Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Tiesler, CMT"'
Autor:
Couto Alves, A, De Silva, NMG, Karhunen, V, Sovio, U, Das, S, Taal, HR, Warrington, NM, Lewin, AM, Kaakinen, M, Cousminer, DL, Thiering, E, Timpson, NJ, Bond, TA, Lowry, E, Brown, CD, Estivill, X, Lindi, V, Bradfield, JP, Geller, F, Speed, D, Coin, LJM, Loh, M, Barton, SJ, Beilin, LJ, Bisgaard, H, Bønnelykke, K, Alili, R, Hatoum, IJ, Schramm, K, Cartwright, R, Charles, M, Salerno, V, Clément, K, Claringbould, AAJ, BIOS Consortium, van Duijn, CM, Moltchanova, E, Eriksson, JG, Elks, C, Feenstra, B, Flexeder, C, Franks, S, Frayling, TM, Freathy, RM, Elliott, P, Widén, E, Hakonarson, H, Hattersley, AT, Rodriguez, A, Banterle, M, Heinrich, J, Heude, B, Holloway, JW, Hofman, A, Hyppönen, E, Inskip, H, Kaplan, LM, Hedman, AK, Läärä, E, Prokisch, H, Grallert, H, Lakka, TA, Lawlor, DA, Melbye, M, Ahluwalia, TS, Marinelli, M, Millwood, IY, Palmer, LJ, Pennell, CE, Perry, JR, Ring, SM, Savolainen, MJ, Rivadeneira, F, Standl, M, Sunyer, J, Tiesler, CMT, Uitterlinden, AG, Schierding, W, O’Sullivan, JM, Prokopenko, I, Herzig, K, Smith, GD, O'Reilly, P, Felix, JF, Buxton, JL, Blakemore, AIF, Ong, KK, Jaddoe, VWV, Grant, SFA, Sebert, S, McCarthy, MI, Järvelin, M., Early Growth Genetics (EGG) Consortium
Publikováno v:
Science Advances
Copyright © 2019 The Authors. Early childhood growth patterns are associated with adult health, yet the genetic factors and the developmental stages involved are not fully understood. Here, we combine genome-wide association studies with modeling of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::c10978d62a197230afd68f4b4b8d7adf
https://researchonline.lshtm.ac.uk/id/eprint/4654552/1/eaaw3095.full.pdf
https://researchonline.lshtm.ac.uk/id/eprint/4654552/1/eaaw3095.full.pdf
Autor:
Paternoster, L, Standl, M, Waage, J, Baurecht, H, Hotze, M, Strachan, DP, Curtin, JA, Bonnelykke, K, Tian, C, Takahashi, A, Esparza-Gordillo, J, Alves, AC, Thyssen, JP, den Dekker, HT, Ferreira, MA, Altmaier, E, Sleiman, PMA, Xiao, FL, Gonzalez, JR, Marenholz, I, Kalb, B, Pino-Yanes, M, Xu, C-J, Carstensen, L, Groen-Blokhuis, MM, Venturini, C, Pennell, CE, Barton, SJ, Levin, AM, Curjuric, I, Bustamante, M, Kreiner-Moller, E, Lockett, GA, Bacelis, J, Bunyavanich, S, Myers, RA, Matanovic, A, Kumar, A, Tung, JY, Hirota, T, Kubo, M, McArdle, WL, Henderson, AJ, Kemp, JP, Zheng, J, Smith, GD, Rueschendorf, F, Bauerfeind, A, Lee-Kirsch, MA, Arnold, A, Homuth, G, Schmidt, CO, Mangold, E, Cichon, S, Keil, T, Rodriguez, E, Peters, A, Franke, A, Lieb, W, Novak, N, Foelster-Holst, R, Horikoshi, M, Pekkanen, J, Sebert, S, Husemoen, LL, Grarup, N, De Jongste, JC, Rivadeneira, F, Hofman, A, Jaddoe, VWV, Pasmans, SGMA, Elbert, NJ, Uitterlinden, AG, Marks, GB, Thompson, PJ, Matheson, MC, Robertson, CF, Ried, JS, Li, J, Zuo, XB, Zheng, XD, Yin, XY, Sun, LD, McAleer, MA, O'Regan, GM, Fahy, CMR, Campbell, LE, Macek, M, Kurek, M, Hu, D, Eng, C, Postma, DS, Feenstra, B, Geller, F, Hottenga, JJ, Middeldorp, CM, Hysi, P, Bataille, V, Spector, T, Tiesler, CMT, Thiering, E, Pahukasahasram, B, Yang, JJ, Imboden, M, Huntsman, S, Vilor-Tejedor, N, Relton, CL, Myhre, R, Nystad, W, Custovic, A, Weiss, ST, Meyers, DA, Soederhaell, C, Melen, E, Ober, C, Raby, BA, Simpson, A, Jacobsson, B, Holloway, JW, Bisgaard, H, Sunyer, J, Probst-Hensch, NM, Williams, LK, Godfrey, KM, Wang, CA, Boomsma, DI, Melbye, M, Koppelman, GH, Jarvis, D, McLean, WHI, Irvine, AD, Zhang, XJ, Hakonarson, H, Gieger-, C, Burchard, EG, Martin, NG, Duijts, L, Linneberg, A, Jarvelin, M-R, Noethen, MM, Lau, S, Huebner, N, Lee, Y-A, Tamari, M, Hinds, DA, Glass, D, Brown, SJ, Heinrich, J, Evans, DM, Weidinger, S, AAGC, AAGC, Epidemio, EGL
Publikováno v:
Nature Genetics
Genetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common, complex skin disease, we performed a meta-analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::fe015907bf2695c75e6d9e570aa8583c
https://openaccess.sgul.ac.uk/id/eprint/107705/7/NG-LE40675R1_Paternoster_200815_with_fig.pdf
https://openaccess.sgul.ac.uk/id/eprint/107705/7/NG-LE40675R1_Paternoster_200815_with_fig.pdf
Autor:
Vimaleswaran, KS, Cavadino, A, Berry, DJ, Jorde, R, Dieffenbach, AK, Lu, C, Alves, AC, Heerspink, HJL, Tikkanen, E, Eriksson, J, Wong, A, Mangino, M, Jablonski, KA, Nolte, IM, Houston, DK, Ahluwalia, TS, Van der Most, PJ, Pasko, D, Zgaga, L, Thiering, E, Vitart, V, Fraser, RM, Huffman, JE, De Boer, RA, Schoettker, B, Saum, K-U, McCarthy, MI, Dupuis, J, Herzig, K-H, Sebert, S, Pouta, A, Laitinen, J, Kleber, ME, Navis, G, Lorentzon, M, Jameson, K, Arden, N, Cooper, JA, Acharya, J, Hardy, R, Raitakari, O, Ripatti, S, Billings, LK, Lahti, J, Osmond, C, Penninx, BW, Rejnmark, L, Lohman, KK, Paternoster, L, Stolk, RP, Hernandez, DG, Byberg, L, Hagstrom, E, Melhus, H, Ingelsson, E, Mellstroem, D, Ljunggren, O, Tzoulaki, I, McLachlan, S, Theodoratou, E, Tiesler, CMT, Jula, A, Navarro, P, Wright, AF, Polasek, O, Hayward, C, Wilson, JF, Rudan, I, Salomaa, V, Heinrich, J, Campbell, H, Price, JF, Karlsson, M, Lind, L, Michaesson, K, Bandinelli, S, Frayling, TM, Hartman, CA, Sorensen, TIA, Kritchevsky, SB, Langdahl, BL, Eriksson, JG, Florez, JC, Spector, TD, Lehtimaki, T, Kuh, D, Humphries, SE, Cooper, C, Ohlsson, C, Maerz, W, De Borst, MH, Kumari, M, Kivimaki, M, Wang, TJ, Power, C, Brenner, H, Grimnes, G, Van der Harst, P, Snieder, H, Hingorani, AD, Pilz, S, Whittaker, JC, Jarvelin, M-R, Hypponen, E
