Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Tiffany A. Hylkema"'
Autor:
Quy Le, Brandon Hadland, Jenny L. Smith, Amanda Leonti, Benjamin J. Huang, Rhonda Ries, Tiffany A. Hylkema, Sommer Castro, Thao T. Tang, Cyd N. McKay, LaKeisha Perkins, Laura Pardo, Jay Sarthy, Amy K. Beckman, Robin Williams, Rhonda Idemmili, Scott Furlan, Takashi Ishida, Lindsey Call, Shivani Srivastava, Anisha M. Loeb, Filippo Milano, Suzan Imren, Shelli M. Morris, Fiona Pakiam, Jim M. Olson, Michael R. Loken, Lisa Brodersen, Stanley R. Riddell, Katherine Tarlock, Irwin D. Bernstein, Keith R. Loeb, Soheil Meshinchi
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 22 (2022)
The CBFA2T3-GLIS2 (C/G) fusion is a product of a cryptic translocation primarily seen in infants and early childhood and is associated with dismal outcome. Here, we demonstrate that the expression of the C/G oncogenic fusion protein promotes the tran
Externí odkaz:
https://doaj.org/article/134ccd270d5242848fcfcd4f706249e4
Autor:
Laura Pardo, Alan S. Gamis, Michael R. Loken, Lisa Eidenschink Brodersen, E. Anders Kolb, William G. Woods, Jenny L. Smith, Todd Cooper, Tiffany A. Hylkema, Todd A. Alonzo, Richard Aplenc, Rhonda E. Ries, Katherine Tarlock, Yi-Cheng Wang, Amanda R. Leonti, Robert B. Gerbing, Soheil Meshinchi, Adam J. Lamble
Publikováno v:
Blood
Biallelic CEBPA mutations are associated with favorable outcomes in acute myeloid leukemia (AML). We evaluated the clinical and biologic implications of CEBPA-basic leucine zipper (CEBPA-bZip) mutations in children and young adults with newly diagnos
Therapeutic Targeting of Mesothelin with Chimeric Antigen Receptor T Cells in Acute Myeloid Leukemia
Autor:
Katherine Tarlock, Salvatore Fiorenza, Soheil Meshinchi, Lindsey F Call, Quy Le, Cameron J. Turtle, Anisha M Loeb, Cyd Nourigat McKay, Jenny L. Smith, Michael R. Loken, Shivani Srivastava, LaKeisha Perkins, Rhonda E. Ries, Stanley R. Riddell, Amanda R. Leonti, Colin Correnti, Laura Pardo, Thao T. Tang, Tiffany A. Hylkema, Sommer Castro
Publikováno v:
Clinical Cancer Research. 27:5718-5730
Purpose: We previously identified mesothelin (MSLN) as highly expressed in a significant fraction of acute myeloid leukemia (AML) but entirely silent in normal hematopoiesis, providing a promising antigen for immunotherapeutic targeting that avoids h
Autor:
Danielle C. Kirkey, Xiaoying Wu, Rhonda E. Ries, Tiffany A. Hylkema, Yanling Liu, Pandurang Kolekar, Quang Tran, Alan S. Gamis, Richard Aplenc, Anders E. Kolb, Todd A. Alonzo, Katherine Tarlock, Robert Eisenman, Soheil Meshinchi
Publikováno v:
Blood. 140:3395-3396
Autor:
Jason E Farrar, Jenny L. Smith, Megan Othus, Benjamin J. Huang, Yi-Cheng Wang, Rhonda E. Ries, Tiffany A. Hylkema, Era L Pogosova-Agadjanyan, Sneha Challa, Amanda R. Leonti, Timothy I. Shaw, Timothy Junius Triche, Alan S. Gamis, Richard Aplenc, Anders E. Kolb, Xiaotu Ma, Derek Stirewalt, Todd A. Alonzo, Soheil Meshinchi
Publikováno v:
Blood. 140:9173-9174
Autor:
Tiffany A. Hylkema, Julia E. Maxson, Rhonda E. Ries, Robert B. Gerbing, Soheil Meshinchi, Todd A. Alonzo, Jenny L. Smith, Katherine Tarlock, Yi-Cheng Wang
