Genome-wide Interaction Analysis of Air Pollution Exposure and Childhood Asthma with Functional Follow-up

Autor: Gref, Anna, Kebede Merid, Simon, Gruzieva, Olena, Ballereau, Stéphane, Becker, Allan, Bellander, Tom, Bergström, Anna, Bossé, Yohan, Bottai, Matteo, Chan-Yeung, Moira, Fuertes, Elaine, Ierodiakonou, Despo, Jiang, Ruiwei, Joly, Stéphane, Jones, Meaghan, Kobor, Michael S, Korek, Michal, Kozyrskyj, Anita L, Kumar, Ashish, Lemonnier, Nathanaël, MacIntyre, Elaina, Ménard, Camille, Nickle, David, Obeidat, Ma'en, Pellet, Johann, Standl, Marie, Sääf, Annika, Söderhäll, Cilla, Tiesler, Carla Mt, van den Berge, Maarten, Vonk, Judith M, Vora, Hita, Xu, Cheng-Jian, Antó, Josep M, Auffray, Charles, Brauer, Michael, Bousquet, Jean, Brunekreef, Bert, Gauderman, W James, Heinrich, Joachim, Kere, Juha, Koppelman, Gerard H, Postma, Dirkje, Carlsten, Christopher, Pershagen, Göran, Melén, Erik, dIRAS RA-2, Risk Assessment, LS IRAS EEPI ME (Milieu epidemiologie), Dep IRAS

Publikováno v: Am. J. Respir. Crit. Care Med. 195, 1373-1383 (2017)
Karolinska Institutet
American Journal of Respiratory and Critical Care Medicine, 195(10), 1373-1383. AMER THORACIC SOC
American Journal of Respiratory and Critical Care Medicine, 195(10), 1373. American Thoracic Society

Rationale: The evidence supporting an association between traffic related air pollution exposure and incident childhood asthma is inconsistent and may depend on genetic factors.Objectives: To identify gene-environment interaction effects on childhood

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ed8d941a7c41a822015046755e6bb1b
https://dspace.library.uu.nl/handle/1874/359697

GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI

Autor: Couto Alves, Alexessander, De Silva, N Maneka G, Karhunen, Ville, Sovio, Ulla, Das, Shikta, Taal, H Rob, Warrington, Nicole M, Lewin, Alexandra M, Kaakinen, Marika, Cousminer, Diana L, Thiering, Elisabeth, Timpson, Nicholas J, Bond, Tom A, Lowry, Estelle, Brown, Christopher D, Estivill, Xavier, Lindi, Virpi, Bradfield, Jonathan P, Geller, Frank, Speed, Doug, Coin, Lachlan JM, Loh, Marie, Barton, Sheila J, Beilin, Lawrence J, Bisgaard, Hans, Bønnelykke, Klaus, Alili, Rohia, Hatoum, Ida J, Schramm, Katharina, Cartwright, Rufus, Charles, Marie-Aline, Salerno, Vincenzo, Clément, Karine, Claringbould, Annique AJ, Van Duijn, Cornelia M, Moltchanova, Elena, Eriksson, Johan G, Elks, Cathy, Feenstra, Bjarke, Flexeder, Claudia, Franks, Stephen, Frayling, Timothy M, Freathy, Rachel M, Elliott, Paul, Widén, Elisabeth, Hakonarson, Hakon, Hattersley, Andrew T, Rodriguez, Alina, Banterle, Marco, Heinrich, Joachim, Heude, Barbara, Holloway, John W, Hofman, Albert, Hyppönen, Elina, Inskip, Hazel, Kaplan, Lee M, Hedman, Asa K, Läärä, Esa, Prokisch, Holger, Grallert, Harald, Lakka, Timo A, Lawlor, Debbie A, Melbye, Mads, Ahluwalia, Tarunveer S, Marinelli, Marcella, Millwood, Iona Y, Palmer, Lyle J, Pennell, Craig E, Perry, John R, Ring, Susan M, Savolainen, Markku J, Rivadeneira, Fernando, Standl, Marie, Sunyer, Jordi, Tiesler, Carla MT, Uitterlinden, Andre G, Schierding, William, O’Sullivan, Justin M, Prokopenko, Inga, Herzig, Karl-Heinz, Smith, George Davey, O'Reilly, Paul, Felix, Janine F, Buxton, Jessica L, Blakemore, Alexandra IF, Ong, Ken K, Jaddoe, Vincent WV, Grant, Struan FA, Sebert, Sylvain, McCarthy, Mark I, Järvelin, Marjo-Riitta