Background Low plasma 25-hydroxyvitamin D (25[OH]D) concentration is associated with high arterial blood pressure and hypertension risk, but whether this association is causal is unknown. We used a mendelian randomisation approach to test whether 25(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::917c8b8fa3aaae478997a72d46c42591
Autor:
Vimaleswaran, Kerani S., Cavadino, Alana, Berry, Diane J., Jorde, Rolf, Grimnes, Guri, Dieffenbach, Aida Karina, Lu, Chen, Alves, Alexessander Couto, Heerspink, Hiddo J. Lambers, Tikkanen, Emmi, Eriksson, Joel, Wong, Andrew, Mangino, Massimo, Jablonski, Kathleen A., Nolte, Ilja M., Houston, Denise K., Ahluwalia, Tarunveer Singh, van der Most, Peter J., Pasko, Dorota, Zgaga, Lina, Thiering, Elisabeth, Schöttker, B, Saum, KU, Brenner, H, Järvelin, MR, Tzoulaki, I, Snieder, H, Stolk, RP, Hartman, CA, de Boer, RA, van der Harst, P, Navis, G, de Borst, MH, Lorentzon, M, Mellström, D, Ohlsson, C, Hardy, R, Kuh, D, Cooper, JA, Acharya, J, Humphries, SE, Hingorani, AD, Kumari, M, Kivimaki, M, Spector, TD, Kritchevsky, SB, Lohman, KK, Sørensen, TIA, Frayling, TM, Campbell, H, Theodoratou, E, Fraser, RM, Wilson, JF, Rudan, I, Price, JF, McLachlan, S, Vitart, V, Navarro, P, Huffman, JE, Hayward, C, Wright, AF, Tiesler, CMT, Heinrich, J, McCarthy, MI, Ingelsson, E, Arden, N, Cooper, C, Dupuis, J, Herzig, KH, Sebert, S, Pouta, A, Laitinen, J, Kleber, ME, März, W, Jameson, K, Osmond, C, Raitakari, O, Ripatti, S, Lahti, J, Eriksson, JG, Penninx, BW, Billings, LK, Florez, JC, Rejnmark, L, Langdahl, BL, Paternoster, L, Hernandez, DG, Byberg, L, Michaelsson, K, Hagström, E, Melhus, H, Ljunggren, O, Lind, L, Jula, A, Polasek, O, Salomaa, V, Karlsson, M, Bandinelli, S, Lehtimäki, T, Wang, TJ, Pilz, S, Whittaker, JC
Background Low plasma 25-hydroxyvitamin D (25[OH]D) concentration is associated with high arterial blood pressure and hypertension risk, but whether this association is causal is unknown. We used a mendelian randomisation approach to test whether 25(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::046177db6e4ac83b92bcf83af933c962
https://hdl.handle.net/10037/25398
https://hdl.handle.net/10037/25398
Autor:
Horikoshi, M, Yaghootkar, H, Mook, Dennis, Sovio, U, Taal, Rob, Hennig, BJ, Bradfield, JP, St Pourcain, B, Evans, DM, Charoen, P, Kaakinen, M, Cousminer, DL, Lehtimaki, T, Kreiner-Moller, E, Warrington, NM, Bustamante, M, Feenstra, B, Berry, DJ, Thiering, E, Pfab, T, Barton, SJ, Shields, BM, Kerkhof, M, Leeuwen, Elisa, Fulford, AJ, Kutalik, Z, Zhao, JH, den Hoed, M, Mahajan, A, Lindi, V, Goh, LK, Hottenga, JJ (Jouke Jan), Wu, Fenny, Raitakari, OT, Harder, M, Meirhaeghe, A, Ntalla, I, Salem, RM, Jameson, KA, Zhou, K, Monies, D, Lagou, V, Kirin, M, Heikkinen, J, Adair, LS, Alkuraya, FS, Al-Odaib, A, Amouyel, P, Andersson, EAS, Bennett, AJ, Blakemore, AIF, Buxton, JL, Dallongeville, J, Das, Suman, de Geus, EJC, Estivill, X, Flexeder, C, Froguel, P, Geller, F, Godfrey, KM, Gottrand, F, Groves, CJ, Hansen, T, Hirschhorn, JN, Hofman, Bert, Hollegaard, MV, Hougaard, DM, Hypponen, E, Inskip, H, Isaacs, Aaron, Jorgensen, T, Kanaka-Gentenbein, C, Kemp, JP, Kiess, W, Kipelainen, TO, Klopp, N, Knight, BA, Kuzawa, CW, McMahon, G, Newnham, JP, Niinikoski, H, Oostra, Ben, Pedersen, L, Postma, DS, Ring, SM, Rivadeneira, Fernando, Robertson, NR, Sebert, S, Simell, O, Slowinski, T, Tiesler, CMT, Tonjes, A, Vaag, A, Viikari, JS, Vink, JM, Vissing, NH, Wareham, NJ, Willemsen, G, Witte, DR, Zhang, H, Zhao, J, Wilson, JF, Stumvoll, M, Prentice, AM, Meyer, BF, Pearson, ER, Boreham, CA, Cooper, C, Gilman, MW, Dedoussis, GV, Moreno, LA, Pedersen, O, Saarinen, M, Mohlke, KL, Boomsma, DI, Saw, SM, Lakka, TA, Korner, A, Loos, RJ, Ong, KK, Vollenweider, P, Duijn, Cornelia, Koppelman, GH, Hattersley, AT, Holloway, JW, Hocher, B, Heinrich, J, Power, C, Melbye, M, Guxens Junyent, Monica, Pennell, CE, Bonnelykke, K, Bisgaard, H, Eriksson, JG, Widen, E, Hakonarson, H, Uitterlinden, André, Pouta, A, Lawlor, DA, Smith, GD, Frayling, TM, McCarthy, M, Grant, SFA, Jaddoe, Vincent, Jarvelin, MR, Timpson, NJ, Prokopenko, I, Freathy, RM
Publikováno v:
Nature Genetics, 45, 76-82. Nature Publishing Group
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::141f79d35f58a215718138f5c5868d16
https://pure.eur.nl/en/publications/e12b1a88-bb4f-455d-9d9b-d25466b010a4
https://pure.eur.nl/en/publications/e12b1a88-bb4f-455d-9d9b-d25466b010a4
Autor:
Horikoshi, M, Beaumont, RN, Day, FR, Warrington, NM, Kooijman, MN, Fernandez-Tajes, J, Feenstra, B, Van Zuydam, NR, Gaulton, KJ, Grarup, N, Bradfield, JP, Strachan, DP, Li-Gao, R, Ahluwalia, TS, Kreiner, E, Rueedi, R, Lyytikäinen, L-P, Cousminer, DL, Wu, Y, Thiering, E, Wang, CA, Have, CT, Hottenga, J-J, Vilor-Tejedor, N, Joshi, PK, Boh, ETH, Ntalla, I, Pitkänen, N, Mahajan, A, Van Leeuwen, EM, Joro, R, Lagou, V, Nodzenski, M, Diver, LA, Zondervan, KT, Bustamante, M, Marques-Vidal, P, Mercader, JM, Bennett, AJ, Rahmioglu, N, Nyholt, DR, Ma, RCW, Tam, CHT, Tam, WH, CHARGE Consortium Hematology Working Group, Ganesh, SK, Van Rooij, FJA, Jones, SE, Loh, P-R, Ruth, KS, Tuke, MA, Tyrrell, J, Wood, AR, Yaghootkar, H, Scholtens, DM, Paternoster, L, Prokopenko, I, Kovacs, P, Atalay, M, Willems, SM, Panoutsopoulou, K, Wang, X, Carstensen, L, Geller, F, Schraut, KE, Murcia, M, Van Beijsterveldt, CEM, Willemsen, G, Appel, EVR, Fonvig, CE, Trier, C, Tiesler, CMT, Standl, M, Kutalik, Z, Bonàs-Guarch, S, Hougaard, DM, Sánchez, F, Torrents, D, Waage, J, Hollegaard, MV, De Haan, HG, Rosendaal, FR, Medina-Gomez, C, Ring, SM, Hemani, G, McMahon, G, Robertson, NR, Groves, CJ, Langenberg, C, Luan, J, Scott, RA, Zhao, JH, Mentch, FD, MacKenzie, SM, Reynolds, RM, Early Growth Genetics (EGG) Consortium, Lowe, WL, Tönjes, A, Stumvoll, M, Lindi, V, Lakka, TA, Van Duijn, CM, Kiess, W, Körner, A, Sørensen, TIA, Niinikoski, H, Pahkala, K, Raitakari, OT, Zeggini, E, Dedoussis, GV, Teo, Y-Y, Saw, S-M, Melbye, M, Campbell, H, Wilson, JF, Vrijheid, M, De Geus, EJCN, Boomsma, DI, Kadarmideen, HN, Holm, J-C, Hansen, T, Sebert, S, Hattersley, AT, Beilin, LJ, Newnham, JP, Pennell, CE, Heinrich, J, Adair, LS, Borja, JB, Mohlke, KL, Eriksson, JG, Widén, E, Kähönen, M, Viikari, JS, Lehtimäki, T, Vollenweider, P, Bønnelykke, K, Bisgaard, H, Mook-Kanamori, DO, Hofman, A, Rivadeneira, F, Uitterlinden, AG, Pisinger, C, Pedersen, O, Power, C, Hyppönen, E, Wareham, NJ, Hakonarson, H, Davies, E, Walker, BR, Jaddoe, VWV, Järvelin, M-R, Grant, SFA, Vaag, AA, Lawlor, DA, Frayling, TM, Smith, GD, Morris, AP, Ong, KK, Felix, JF, Timpson, NJ, Perry, JRB, Evans, DM, McCarthy, MI, Freathy, RM
Birth weight (BW) has been shown to be influenced by both fetal and maternal factors and in observational studies is reproducibly associated with future risk of adult metabolic diseases including type 2 diabetes (T2D) and cardiovascular disease. Thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::483e251ff8fc46c3579cdd9855a0acd3
Autor:
Neumann A; Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada., Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Pappa I; Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Rotterdam, The Netherlands., Ahluwalia TS; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.; Steno Diabetes Center Copenhagen, Gentofte, Denmark., Pettersson E; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Rodriguez A; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom., Whitehouse A; Telethon Kids Institute, University of Western Australia, Perth, Australia., van Beijsterveldt CEM; Netherlands Twin Register, Dept Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands., Benyamin B; Australian Centre for Precision Health, University of South Australia Cancer Research Institute, School of Health Sciences, University of South Australia, Adelaide, Australia.; South Australian Health and Medical Research Institute, Adelaide, Australia., Hammerschlag AR; Child Health Research Centre, University of Queensland, Brisbane, QLD, Australia.; Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Public Health Research Institute, Amsterdam, The Netherlands., Helmer Q; Netherlands Twin Register, Dept Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands., Karhunen V; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.; Centre for Life-Course Health Research, University of Oulu, Oulu, Finland., Krapohl E; Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom., Lu Y; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., van der Most PJ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Palviainen T; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland., St Pourcain B; MRC Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.; Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherland.; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands., Seppälä I; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Suarez A; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Vilor-Tejedor N; Center for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.; BarcelonaBeta Brain Research Center (BBRC)-Pasqual Maragall Foundation, Barcelona, Spain.; Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands.; Universitat Pompeu Fabra (UPF), Barcelona, Spain., Tiesler CMT; Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; LMU-Ludwig-Maximilians-Universität Munich, Div. Metabolic and Nutritional Medicine, Dr. von Hauner Children's Hospital, University of Munich Medical Center, Munich, Germany., Wang