Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Tiffany G. Chan"'
Autor:
William Lim Kee Chang, Tiffany G. Chan, Federica Raguseo, Aishwarya Mishra, Dani Chattenton, Rafael T. M. de Rosales, Nicholas J. Long, Sophie V. Morse
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Focused ultrasound and microbubbles can non-invasively and locally deliver therapeutics and imaging agents across the blood–brain barrier. Uniform treatment and minimal adverse bioeffects are critical to achieve reliable doses and enable s
Externí odkaz:
https://doaj.org/article/11a30846bd024c9fbf584d07a4e35e5d
Autor:
Helena R. Watts, Michelle Simon, Viktoria Rakers, Francesco A. Aprile, Carmen L. Ruehl, Tiffany G. Chan, Ramon Vilar, James J. Choi, Sophie V. Morse
Publikováno v:
Chemical Science
One of the key hallmarks of Alzheimer's disease is the aggregation of the amyloid-β peptide to form fibrils. Consequently, there has been great interest in studying molecules that can disrupt amyloid-β aggregation. While a handful of molecules have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9172a799fa8336e9d65d66d954a03de4
http://europepmc.org/articles/PMC8278877
http://europepmc.org/articles/PMC8278877
Autor:
Tiffany G. Chan, Felicity N. E. Gavins, James J. Choi, Nicholas J. Long, Sophie V. Morse, Tamara Boltersdorf
Publikováno v:
RSC Chemical Biology. 1:385-389
To image activated microglia, a small-molecule FPR2/ALX-targeted fluorescent probe was locally delivered into the brain using focused ultrasound and microbubbles. The probe did not co-localise with neurons or astrocytes but accumulated in activated m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a61adf5e0c0a8a4dd8903824e47fc86d
https://doi.org/10.1039/d0cb00140f
https://doi.org/10.1039/d0cb00140f
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 341
Liposomes are clinically used drug carriers designed to improve the delivery of drugs to specific tissues while minimising systemic distribution. However, liposomes are unable to cross the blood-brain barrier (BBB) and enter the brain, mostly due to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dfd65200934efdc3bab9f26ea9bb122
https://pubmed.ncbi.nlm.nih.gov/34896448
https://pubmed.ncbi.nlm.nih.gov/34896448
Publikováno v:
Journal of Nuclear Medicine
In recent years, targeted radionuclide therapy (TRT) has emerged as a promising strategy for cancer treatment. In contrast to conventional radiotherapy, TRT delivers ionizing radiation to tumors in a targeted manner, reducing the dose that healthy ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f69e42c4c0dd1c2fffbf541c99c79306
https://ora.ox.ac.uk/objects/uuid:1476bc02-ebc0-4a6c-a253-caa7e9ecb501
https://ora.ox.ac.uk/objects/uuid:1476bc02-ebc0-4a6c-a253-caa7e9ecb501
Metal-based anion receptors have several important applications in sensing, separation and transport of negatively charged species. Amongst these receptors, di-zinc(ii) complexes are of particular interest for the recognition of oxoanions, in particu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85b7f0193dd6ee4e1537d462a43a6512
http://hdl.handle.net/10044/1/78158
http://hdl.handle.net/10044/1/78158
Autor:
Nicoleta Baxan, Hee Seok Jung, Antonios N. Pouliopoulos, Bethany I. Harriss, James J. Choi, Nicholas J. Long, Sophie V. Morse, Tamara Boltersdorf, Tiffany G. Chan
Publikováno v:
Theranostics
Gadolinium-based magnetic resonance imaging contrast agents can provide information regarding neuronal function, provided that these agents can cross the neuronal cell membrane. Such contrast agents are normally restricted to extracellular domains, h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94f71f6f8eafcec7b5edf66fcbe7ef0b
http://hdl.handle.net/10044/1/76841
http://hdl.handle.net/10044/1/76841
Autor:
Sophie V. Morse, Nicholas J. Long, Antonios N. Pouliopoulos, Tiffany G. Chan, Matthew J. Copping, Julien Lin, James J. Choi
Publikováno v:
Radiology
BACKGROUND: Previous work has demonstrated that drugs can be delivered across the blood-brain barrier by exposing circulating microbubbles to a sequence of long ultrasound pulses. Although this sequence has successfully delivered drugs to the brain,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3bd21632967b6141e92c2449927114e
https://europepmc.org/articles/PMC6493324/
https://europepmc.org/articles/PMC6493324/