Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Tiffaney Vincent"'
Autor:
Jon C. Aster, Noori Sotudeh, Jens G. Lohr, David T. Teachey, Guangwu Guo, Monica S. Nair, Tushara Vijaykumar, Praveen Anand, Huiyoung Yun, Anna Jollyette Rogers, Daniel J. DeAngelo, Yotam Drier, Andrew E. Place, Sayalee Potdar, Julia Frede, Tiffaney Vincent, Andrew A. Lane, Madhu M. Ouseph, Amy Guillaumet-Adkins, Jake A. Kloeber, Randi Isenhart, Lewis B. Silverman, Bradley E. Bernstein, Leili Niu, Marian H. Harris, Birgit Knoechel, Valeriya Dimitrova
Publikováno v:
Blood
Lineage plasticity and stemness have been invoked as causes of therapy resistance in cancer, because these flexible states allow cancer cells to dedifferentiate and alter their dependencies. We investigated such resistance mechanisms in relapsed/refr
Autor:
Caroline Diorio, Ryan Murray, Mark Naniong, Luis Barrera, Adam Camblin, John Chukinas, Lindsey Coholan, Aaron Edwards, Tori Fuller, Claudia Gonzales, Stephan A. Grupp, Alden Ladd, Melissa Le, Angelica Messana, Faith Musenge, Haley Newman, Yeh-Chuin Poh, Henry Poulin, Theresa Ryan, Rawan Shraim, Sarah K. Tasian, Tiffaney Vincent, Lauren Young, Yingying Zhang, Giuseppe Ciaramella, Jason Gehrke, David T. Teachey
Publikováno v:
Blood. 140(6)
Allogeneic chimeric antigen receptor T-cell (CART) therapies require multiple gene edits to be clinically tractable. Most allogeneic CARTs have been created using gene editing techniques that induce DNA double-stranded breaks (DSBs), resulting in uni
Autor:
Carolyn A. Felix, Patrizia Porazzi, Joanne M. Hilden, James W Davenport, Sarah K. Tasian, Meenakshi Devidas, ZoAnn E. Dreyer, Shenghao Jin, I-Ming L. Chen, Alix E. Seif, Tiffaney Vincent, Andrew J. Carroll, Martin Carroll, Blaine W. Robinson, Karen A. Urtishak, David T. Teachey, Katherine L. B. Borden, Biljana Culjkovic-Kraljacic, Stephen P. Hunger, Li-San Wang, Jeffrey S. Barrett, Jonni S. Moore, Richard C. Harvey, Nyla A. Heerema, Cheryl L. Willman
Publikováno v:
Oncogene
The poor outcomes in infant acute lymphoblastic leukemia (ALL) necessitate new treatments. Here we discover that EIF4E protein is elevated in most cases of infant ALL and test EIF4E targeting by the repurposed antiviral agent ribavirin, which has ant
Autor:
Anica M. Wandler, Benjamin J. Huang, Tiffaney Vincent, Michelle L. Hermiston, Aaron Hechmer, Brent L. Wood, Kevin Shannon, Lauren K. Meyer, Cristina Delgado-Martin, Terzah M. Horton, Adam B. Olshen, David T. Teachey, Paolo Fortina, Ritu Roy
Publikováno v:
J Clin Invest
The Journal of clinical investigation, vol 130, iss 2
The Journal of clinical investigation, vol 130, iss 2
Glucocorticoids (GCs) are a central component of therapy for patients with T cell acute lymphoblastic leukemia (T-ALL), and although resistance to GCs is a strong negative prognostic indicator in T-ALL, the mechanisms of GC resistance remain poorly u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07d78e24c2adb2d118232ebc5babcafc
https://europepmc.org/articles/PMC6994137/
https://europepmc.org/articles/PMC6994137/
Autor:
William L. Carroll, Jacob Nersting, Teena Bhatla, Jason Saliba, David T. Teachey, Tiffaney Vincent, Jun J. Yang, Julia Meyer, Stephen P. Hunger, Nikki A. Evensen, David J. Araten, Ashfiyah Chowdhury, Kjeld Schmiegelow, P. Pallavi Madhusoodhan
Publikováno v:
Haematologica
Evensen, N A, Madhusoodhan, P P, Meyer, J, Saliba, J, Chowdhury, A, Araten, D J, Nersting, J, Bhatla, T, Vincent, T L, Teachey, D, Hunger, S P, Yang, J, Schmiegelow, K & Carroll, W L 2018, ' MSH6 haploinsufficiency at relapse contributes to the development of thiopurine resistance in pediatric B-lymphoblastic leukemia ', Haematologica, vol. 103, no. 5, pp. 830-839 . https://doi.org/10.3324/haematol.2017.176362