C; School of Medicine and Public Health, Faculty of Medicine and Health, The University of Newcastle, Newcastle, New South Wales, Australia., Wills A; Division of Substance Dependence, Department of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, CO, United States of America.; Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, United States of America., Zhou A; Australian Centre for Precision Health, University of South Australia Cancer Research Institute, School of Health Sciences, University of South Australia, Adelaide, Australia.; South Australian Health and Medical Research Institute, Adelaide, Australia., Alemany S; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.; CIBER Epidemiology and Public Health (CIBERESP), Barcelona, Spain., Bisgaard H; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., Bønnelykke K; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., Davies GE; Avera Institute for Human Genetics, Sioux Falls, South Dakota, United States of America., Hakulinen C; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Henders AK; Institute of Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia., Hyppönen E; Australian Centre for Precision Health, University of South Australia Cancer Research Institute, School of Health Sciences, University of South Australia, Adelaide, Australia.; South Australian Health and Medical Research Institute, Adelaide, Australia.; Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London, United Kingdom., Stokholm J; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.; Department of Pediatrics, Naestved Hospital, Naestved, Denmark., Bartels M; Netherlands Twin Register, Dept Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands., Hottenga JJ; Netherlands Twin Register, Dept Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands., Heinrich J; LMU-Ludwig-Maximilians-Universität Munich, Div. Metabolic and Nutritional Medicine, Dr. von Hauner Children's Hospital, University of Munich Medical Center, Munich, Germany.; Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, LMU Munich, Munich, Germany., Hewitt J; Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, United States of America.; Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, United States of America., Keltikangas-Järvinen L; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Korhonen T; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland., Kaprio J; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland., Lahti J; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Lahti-Pulkkinen M; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Middeldorp CM; Child Health Research Centre, University of Queensland, Brisbane, QLD, Australia.; Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Child and Youth Mental Health Service, Children's Health Queensland Hospital and Health Service, Brisbane, QLD, Australia., Najman JM; Public Health, University of Queensland, Brisbane, QLD, Australia., Pennell C; School of Medicine and Public Health, Faculty of Medicine and Health, The University of Newcastle, Newcastle, New South Wales, Australia., Power C; Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London, United Kingdom., Oldehinkel AJ; Interdisciplinary Center Psychopathology and Emotion Regulation (IPCE), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Plomin R; Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom., Räikkönen K; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Raitakari OT; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland., Rimfeld K; Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom., Sass L; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.; Department of Pediatrics, Naestved Hospital, Naestved, Denmark., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Standl M; LMU-Ludwig-Maximilians-Universität Munich, Div. Metabolic and Nutritional Medicine, Dr. von Hauner Children's Hospital, University of Munich Medical Center, Munich, Germany., Sunyer J; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.; CIBER Epidemiology and Public Health (CIBERESP), Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain., Williams GM; Child and Youth Mental Health Service, Children's Health Queensland Hospital and Health Service, Brisbane, QLD, Australia., Bakermans-Kranenburg MJ; Clinical Child & Family Studies, Vrije Universiteit Amsterdam, The Netherlands., Boomsma DI; Netherlands Twin Register, Dept Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands., van IJzendoorn MH; School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom., Hartman CA; Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Tiemeier H; Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Social and Behavioral Science, Harvard TH Chan School of Public Health, Boston, MA, United States of America.
Publikováno v:
PloS one [PLoS One] 2022 Aug 22; Vol. 17 (8), pp. e0273116. Date of Electronic Publication: 2022 Aug 22 (Print Publication: 2022).
