu Nguyen, Timothy J. Triche, Jason E. Farrar, E. Anders Kolb, Richard Aplenc, Alan S. Gamis, Amanda R. Leonti, Suzan Imren, Quy Le, Keith R. Loeb, Carrie L. Cummings, Laura Pardo, Lisa Eidenschink Brodersen, Marianne T. Santaguida, Robert B. Gerbing, Todd A. Alonzo, Tiffany Hylkema, Rhonda E. Ries, Jenny L. Smith
Supplemental tables including clinical characteristics and differentially expressed gene lists.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be32a0668256386af1fd09fc0ba896c6
https://doi.org/10.1158/1078-0432.22473323
https://doi.org/10.1158/1078-0432.22473323