Early childhood growth patterns are associated with adult health, yet the genetic factors and the developmental stages involved are not fully understood. Here, we combine genome-wide association studies with modeling of longitudinal growth traits to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3eb42742bd3a37e246d9a5c88cdf39f5

Genome-wide associations for birth weight and correlations with adult disease.

Autor: Horikoshi M; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Beaumont RN; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, UK., Day FR; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Warrington NM; The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia.; School of Women's and Infants' Health, The University of Western Australia, Perth, Australia., Kooijman MN; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, the Netherlands.; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands.; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, the Netherlands., Fernandez-Tajes J; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Feenstra B; Department of Epidemiology Research, Statens Serum Institute, Copenhagen, Denmark., van Zuydam NR; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Gaulton KJ; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; Department of Pediatrics, University of California San Diego, La Jolla, California, USA., Grarup N; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Bradfield JP; Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Strachan DP; Population Health Research Institute, St George's University of London, London, Cranmer Terrace, UK., Li-Gao R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Ahluwalia TS; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.; Steno Diabetes Center, Gentofte, Denmark., Kreiner E; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., Rueedi R; Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, Finland., Cousminer DL; Institute for Molecular Medicine, Finland (FIMM), University of Helsinki, Helsinki, Finland.; Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Wu Y; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Thiering E; Institute of Epidemiology I, Helmholtz Zentrum München- German Research Center for Environmental Health, Neuherberg, Germany.; Division of Metabolic and Nutritional Medicine, Dr. von Hauner Children's Hospital, University of Munich Medical Center, Munich, Germany., Wang CA; School of Women's and Infants' Health, The University of Western Australia, Perth, Australia., Have CT; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Hottenga JJ; Netherlands Twin Register, Department of Biological Psychology, VU University, Amsterdam, the Netherlands., Vilor-Tejedor N; ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; CIBER de Epidemiología y Salud Pública (CIBERESP), Spain., Joshi PK; Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, UK., Boh ETH; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore, Singapore., Ntalla I; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece., Pitkänen N; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland., Mahajan A; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., van Leeuwen EM; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands., Joro R; Institute of Biomedicine, Physiology, University of Eastern Finland, Kuopio, Finland., Lagou V; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; KUL - University of Leuven, Department of Neurosciences, Leuven, Belgium.; Translational Immunology Laboratory, VIB, Leuven, Belgium., Nodzenski M; Department of Preventive Medicine, Division of Biostatistics, Feinberg School of Medicine, Northwestern University, Chicago, USA., Diver LA; Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Zondervan KT; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; Endometriosis CaRe Centre, Nuffield Department of Obstetrics & Gynaecology, University of Oxford, Oxford, UK., Bustamante M; ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; CIBER de Epidemiología y Salud Pública (CIBERESP), Spain.; Center for Genomic Regulation (CRG), Barcelona, Spain., Marques-Vidal P; Department of Internal Medicine, Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland., Mercader JM; Joint BSC-CRG-IRB Research Program in Computational Biology, Barcelona Supercomputing Center, Barcelona, Spain., Bennett AJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Rahmioglu N; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Nyholt DR; Institute of Health and Biomedical Innovation, Queensland University of Technology, Queensland, Australia., Ma RCW; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong, China.; Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China., Tam CHT; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong, China., Tam WH; Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong, Hong Kong, China., Ganesh SK; Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA., van