Autor:
Huang T; Key Laboratory of Molecular Cardiovascular Sciences, Peking University, Ministry of Education, Beijing, China.; Department of Global Health, School of Public Health, Peking University, Beijing, China.; Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China., Wang T; Shanghai Institute of Endocrine and Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.; Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana., Zheng Y; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.; School of Life Sciences, Fudan University, Shanghai, China., Ellervik C; Department of Research and Innovation Region Zealand, Region Zealand, Denmark.; Division of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Laboratory Medicine, Boston Children's Hospital, Boston, Massachusetts.; Department of Pathology, Harvard Medical School, Boston, Massachusetts., Li X; Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana., Gao M; Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China., Fang Z; Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China., Chai JF; Saw Swee Hock School of Public Health, National University of Singapore, Singapore., Ahluwalia TVS; Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.; Steno Diabetes Center Copenhagen, Gentofte, Denmark., Wang Y; Department of Epidemiology, University of North Carolina, Chapel Hill., Voortman T; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, Netherlands., Noordam R; Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, Netherlands., Frazier-Wood A; Children's Nutrition Research Center, Baylor College of Medicine, Houston, Texas., Scholz M; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany., Sonestedt E; Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden., Akiyama M; RIKEN Center for Integrative Medical Sciences, Laboratory for Statistical Analysis, Yokohama, Japan., Dorajoo R; Genome Institute of Singapore, Agency for Science Technology and Research, Singapore., Zhou A; Centre for Population Health Research, School of Health Sciences, University of South Australia, Adelaide, Australia.; Sansom Institute of Health Research, University of South Australia, Adelaide, Australia., Kilpeläinen TO; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Kleber ME; Competence Cluster of Nutrition and Cardiovascular Health, Halle-Jena-Leipzig, Germany.; Institute of Nutrition, Friedrich Schiller University, Jena, Germany.; Vth Department of Medicine, Mannheim Medical Faculty, Heidelberg University, Mannheim, Germany., Crozier SR; MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, United Kingdom., Godfrey KM; MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, United Kingdom.; NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, University of Southampton, Southampton, United Kingdom., Lemaitre R; Cardiovascular Health Research Institute, Department of Medicine, University of Washington, Seattle., Felix JF; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands., Shi Y; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore., Gupta P; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore., Khor CC; Genome Institute of Singapore, Agency for Science Technology and Research, Singapore., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center, Tampere, Finland.; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Wang CA; Division of Obstetrics and Gynaecology, School of Medicine, University of Western Australia, Crawley, Western Australia, Australia.; Department of Obstetrics and Gynecology, School of Medicine and Public Health, The University of Newcastle, Callaghan, New South Wales, Australia., Tiesler CMT; Ludwig-Maximilians-University of Munich, Dr von Hauner Children's Hospital, Division of Metabolic Diseases and Nutritional Medicine, Munich, Germany.; Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Thiering E; Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Division of Metabolic and Nutritional Medicine, Dr von Hauner Children's Hospital, Klinikum der Universitaet Muenchen, Munich, Germany., Standl M; Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Rzehak P; Division of Metabolic and Nutritional Medicine, Dr von Hauner Children's Hospital, Klinikum der Universitaet Muenchen, Munich, Germany., Marouli E; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom., He M; MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China., Lecoeur C; University of Lille Nord de France, Lille, France.; Institut Pasteur de Lille, Lille, France., Corella D; Department of Preventive Medicine and Public Health, University of Valencia, Valencia, Spain.; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain., Lai CQ; United States Department of Agriculture Research Service, Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts., Moreno LA; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain.; Growth Exercise, Nutrition and Development Research Group, Facultad de Ciencias de la Salud, Universidad de Zaragoza, Zaragoza, Spain., Pitkänen N; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland., Boreham CA; UCD Institute for Sport & Health, University College Dublin, Dublin, Ireland., Zhang T; Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana.; Department of Biostatistics, School of Public Health, Shandong University, Jinan, China., Saw SM; Saw Swee Hock School of Public Health, National University of Singapore, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore., Ridker PM; Division of Preventive Medicine, Brigham & Women's Hospital, Boston, Massachusetts., Graff M; Department of Epidemiology, University of North Carolina, Chapel Hill., van Rooij FJA; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, Netherlands., Uitterlinden AG; Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands., Hofman A; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, Netherlands.; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts., van Heemst D; Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, Netherlands., Rosendaal FR; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands., de Mutsert R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands., Burkhardt R; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.; Institute for Laboratory Medicine, University of Leipzig, Leipzig, Germany., Schulz CA; Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden., Ericson U; Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden., Kamatani Y; RIKEN Center for Integrative Medical Sciences, Laboratory for Statistical Analysis, Yokohama, Japan., Yuan JM; Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania.; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania., Power C; Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London, United Kingdom., Hansen T; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Sørensen TIA; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Public Health, Section of Epidemiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; MRC Integrative Epidemiology Unit & School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom., Tjønneland A; Danish Cancer Society Research Center, Copenhagen, Denmark., Overvad K; Department of Public Health, Section for Epidemiology, Aarhus University, Aarhus, Denmark.; Aalborg University Hospital, Aalborg, Denmark., Delgado G; Vth Department of Medicine, Mannheim Medical Faculty, Heidelberg University, Mannheim, Germany., Cooper C; MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, United Kingdom.; NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, University of Southampton, Southampton, United Kingdom.; Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, The Botnar Research Centre, University of Oxford, Oxford, United Kingdom., Djousse L; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Rivadeneira F; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands., Jameson K; MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, United Kingdom., Zhao W; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore., Liu J; Saw Swee Hock School of Public Health, National University of Singapore, Singapore.; Genome Institute of Singapore, Agency for Science Technology and