Výsledky vyhledávání - "Tiffany A. Zamzow"

Cytidine deaminase genotype and toxicity of cytosine arabinoside therapy in children with acute myeloid leukemia

Autor: Stella M. Davies, Soheil Meshinchi, Heather D. Conner, Robert B. Gerbing, Hartmut Geiger, John P. Perentesis, Tiffany A. Zamzow, Julie A. Ross, Todd A. Alonzo, Parinda A. Mehta, Deepika Bhatla, Xiaowen Zhai

Publikováno v: British Journal of Haematology. 144:388-394

Cytosine arabinoside (ara-C) is irreversibly deaminated to a non-toxic metabolite by cytidine deaminase (CDA). A common polymorphism, A79C, in the gene encoding cytidine deaminase (CDA) changes a lysine residue to glutamine resulting in decreased enz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21e0a0addc726c3dee1df62052dc2cb0
https://doi.org/10.1111/j.1365-2141.2008.07461.x

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FAS Promoter Polymorphism: Outcome of Childhood Acute Myeloid Leukemia. A Children's Oncology Group Report

Autor: John P. Perentesis, Michelle D. Combs, Beverly J. Lange, Julie A. Ross, Emily Stover, Todd A. Alonzo, Tiffany A. Zamzow, Stella M. Davies, James Elliott, Soheil Meschinchi, Robert B. Gerbing, Parinda A. Mehta

Publikováno v: Clinical Cancer Research. 14:7896-7899

Purpose: FAS is a cell surface receptor involved in apoptotic signal transmission. Deregulation of this pathway results in down-regulation of apoptosis and subsequent persistence of a malignant clone. A single nucleotide polymorphism resulting in gua

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f544919cb2e8db0476a50042d7ebeb8d
https://doi.org/10.1158/1078-0432.ccr-08-0418

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Perforin polymorphism A91V and susceptibility to B-precursor childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group

Autor: Jeanette Pullen, S.M. Davies, Susan Molleran Lee, Joyce Villanueva, Ashok Kumar, Alexandra H. Filipovich, Tiffany A. Zamzow, Parinda A. Mehta, Meenakshi Devidas, James Elliott, Y Zewge

Publikováno v: Leukemia. 20:1539-1541

Perforin plays a key role in the cytotoxicity of natural killer and cytotoxic T cells. Genetic mutations in the perforin gene (PRF1) give rise to approximately 30% cases of familial hemophagocytic lymphohistiocytosis. A frequent polymorphism, A91V (C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::887f55a601deed6f78204ed462976a17
https://doi.org/10.1038/sj.leu.2404299

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