Rooij FJ; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands., Jones SE; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, UK., Loh PR; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA., Ruth KS; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, UK., Tuke MA; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, UK., Tyrrell J; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, UK.; European Centre for Environment and Human Health, University of Exeter, Truro, UK., Wood AR; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, UK., Yaghootkar H; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, UK., Scholtens DM; Department of Preventive Medicine, Division of Biostatistics, Feinberg School of Medicine, Northwestern University, Chicago, USA., Paternoster L; Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; School of Social and Community Medicine, University of Bristol, Bristol, UK., Prokopenko I; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; Department of Genomics of Common Disease, School of Public Health, Imperial College London, London, UK., Kovacs P; IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany., Atalay M; Institute of Biomedicine, Physiology, University of Eastern Finland, Kuopio, Finland., Willems SM; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands., Panoutsopoulou K; Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK., Wang X; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore, Singapore., Carstensen L; Department of Epidemiology Research, Statens Serum Institute, Copenhagen, Denmark., Geller F; Department of Epidemiology Research, Statens Serum Institute, Copenhagen, Denmark., Schraut KE; Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, UK., Murcia M; CIBER de Epidemiología y Salud Pública (CIBERESP), Spain.; FISABIO-Universitat Jaume I-Universitat de València, Joint Research Unit of Epidemiology and Environmental Health, Valencia, Spain., van Beijsterveldt CE; Netherlands Twin Register, Department of Biological Psychology, VU University, Amsterdam, the Netherlands., Willemsen G; Netherlands Twin Register, Department of Biological Psychology, VU University, Amsterdam, the Netherlands., Appel EVR; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Fonvig CE; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; The Children's Obesity Clinic, Department of Pediatrics, Copenhagen University Hospital Holbæk, Holbæk, Denmark., Trier C; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; The Children's Obesity Clinic, Department of Pediatrics, Copenhagen University Hospital Holbæk, Holbæk, Denmark., Tiesler CM; Institute of Epidemiology I, Helmholtz Zentrum München- German Research Center for Environmental Health, Neuherberg, Germany.; Division of Metabolic and Nutritional Medicine, Dr. von Hauner Children's Hospital, University of Munich Medical Center, Munich, Germany., Standl M; Institute of Epidemiology I, Helmholtz Zentrum München- German Research Center for Environmental Health, Neuherberg, Germany., Kutalik Z; Swiss Institute of Bioinformatics, Lausanne, Switzerland.; Institute of Social and Preventive Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland., Bonas-Guarch S; Joint BSC-CRG-IRB Research Program in Computational Biology, Barcelona Supercomputing Center, Barcelona, Spain., Hougaard DM; Danish Center for Neonatal Screening, Statens Serum Institute, Copenhagen, Denmark.; Department for Congenital Disorders, Statens Serum Institute, Copenhagen, Denmark., Sánchez F; Joint BSC-CRG-IRB Research Program in Computational Biology, Barcelona Supercomputing Center, Barcelona, Spain.; Computer Sciences Department, Barcelona Supercomputing Center, Barcelona, Spain., Torrents D; Joint BSC-CRG-IRB Research Program in Computational Biology, Barcelona Supercomputing Center, Barcelona, Spain.; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain., Waage J; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., Hollegaard MV; Danish Center for Neonatal Screening, Statens Serum Institute, Copenhagen, Denmark.; Department for Congenital Disorders, Statens Serum Institute, Copenhagen, Denmark., de Haan HG; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Rosendaal FR; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Medina-Gomez C; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, the Netherlands.; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, the Netherlands., Ring SM; Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; School of Social and Community Medicine, University of Bristol, Bristol, UK., Hemani G; Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; School of Social and Community Medicine, University of Bristol, Bristol, UK., McMahon G; School of Social and Community Medicine, University of Bristol, Bristol, UK., Robertson NR; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Groves CJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Langenberg C; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Luan J; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Scott RA; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Zhao JH; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Mentch FD; Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., MacKenzie SM; Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Reynolds RM; BHF Centre for Cardiovascular Science, University of Edinburgh, Queen's Medical Research Institute, Edinburgh, Scotland, UK., Lowe WL Jr; Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, USA., Tönjes A; Medical Department, University of Leipzig, Leipzig, Germany., Stumvoll M; IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany.; Medical Department, University of Leipzig, Leipzig, Germany., Lindi V; Institute of Biomedicine, Physiology, University of Eastern Finland, Kuopio, Finland., Lakka TA; Institute of Biomedicine, Physiology, University of Eastern Finland, Kuopio, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland., van Duijn CM; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands., Kiess W; Pediatric Research Center, Department of Women´s & Child Health, University of Leipzig, Leipzig, Germany., Körner A; IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany.; Pediatric Research Center, Department of Women´s & Child Health, University of Leipzig, Leipzig, Germany., Sørensen TI; Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; School of Social and Community Medicine, University of Bristol, Bristol, UK.; Novo Nordisk Foundation Center for Basic Metabolic Research and Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark., Niinikoski H; Department of Pediatrics, Turku University Hospital, Turku, Finland.; Department of Physiology, University of Turku, Turku, Finland., Pahkala K; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Paavo Nurmi Centre, Sports and Exercise Medicine Unit, Department of Physical Activity and Health, Turku, Finland., Raitakari OT; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland., Zeggini E; Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK., Dedoussis GV; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece., Teo YY; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore, Singapore.; Department of Statistics and Applied Probability, National University of Singapore, Singapore, Singapore.; Life Sciences Institute, National University of Singapore, Singapore, Singapore., Saw SM; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore, Singapore.; Singapore Eye Research Institute, Singapore, Singapore., Melbye M; Department of Epidemiology Research, Statens Serum Institute, Copenhagen, Denmark.; Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark.; Department of Medicine, Stanford School of Medicine, Stanford, California, USA., Campbell H; Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, UK., Wilson JF; Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, UK.; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, UK., Vrijheid M; ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; CIBER de Epidemiología y Salud Pública (CIBERESP), Spain., de Geus EJ; Netherlands Twin Register, Department of Biological Psychology, VU University, Amsterdam, the Netherlands.; EMGO Institute for Health and Care Research, VU University and VU University Medical Center, Amsterdam, the Netherlands., Boomsma DI; Netherlands Twin Register, Department of Biological Psychology, VU University, Amsterdam, the Netherlands., Kadarmideen HN; Department of Large Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Holm JC; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; The Children's Obesity Clinic, Department of Pediatrics, Copenhagen University Hospital Holbæk, Holbæk, Denmark., Hansen T; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Sebert S; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.; Biocenter Oulu, University of Oulu, Finland., Hattersley AT; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, UK., Beilin LJ; School of Medicine and Pharmacology, Royal Perth Hospital Unit, The University of Western Australia, Perth, Australia., Newnham JP; School of Women's and Infants' Health, The University of Western Australia, Perth, Australia., Pennell CE; School of Women's and Infants' Health, The University of Western Australia, Perth, Australia., Heinrich J; Institute of Epidemiology I, Helmholtz Zentrum München- German Research Center for Environmental Health, Neuherberg, Germany.; Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Inner City Clinic, University Hospital Munich, Ludwig Maximilian University of Munich, Munich, Germany., Adair LS; Department of Nutrition, University of North Carolina, Chapel Hill, NC, USA., Borja JB; USC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City, Philippines.; Department of Nutrition and Dietetics, University of San Carlos, Cebu City, Philippines., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Eriksson