Research, Singapore., Lee NR; USC Office of Population Studies Foundation Inc, University of San Carlos, Cebu City, Philippines.; Department of Anthropology, Sociology, and History, University of San Carlos, Cebu City, Philippines., Raitakari O; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland., Kähönen M; Department of Clinical Physiology, Tampere University Hospital, and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Viikari J; Division of Medicine, Turku University Hospital, Turku, Finland.; Department of Medicine, University of Turku, Turku, Finland., Grote V; Division of Metabolic and Nutritional Medicine, Dr von Hauner Children's Hospital, Klinikum der Universitaet Muenchen, Munich, Germany., Langhendries JP; Department of Paediatrics and NICU, CHC-Site St-Vincent, Liège-Rocourt, Belgium., Koletzko B; Division of Metabolic and Nutritional Medicine, Dr von Hauner Children's Hospital, Klinikum der Universitaet Muenchen, Munich, Germany., Escribano J; Paediatrics Research Unit, Universitat Rovira i Virgili, IISPV, Reus, Spain., Verduci E; Department of Pediatrics, San Paolo Hospital, University of Milan, Milan, Italy., Dedoussis G; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece., Yu C; MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China., Tham YC; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore., Lim B; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Lim SH; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore., Froguel P; University of Lille Nord de France, Lille, France.; Institut Pasteur de Lille, Lille, France.; University of Lille Nord de France, Lille, France., Balkau B; INSERM, Centre for Research in Epidemiology and Population Health, Villejuif, France.; University Versailles Saint-Quentin-en-Yvelines, Versailles, France.; University Paris Sud 11, Villejuif, France., Fink NR; Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., Vinding RK; Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., Sevelsted A; Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., Bisgaard H; Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., Coltell O; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain.; Department of Computer Languages and Systems, University Jaume I, Castellon, Spain., Dallongeville J; INSERM U1167, Institut Pasteur de Lille, University of Lille, Lille, France., Gottrand F; INSERM U995, Hôpital Jeanne de Flandre, CHU-Lille, University of Lille, Lille, France., Pahkala K; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Paavo Nurmi Centre, Sports and Exercise Medicine Unit, Department of Physical Activity and Health, Turku, Finland., Niinikoski H; Department of Pediatrics, Turku University Hospital, Turku, Finland.; Department of Physiology, University of Turku, Turku, Finland., Hyppönen E; Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.; Australian Centre for Precision Health, University of South Australia Cancer Research Institute, University of South Australia, Adelaide, Australia.; South Australian Health and Medical Research Institute, Adelaide, Australia., Pedersen O; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., März W; Vth Department of Medicine, Mannheim Medical Faculty, Heidelberg University, Mannheim, Germany.; Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany.; Clinical Institute of Medical and Chemical Laboratory Diagnostics Medical University of Graz, Graz, Austria., Inskip H; MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, United Kingdom.; NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, University of Southampton, Southampton, United Kingdom., Jaddoe VWV; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands., Dennison E; MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, United Kingdom.; Victoria University of Wellington, Wellington, New Zealand., Wong TY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore., Sabanayagam C; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore., Tai ES; Saw Swee Hock School of Public Health, National University of Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Health Services and Systems Research, Duke-NUS Medical School, Singapore., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill., Mackey DA; Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Crawley, Western Australia, Australia., Gruszfeld D; Department of Neonatology and Neonatal Intensive Care, The Children's Memorial Health Institute, Al. Dzieci Polskich 20, Warsaw, Poland., Deloukas P; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD) King Abdulaziz University, Jeddah, Saudi Arabia., Tucker KL; Biomedical and Nutritional Sciences, University of Massachusetts, Lowell., Fumeron F; INSERM, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France.; University of Paris Diderot, Sorbonne Paris Cité, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France.; Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France., Bønnelykke K; Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., Rossing P; Steno Diabetes Center Copenhagen, Gentofte, Denmark., Estruch R; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain.; Department of Internal Medicine, Hospital Clinic, IDIBAPS, Barcelona, Spain., Ordovas JM; United States Department of Agriculture Research Service, Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts.; Department of Epidemiology and Population Genetics, Centro Nacional Investigación, Cardiovasculares (CNIC), Madrid, Spain., Arnett DK; College of Public Health, University of Kentucky, Lexington., Meirhaeghe A; INSERM U1167, Institut Pasteur de Lille, University of Lille, Lille, France., Amouyel P; INSERM U1167, Institut Pasteur de Lille, University of Lille, Lille, France., Cheng CY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore., Sim X; Saw Swee Hock School of Public Health, National University of Singapore, Singapore., Teo YY; Saw Swee Hock School of Public Health, National University of Singapore, Singapore.; Department of Statistics and Applied Probability, Faculty of Science, National University of Singapore, Singapore., van Dam RM; Saw Swee Hock School of Public Health, National University of Singapore, Singapore., Koh WP; Saw Swee Hock School of Public Health, National University of Singapore, Singapore.; Health Services and Systems Research, Duke-NUS Medical School, Singapore., Orho-Melander M; Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden., Loeffler M; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany., Kubo M; RIKEN Center for Integrative Medical Sciences, Laboratory for Statistical Analysis, Yokohama, Japan., Thiery J; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.; Institute for Laboratory Medicine, University of Leipzig, Leipzig, Germany., Mook-Kanamori DO; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands.; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, Netherlands., Mozaffarian D; Friedman School of Nutrition Science & Policy, Tufts University, Boston, Massachusetts., Psaty BM; Cardiovascular Health Research Institute, Department of Medicine, University of Washington, Seattle.; Department of Epidemiology, University of Washington, Seattle.; Department of Health Sciences, University of Washington, Seattle.; Kaiser Permanent Washington Health Research Institute, Seattle., Franco OH; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, Netherlands., Wu T; MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China., North KE; Department of Epidemiology, University of North Carolina, Chapel Hill.; Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill., Davey Smith G; MRC Integrative Epidemiology Unit & School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom., Chavarro JE; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts., Chasman DI; Division of Preventive Medicine, Brigham & Women's Hospital, Boston, Massachusetts.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Qi L; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.; Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana.
Publikováno v:
JAMA network open [JAMA Netw Open] 2019 Sep 04; Vol. 2 (9), pp. e1910915. Date of Electronic Publication: 2019 Sep 04.