Publikováno v:
Blood
Truncation mutations in the granulocyte colony-stimulating factor receptor gene (CSF3R) are a rare abnormality in pediatric acute myeloid leukemia, and are usually associated either with mutations in CEBPA or with t(8;21). Through sequencing of over
Autor:
Keith R. Loeb, Richard Aplenc, Robert B. Gerbing, E. Anders Kolb, Amanda R. Leonti, Hamid Bolouri, Laura Pardo, Alan S. Gamis, Rhonda E. Ries, Todd A. Alonzo, Jenny L. Smith, Soheil Meshinchi, Suzan Imren, Lisa Eidenschink Brodersen, Vivian G. Oehler, Timothy J. Triche, Cu Nguyen, Jason E. Farrar, Carrie L. Cummings, Michael R. Loken, Daoud Meerzaman, Tiffany A. Hylkema, Quy Le, Marianne Santaguida
Publikováno v:
Clinical Cancer Research. 26:726-737
Purpose: A cryptic inv(16)(p13.3q24.3) encoding the CBFA2T3–GLIS2 fusion is associated with poor outcome in infants with acute megakaryocytic leukemia. We aimed to broaden our understanding of the pathogenesis of this fusion through transcriptome p
Autor:
Jay F. Sarthy, Suzan Imren, Brandon Hadland, Soheil Meshinchi, Sommer Castro, Keith R. Loeb, Benjamin J. Huang, Cynthia Nourigat, Scott N. Furlan, LaKeisha Perkins, Shivani Srivastava, Rhonda E. Ries, Thao T Tang, Irwin D. Bernstein, Jenny L. Smith, Lisa Eidenschink Brodersen, Katherine Tarlock, Stanley R. Riddell, Larua Pardo, Lindsey F Call, Amy Beckman, Rhonda Idemmili, Amanda R. Leonti, Tiffany A. Hylkema, Takashi Ishida, Anisha M Loeb, Quy Le, Loken Michael, Robin Williams
Fusion oncoproteins are the initiating event in AML pathogenesis, although they are thought to require additional cooperating mutations for leukemic transformation. CBFA2T3-GLIS2 (C/G) fusion occurs exclusively in infants and is associated with highl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::006f550daf8c2558a104753f1a38f789
https://doi.org/10.21203/rs.3.rs-757279/v1
https://doi.org/10.21203/rs.3.rs-757279/v1
Autor:
Tiffany A. Hylkema, Irwin D. Bernstein, Jessica A. Pollard, Michael R. Loken, Todd A. Alonzo, Laura Pardo, Alan S. Gamis, Richard Aplenc, Soheil Meshinchi, Lillian Sung, Robert B. Gerbing, Susana C. Raimondi, Betsy A. Hirsch, Rhonda E. Ries, Leela Sarukkai, Katherine Tarlock, Yi-Cheng Wang, Jason Joaquin
Publikováno v:
Clinical Cancer Research. 25:5038-5048
Purpose: KIT mutations (KIT+) are common in core binding factor (CBF) AML and have been associated with varying prognostic significance. We sought to define the functional and clinical significance of distinct KIT mutations in CBF pediatric AML. Expe
Autor:
Leila Robinson, Amanda Leonti, Todd A. Alonzo, Yi-Cheng Wang, Michele S. Redell, Rhonda E. Ries, Jenny L. Smith, Tiffany A. Hylkema, Quy Le, E Anders Kolb, Richard Aplenc, Xiaotu Ma, Jeffrey Klco, Katherine Tarlock, Soheil Meshinchi
Publikováno v:
Cancer Research. 82:3479-3479
Childhood AML is an aggressive disease with high rates of failures and poor survival. We have demonstrated that the molecular landscape of AML in children is distinct, and co-occurrence of variants modulate outcomes. Recent discovery of tandem duplic