Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Tifanie Sbriscia"'
Autor:
Sheela Bhattacharjee, Allan George, Scott G. Lundeen, Olivia Linton, Pamela Tannenbaum, Xuqing Zhang, Donna Haynes-Johnson, Tifanie Sbriscia, Zhihua Sui, Muh-Tsann Lai
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 134:51-58
Selective androgen receptor modulators (SARMs) are androgens with tissue-selective activity. SARMs that have anabolic activity on muscle while having minimal stimulatory activity on prostate are classified as SARM agonists. They can be used to preven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::274894ce92f19f7cce1d2ec5e29622ad
https://doi.org/10.1016/j.jsbmb.2012.10.015
https://doi.org/10.1016/j.jsbmb.2012.10.015
Autor:
Zhihua Sui, Raymond A. Ng, Muh-Tsann Lai, Olivia Linton, Scott G. Lundeen, Sheela Bhattacharjee, George F. Allan, Tifanie Sbriscia, Donna Haynes-Johnson
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 110:207-213
Androgens are required for the maintenance of normal sexual activity in adulthood and for enhancing muscle growth and lean body mass in adolescents and adults. Androgen receptor (AR) ligands with tissue selectivity (selective androgen receptor modula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d3967956d5c7bb78cbe93df34d78c81
https://doi.org/10.1016/j.jsbmb.2007.10.012
https://doi.org/10.1016/j.jsbmb.2007.10.012
Autor:
Olivia Linton, Tifanie Sbriscia, Xuqing Zhang, George F. Allan, Muh-Tsann Lai, Sheela Bhattacharjee, Zhihua Sui, Donna Haynes-Johnson, Scott G. Lundeen, Pamela Tannenbaum
Publikováno v:
Endocrine. 32:41-51
Androgen receptor (AR) ligands with tissue selectivity (selective androgen receptor modulators, or SARMs) have potential for treating muscle wasting, hypogonadism of aging, osteoporosis, female sexual dysfunction, and other indications. JNJ-28330835
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fda1f9701470ab79fa74d84ce290bc93
https://doi.org/10.1007/s12020-007-9005-2
https://doi.org/10.1007/s12020-007-9005-2
Autor:
Scott G. Lundeen, George F. Allan, Olivia Linton, Xuqing Zhang, Xiaojie Li, Tifanie Sbriscia, Zhihua Sui
Publikováno v:
Journal of Medicinal Chemistry. 50:3857-3869
A novel series of pyrazolines 2 have been designed, synthesized, and evaluated by in vivo screening as tissue-selective androgen receptor modulators (SARMs). Structure-activity relationships (SAR) were investigated at the R1 to R6 positions as well a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70d916080010ae6e87d96c366b9b2ebd
https://doi.org/10.1021/jm0613976
https://doi.org/10.1021/jm0613976
Autor:
James C. Lanter, Vernon C. Alford, Tifanie Sbriscia, George F. Allan, Zhihua Sui, Ng Raymond A, Scott G. Lundeen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:1784-1787
The synthesis and in vivo SAR of 2-(2,2,2)-trifluoroethyl-benzimidazoles are described. Prostate antagonism and/or levator ani agonism can be modulated by varying the substitution at the 2-position of 5,6-dichloro-benzimidazoles. Potent androgen agon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c9c94334b50df256ba1840e97fd40f0
https://doi.org/10.1016/j.bmcl.2006.12.045
https://doi.org/10.1016/j.bmcl.2006.12.045
Autor:
Zhihua Sui, George F. Allan, James C. Lanter, Olivia Linton, Raymond A. Ng, Tifanie Sbriscia, Scott G. Lundeen, Vernon C. Alford, Jihua Guan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:784-788
The synthesis and in vivo SAR of 5,6-dichloro-benzimidazole derivatives as novel selective androgen receptor antagonists are described. During screening of 2-alkyl benzimidazoles, it was found that a trifluoromethyl group greatly enhances antagonist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c946c8236b59026fcce73b3babce7dbe
https://doi.org/10.1016/j.bmcl.2006.10.071
https://doi.org/10.1016/j.bmcl.2006.10.071
Autor:
Scott G. Lundeen, Jihua Guan, George F. Allan, Raymond A. Ng, James C. Lanter, Tifanie Sbriscia, Zhihua Sui, Vernon C. Alford
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(4)
The synthesis and in vivo SAR of N -benzyl, N -aceto, and N -ethylene ether derivatives of 2-(2,2,2-trifluoroethyl)-5,6-dichloro-benzimidazole as novel androgen receptor antagonists are described. SAR studies led to the discovery of 4-bromo-benzyl be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22f4606ac84076193e9b5cc0917f3ba7
https://pubmed.ncbi.nlm.nih.gov/17134895
https://pubmed.ncbi.nlm.nih.gov/17134895
Autor:
Xuqing Zhang, Zhihua Sui, George F. Allan, Olivia Linton, Xiaojie Li, Scott G. Lundeen, Tifanie Sbriscia
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(2)
A novel imidazolopyrazole derivative has been fortuitously discovered as potent selective androgen receptor modulator with in vivo efficacy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::766974360a4839f532922be2436d074d
https://pubmed.ncbi.nlm.nih.gov/17079140
https://pubmed.ncbi.nlm.nih.gov/17079140
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(22)
A novel series of hydantoin derivatives were identified by in vivo studies as tissue selective androgen receptor modulators. SAR around this series revealed that the function of the ligand could be altered by minor structural modification.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24d9874b24702caf2f182087f68db3f7
https://pubmed.ncbi.nlm.nih.gov/16959487
https://pubmed.ncbi.nlm.nih.gov/16959487
Autor:
Sheela Bhattacharjee, Donna Haynes-Johnson, Zhihua Sui, Scott G. Lundeen, Olivia Linton, Muh-Tsann Lai, Tifanie Sbriscia, George F. Allan, James C. Lanter, Robert Dodds, James J. Fiordeliso
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 103(1)
The pharmacological activity of JNJ-26146900 is described. JNJ-26146900 is a nonsteroidal androgen receptor (AR) ligand with tissue-selective activity in rats. The compound was evaluated in in vitro and in vivo models of AR activity. It binds to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1ea4377350b5951be26baf9a4de0426
https://pubmed.ncbi.nlm.nih.gov/17049844
https://pubmed.ncbi.nlm.nih.gov/17049844