Autor:
Couto Alves A; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Surrey, UK., De Silva NMG; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK., Karhunen V; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK., Sovio U; Department of Obstetrics and Gynaecology, University of Cambridge, Cambridge, UK.; NIHR Cambridge Biomedical Research Centre, Cambridge, UK., Das S; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; MRC Unit for Lifelong Health and Ageing at UCL, University College London, London, UK., Taal HR; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.; Department of Paediatrics, Erasmus MC, Sophia Children's Hospital, Rotterdam, Netherlands., Warrington NM; Division of Obstetrics and Gynaecology, The University of Western Australia, Perth, Western Australia, Australia.; The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, Queensland, Australia., Lewin AM; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, UK., Kaakinen M; Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK.; Centre for Pharmacology and Therapeutics, Division of Experimental Medicine, Department of Medicine, Imperial College London, Hammersmith Hospital, London, UK.; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Surrey, UK., Cousminer DL; Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Institute of Biomedicine, Department of Physiology, University of Eastern Finland, Kuopio, Finland.; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland., Thiering E; Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich Neuherberg, Germany.; Division of Metabolic Diseases and Nutritional Medicine, Dr von Hauner Children's Hospital, Ludwig-Maximilians University Munich, Munich, Germany., Timpson NJ; MRC Integrative Epidemiology Unit at the University of Bristol and NIHR Bristol Biomedical Research Center, Bristol, UK.; Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK., Bond TA; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK., Lowry E; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland., Brown CD; Department of Genetics and Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Estivill X; Genomics and Disease Group, Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), Barcelona, Catalonia, Spain.; Pompeu Fabra University (UPF), Barcelona, Catalonia, Spain.; Hospital del Mar Medical Research Institute (IMIM), Barcelona, Catalonia, Spain.; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain., Lindi V; Institute of Biomedicine, Department of Physiology, University of Eastern Finland, Kuopio, Finland., Bradfield JP; Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA., Geller F; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark., Speed D; Aarhus Institute of Advanced Studies (AIAS), Aarhus University, Aarhus, Denmark.; UCL Genetics Institute, University College London, London, UK., Coin LJM; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Loh M; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.; Translational Laboratory in Genetic Medicine (TLGM), Agency for Science, Technology and Research (ASTAR) Singapore, Singapore., Barton SJ; MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK.; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK., Beilin LJ; Medical School, Royal Perth Hospital, University of Western Australia, Perth, Western Australia, Australia., Bisgaard H; COPSAC, The Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark., Bønnelykke K; COPSAC, The Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark., Alili R; CRNH Ile de France, Hôpital Pitié-Salpêtrière, Paris, France., Hatoum IJ; CRNH Ile de France, Hôpital Pitié-Salpêtrière, Paris, France.; Obesity, Metabolism, and Nutrition Institute and Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Schramm K; Institute of Human Genetics, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Human Genetics, Technische Universität München, München, Germany., Cartwright R; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; Institute for Reproductive and Developmental Biology, Imperial College London, London, UK., Charles MA; Inserm, UMR 1153 (CRESS), Paris Descartes University, Villejuif, Paris, France., Salerno V; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK., Clément K; CRNH Ile de France, Hôpital Pitié-Salpêtrière, Paris, France.; Inserm, UMR 1153 (CRESS), Paris Descartes University, Villejuif, Paris, France., Claringbould AAJ; University Medical Centre Groningen, Department of Genetics, Antonius Deusinglaan 1, 9713 AV Groningen, Netherlands., van Duijn CM; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands., Moltchanova E; Department of Mathematics and Statistics, University of Canterbury, Christchurch, New Zealand., Eriksson JG; Department of General Practice and Primary Health Care, University of Helsinki, and Helsinki University Hospital, Helsinki, Finland.; Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland.; Folkhalsan Research Center, Helsinki, Finland., Elks C; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK., Feenstra B; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark., Flexeder C; Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich Neuherberg, Germany., Franks S; Institute for Reproductive and Developmental Biology, Imperial College London, London, UK., Frayling TM; Institute of Biomedical and Clinical Science, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital, Exeter, UK., Freathy RM; Institute of Biomedical and Clinical Science, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital, Exeter, UK., Elliott P; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; National Institute for Health Research, Imperial College Biomedical Research Centre, London, UK.; Health Data Research UK London, Imperial College London, London, UK., Widén E; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland., Hakonarson H; Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Institute of Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Hattersley AT; Institute of Biomedical and Clinical Science, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital, Exeter, UK., Rodriguez A; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; School of Psychology, College of Social Science, University of Lincoln Brayford Pool Lincoln, Lincolnshire, UK., Banterle M; Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, UK., Heinrich J; Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich Neuherberg, Germany., Heude B; Inserm, UMR 1153 (CRESS), Paris Descartes University, Villejuif, Paris, France., Holloway JW; Human Genetics and Medical Genomics, Faculty of Medicine, University of Southampton, Southampton, UK., Hofman A; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands., Hyppönen E; South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.; Great Ormond Street Hospital Institute of Child Health, University College London, London, UK.; Australian Centre for Precision Health, University of South Australia Cancer Research Institute, North Terrace, Adelaide, South Australia, Australia., Inskip H; MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK.; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK., Kaplan LM; Obesity, Metabolism, and Nutrition Institute and Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Hedman AK; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institute, Stockholm, Sweden., Läärä E; Research Unit of Mathematical Sciences, University of Oulu, Oulu, Finland., Prokisch H; Institute of Human Genetics, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Human Genetics, Technische Universität München, München, Germany., Grallert H; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Lakka TA; Institute of Biomedicine, Department of Physiology, University of Eastern Finland, Kuopio, Finland.; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland., Lawlor DA; MRC Integrative Epidemiology Unit at the University of Bristol and NIHR Bristol Biomedical Research Center, Bristol, UK.; Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK., Melbye M; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Department of Medicine, Stanford University Medical School, Stanford, CA, USA., Ahluwalia TS; COPSAC, The Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark., Marinelli M; Hospital del Mar Medical Research Institute (IMIM), Barcelona, Catalonia, Spain.; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain.; ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain., Millwood IY; Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), University of Oxford, Old Road Campus, Oxford, UK.; Medical Research Council Population Health Research Unit (MRC PHRU) at the University of Oxford, Oxford, UK., Palmer LJ; School of Public Health and Robinson Research Institute, University of Adelaide, Adelaide, Australia., Pennell CE; Division of Obstetrics and Gynaecology, The University of Western Australia, Perth, Western Australia, Australia., Perry JR; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK., Ring SM; MRC Integrative Epidemiology Unit at the University of Bristol and NIHR Bristol Biomedical Research Center, Bristol, UK.; Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK.; Avon Longitudinal Study of Parents and Children, School of Social and Community Medicine, University of Bristol, Bristol, UK., Savolainen MJ; Division of Internal Medicine, and Biocenter of Oulu, Faculty of Medicine, Oulu University, Oulu, Finland., Rivadeneira F; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands., Standl M; Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich Neuherberg, Germany., Sunyer J; Pompeu Fabra University (UPF), Barcelona, Catalonia, Spain.; Hospital del Mar Medical Research Institute (IMIM), Barcelona, Catalonia, Spain.; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain.; ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain., Tiesler CMT; Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich Neuherberg, Germany.; Division of Metabolic Diseases and Nutritional Medicine, Dr von Hauner Children's Hospital, Ludwig-Maximilians University Munich, Munich, Germany., Uitterlinden AG; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands., Schierding W; Liggins Institute, University of Auckland, Auckland, New Zealand., O'Sullivan JM; Liggins Institute, University of Auckland, Auckland, New Zealand.; A Better Start-National Science, Challenge, University of Auckland, Auckland, New Zealand., Prokopenko I; Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK.; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Surrey, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Headington, Oxford, UK., Herzig KH; Biocenter Oulu, University of Oulu, Oulu, Finland.; Research Unit of Biomedicine, University Oulu, Oulu, Finland.; Medical Research Center and Oulu University Hospital, University of Oulu, Oulu, Finland.; Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences, Poznan, Poland., Smith GD; MRC Integrative Epidemiology Unit at the University of Bristol and NIHR Bristol Biomedical Research Center, Bristol, UK.; Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK., O'Reilly P; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, De Crespigny Park, London, UK., Felix JF; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.; Department of Paediatrics, Erasmus MC, Sophia Children's Hospital, Rotterdam, Netherlands.; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands., Buxton JL; School of Life Sciences, Pharmacy and Chemistry, Kingston University, Kingston upon Thames, UK., Blakemore AIF; Department of Life Sciences, College of Health and Life Sciences, Brunel University London, London, UK.; Section of Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Imperial College London, London, UK., Ong KK; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK., Jaddoe VWV; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands., Grant SFA; Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Institute of Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Sebert S; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.; Biocenter Oulu, University of Oulu, Oulu, Finland., McCarthy MI; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Headington, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK., Järvelin MR; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.; Biocenter Oulu, University of Oulu, Oulu, Finland.; Medical Research Center and Oulu University Hospital, University of Oulu, Oulu, Finland.; Department of Life Sciences, College of Health and Life Sciences, Brunel University London, London, UK.; Unit of Primary Care, Oulu University Hospital, Oulu, Finland.