Evensen, N A, Madhusoodhan, P P, Meyer, J, Saliba, J, Chowdhury, A, Araten, D J, Nersting, J, Bhatla, T, Vincent, T L, Teachey, D, Hunger, S P, Yang, J, Schmiegelow, K & Carroll, W L 2018, ' MSH6 haploinsufficiency at relapse contributes to the development of thiopurine resistance in pediatric B-lymphoblastic leukemia ', Haematologica, vol. 103, no. 5, pp. 830-839 . https://doi.org/10.3324/haematol.2017.176362
Survival of children with relapsed acute lymphoblastic leukemia is poor, and understanding mechanisms underlying resistance is essential to developing new therapy. Relapse-specific heterozygous deletions in MSH6, a crucial part of DNA mismatch repair
Autor:
Tiffaney Vincent, Rawan Shraim, Changya Chen, Yusha Sun, Anusha Thadi, Sydney D'Amaddio, Kai Tan, Chia-hui Chen, David T. Teachey, Jason Xu, Elizabeth Li, Jackie Peng
Publikováno v:
Blood. 138:618-618
Early T-Cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) is a treatment resistant type of pediatric leukemia whose biology is poorly understood, and new therapies are badly needed. While there are ongoing efforts to profile ETP-ALL using bulk an
Autor:
Terzah M. Horton, Lauren K. Meyer, Mignon L. Loh, Kimberly P. Dunsmore, Benjamin J. Huang, Meenakshi Devidas, Michelle L. Hermiston, Yu Liu, David T. Teachey, Adam B. Olshen, Stephen P. Hunger, Cristina Delgado-Martin, Tiffaney Vincent, Brent L. Wood, Jinghui Zhang, Ritu Roy, Charles G. Mullighan, Robert J. Hayashi, Stuart S. Winter, Elizabeth A. Raetz
Publikováno v:
Journal of Clinical Oncology. 39:10002-10002
10002 Background: The heterogeneity of T-ALL has hindered biomarker identification and limited biology-based risk stratification. Historically, minimal residual disease (MRD) has been the strongest predictor of poor outcomes. However, stratification
Autor:
Feng Shen, Richard C. Harvey, Sarah K. Tasian, Tiffaney Vincent, Cheryl L. Willman, I-Ming Chen, Mignon L. Loh, Theresa Ryan, Alexander E. Perl, Yong Li, David T. Teachey, Stephan A. Grupp, Stephen P. Hunger, Martin Carroll
Publikováno v:
Blood. 129:177-187
Philadelphia chromosome (Ph)-like B-cell acute lymphoblastic leukemia (Ph-like ALL) is associated with activated JAK/STAT, Abelson kinase (ABL), and/or phosphatidylinositol 3-kinase (PI3K) signaling and poor clinical outcomes. PI3K pathway signaling
Autor:
Edward E. Morrisey, Su Zhou, Jarod A. Zepp, David B. Frank, Tien Peng, Tiffaney Vincent, Ian J. Penkala, Min Min Lu, Zheng Cui, Melinda Snitow, Michael J. Herriges, Michael Morley
Publikováno v:
Cell reports, vol 17, iss 9
Alveologenesis is the culmination of lung development and involves the correct temporal and spatial signals to generate the delicate gas exchange interface required for respiration. Using a Wnt-signaling reporter system, we demonstrate the emergence
Autor:
Brent L. Wood, Theresa Ryan, Richard B. Lock, David T. Teachey, Stephan A. Grupp, Sibasish Dolai, Mignon L. Loh, Junior Hall, Arthavan Selvanathan, Sarah K. Tasian, Alissa Robbins, Cristina Delgado-Martin, Stephen P. Hunger, Charles G. Mullighan, Shannon L. Maude, Andrew C. Wood, Michelle L. Hermiston, Tiffaney Vincent
Publikováno v:
Blood. 125:1759-1767
Early T-cell precursor (ETP) acute lymphoblastic leukemia (ALL) is a recently described subtype of T-ALL characterized by a unique immunophenotype and genomic profile, as well as a high rate of induction failure. Frequent mutations in cytokine recept