JG; National Institute for Health and Welfare, Helsinki, Finland.; Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Folkhälsan Research Center, Helsinki, Finland., Widén EE; Institute for Molecular Medicine, Finland (FIMM), University of Helsinki, Helsinki, Finland., Kähönen M; Department of Clinical Physiology, Tampere University Hopital, Tampere, Finland.; Department of Clinical Physiology, University of Tampere School of Medicine, Tampere, Finland., Viikari JS; Division of Medicine, Turku University Hospital, Turku, Finland.; Department of Medicine, University of Turku, Turku, Finland., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, Finland., Vollenweider P; Department of Internal Medicine, Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland., Bønnelykke K; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., Bisgaard H; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., Mook-Kanamori DO; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands.; Epidemiology Section, BESC Department, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia., Hofman A; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, the Netherlands.; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands., Rivadeneira F; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, the Netherlands.; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, the Netherlands., Uitterlinden AG; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, the Netherlands.; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, the Netherlands., Pisinger C; Research Center for Prevention and Health Capital Region, Center for Sundhed, Rigshospitalet - Glostrup, Copenhagen University, Glostrup, Denmark., Pedersen O; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Power C; Population, Policy and Practice, UCL Institute of Child Health, University College London, London, UK., Hyppönen E; Population, Policy and Practice, UCL Institute of Child Health, University College London, London, UK.; Centre for Population Health Research, School of Health Sciences, and Sansom Institute, University of South Australia, Adelaide, Australia.; South Australian Health and Medical Research Institute, Adelaide, Australia., Wareham NJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Hakonarson H; Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Davies E; Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Walker BR; BHF Centre for Cardiovascular Science, University of Edinburgh, Queen's Medical Research Institute, Edinburgh, Scotland, UK., Jaddoe VW; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, the Netherlands.; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands.; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, the Netherlands., Jarvelin MR; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.; Biocenter Oulu, University of Oulu, Finland.; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment & Health, School of Public Health, Imperial College London, London, UK.; Unit of Primary Care, Oulu University Hospital, Oulu, Finland., Grant SF; Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Division of Endocrinology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Vaag AA; Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark.; Department of Endocrinology, Rigshospitalet, Copenhagen, Denmark., Lawlor DA; Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; School of Social and Community Medicine, University of Bristol, Bristol, UK., Frayling TM; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, UK., Davey Smith G; Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; School of Social and Community Medicine, University of Bristol, Bristol, UK., Morris AP; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; Department of Biostatistics, University of Liverpool, Liverpool, UK.; Estonian Genome Center, University of Tartu, Tartu, Estonia., Ong KK; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.; Department of Paediatrics, University of Cambridge, Cambridge, UK., Felix JF; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, the Netherlands.; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands.; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, the Netherlands., Timpson NJ; Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; School of Social and Community Medicine, University of Bristol, Bristol, UK., Perry JR; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Evans DM; The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia.; Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; School of Social and Community Medicine, University of Bristol, Bristol, UK., McCarthy MI; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; Oxford National Institute for Health Research (NIHR) Biomedical Research Centre, Churchill Hospital, Oxford, UK., Freathy RM; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, UK.; Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.

Publikováno v: Nature [Nature] 2016 Oct 13; Vol. 538 (7624), pp. 248-252. Date of Electronic Publication: 2016 Sep 28.

Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants.

Autor: van der Valk RJ; The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands.; Department of Pediatrics, Erasmus Medical Center, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands., Duijts L; Department of Pediatrics, Erasmus Medical Center, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.; School of Social and Community Medicine, University of Bristol, Uk., Timpson NJ; School of Social and Community Medicine, University of Bristol, Uk.; MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, UK., Salam MT; Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, USA., Standl M; Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Curtin JA; University of Manchester, Manchester Academic Health Science Centre, University Hospital of South Manchester NHS Foundation Trust, Manchester, United Kingdom., Genuneit J; Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany., Kerhof M; University Medical Center Groningen, University of Groningen, Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital., Kreiner-Møller E; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, The Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.; The Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Copenhagen, Denmark., Cáceres A; Center for Research in Environmental Epidemiology (CREAL), Barcelona, Catalonia, Spain.; Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Catalonia, Spain.; Spanish consortium for Research on Epidemiology and Public Health (CIBERESP), Spain., Gref A; Institute of Environmental Medicine and Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden., Liang LL; Department of Epidemiology, Harvard School of Public Health, Boston, USA.; Department of Biostatistics, Harvard School of Public Health, Boston, USA., Taal HR; The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands.; Department of Pediatrics, Erasmus Medical Center, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands., Bouzigon E; Inserm, UMR 946, Genetic Variation and Human Diseases Unit, F-75010, Paris, France.; Univ Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, F- 75007, Paris, France., Demenais F; Inserm, UMR 946, Genetic Variation and Human Diseases Unit, F-75010, Paris, France.; Univ Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, F- 75007, Paris, France., Nadif R; Inserm, Centre for research in Epidemiology and Population Health (CEPH), U1018, Respiratory and Environmental Epidemiology Team, F-94807, Villejuif, France.; Univ Paris-Sud, UMRS 1018, F-94807, Villejuif, France., Ober C; Department of Human Genetics, University of Chicago, Chicago, IL 60637., Thompson EE; Department of Human Genetics, University of Chicago, Chicago, IL 60637., Estrada K; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands., Hofman A; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands., Uitterlinden AG; The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands., van Duijn C; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands., Rivadeneira F; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands., Li X; Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, USA., Eckel SP; Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, USA., Berhane K; Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, USA., Gauderman WJ; Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, USA., Granell R; School of Social and Community Medicine, University of Bristol, Uk., Evans DM; School of Social and Community Medicine, University of Bristol, Uk.; MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, UK., St Pourcain B; School of Social and Community Medicine, University of Bristol, Uk., McArdle W; School of Social and Community Medicine, University of Bristol, Uk., Kemp JP; School of Social and Community Medicine, University of Bristol, Uk.; MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, UK., Smith GD; School of Social and Community Medicine, University of Bristol, Uk.; MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, UK., Tiesler CM; Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Flexeder C; Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Simpson A; University of Manchester, Manchester Academic Health Science Centre, University Hospital of South Manchester NHS Foundation Trust, Manchester, United Kingdom., Murray CS; University of Manchester, Manchester Academic Health Science Centre, University Hospital of South Manchester NHS Foundation Trust, Manchester, United Kingdom., Fuchs O; Inselspital, Universitätsspital, Bern, Universitätklinik für Kinderheilkunde, Bern, Switzerland.; Dr. von Hauner Children's Hospital, Ludwig Maximilian University, Munich, Germany., Postma DS; University of Groningen, University Medical Center Groningen, Department of Pulmonology, Groningen, The Netherlands.; Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Bønnelykke K; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, The Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.; The Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Copenhagen, Denmark., Torrent M; Spanish consortium for Research on Epidemiology and Public Health (CIBERESP), Spain.; ib-salut, Area de Salut de Menorca, Balearic Islands, Spain., Andersson M; Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.; Department of Physiology, South Central Hospital, Stockholm, Sweden., Sleiman P; Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Hakonarson H; Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Cookson WO; National Heart and Lung Institute, Imperial College London, London SW3 6LY., Moffatt MF; National Heart and Lung Institute, Imperial College London, London SW3 6LY., Paternoster L; School of Social and Community Medicine, University of Bristol, Uk.; MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, UK., Melén E; Institute of Environmental Medicine and Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden.; Sach's Children's Hospital, Stockholm, Sweden., Sunyer J; Center for Research in Environmental Epidemiology (CREAL), Barcelona, Catalonia, Spain.; Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Catalonia, Spain.; Spanish consortium for Research on Epidemiology and Public Health (CIBERESP), Spain.; Pompeu Fabra University (UPF), Barcelona, Catalonia, Spain., Bisgaard H; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, The Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.; The Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Copenhagen, Denmark., Koppelman GH; University Medical Center Groningen, University of Groningen, Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital.; University of Groningen, University Medical Center Groningen, Department of Pulmonology, Groningen, The Netherlands.; Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Ege M; Dr. von Hauner Children's Hospital, Ludwig Maximilian University, Munich, Germany., Custovic A; University of Manchester, Manchester Academic Health Science Centre, University Hospital of South Manchester NHS Foundation Trust, Manchester, United Kingdom., Heinrich J; Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Gilliland FD; Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, USA., Henderson AJ; School of Social and Community Medicine, University of Bristol, Uk., Jaddoe VW; The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands.; Department of Pediatrics, Erasmus Medical Center, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands., de Jongste JC; Department of Pediatrics, Erasmus Medical Center, Rotterdam, The Netherlands.

Publikováno v: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2014 Jul; Vol. 134 (1), pp. 46-55. Date of Electronic Publication: 2013 Dec 06.