Publikováno v:
Science advances [Sci Adv] 2019 Sep 04; Vol. 5 (9), pp. eaaw3095. Date of Electronic Publication: 2019 Sep 04 (Print Publication: 2019).
Autor:
Ligthart S; Department of Epidemiology, Erasmus University Medical Center, Rotterdam 3000 CA, the Netherlands., Vaez A; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands; Department of Bioinformatics, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran., Võsa U; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu 51010, Estonia., Stathopoulou MG; Université de Lorraine, INSERM, IGE-PCV, 54000 Nancy, France., de Vries PS; Department of Epidemiology, Erasmus University Medical Center, Rotterdam 3000 CA, the Netherlands; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX 77030, USA., Prins BP; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK., Van der Most PJ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands., Tanaka T; Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21224, USA., Naderi E; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands; Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen 9713 GZ, the Netherlands., Rose LM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA., Wu Y; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA., Karlsson R; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden., Barbalic M; University of Split School of Medicine, Split 21000, Croatia., Lin H; Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA., Pool R; Department of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Amsterdam 1081 BT, the Netherlands; Amsterdam Public Health research institute, VU University Medical Center, Amsterdam 1081 BT, the Netherlands., Zhu G; QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia., Macé A; Department of Computational Biology, University of Lausanne, Lausanne 1010, Switzerland; Swiss Institute of Bioinformatics, Lausanne 1015, Switzerland; Institute of Social and Preventive Medicine, University Hospital of Lausanne, Lausanne 1010, Switzerland., Sidore C; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Sardinia 08045, Italy., Trompet S; Department of Cardiology, Leiden University Medical Center, Leiden 2300 RC, the Netherlands; Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden 2333 ZA, the Netherlands., Mangino M; Department of Twin Research & Genetic Epidemiology, King's College London, London SE1 7EH, UK; NIHR Biomedical Research Centre at Guy's and St. Thomas' Foundation Trust, London SE1 9RT, UK., Sabater-Lleal M; Unit of Genomics of Complex Diseases, Institut d'Investigació Biomèdica Sant Pau, Barcelona 08025, Spain; Cardiovascular Medicine Unit, Department of Medicine, Center for Molecular Medicine, Karolinska Institutet, Stockholm 17176, Sweden., Kemp JP; University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, QLD 4102, Australia; MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol BS8 2BN, UK., Abbasi A; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands; Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen 9713 GZ, the Netherlands; MRC Epidemiology Unit, University of Cambridge School of Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK., Kacprowski T; Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst-Moritz-Arndt University Greifswald, Greifswald 17475, Germany; German Centre for Cardiovascular Research, Partner Site Greifswald, Greifswald 17475, Germany., Verweij N; University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen 9713 AV, the Netherlands., Smith AV; Icelandic Heart Association, Kopavogur 201, Iceland; Faculty of Medicine, University of Iceland, Reykjavik 101, Iceland., Huang T; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA., Marzi C; Institute of Epidemiology II, Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany; German Center for Diabetes Research, Partner Site Munich, Munich 85764, Germany., Feitosa MF; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63108-2212, USA., Lohman KK; Department of Epidemiology and Prevention, Public Health Sciences, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA., Kleber ME; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim 68167, Germany., Milaneschi Y; Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam University Medical Center/GGZ inGeest Research & Innovation, Amsterdam 1081 HJ, the Netherlands., Mueller C; Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg 20246, Germany; Institute of Medical Biometry and Statistics, University Medical Center Schleswig-Holstein, Campus Luebeck, Lübeck 23562, Germany; German Center for Cardiovascular Research, Partner Site RhineMain, 55131 Mainz, Germany., Huq M; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands., Vlachopoulou E; Transplantation Laboratory, Medicum, University of Helsinki, Helsinki 00014, Finland., Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33014, Finland; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere 33520, Finland., Oldmeadow C; Hunter Medical Research Institute, New Lambon Heights, NSW 2305, Australia; Centre for Clinical Epidemiology & Biostatistics, Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia., Deelen J; Molecular Epidemiology, Leiden University Medical Center, Leiden 2333 ZC, the Netherlands; Max Planck Institute for Biology of Ageing, Cologne 50931, Germany., Perola M; National Institute for Health and Welfare, Helsinki 00271, Finland., Zhao JH; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK., Feenstra B; Department of Epidemiology Research, Statens Serum Institut, Copenhagen 2300, Denmark., Amini M; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands., Lahti J; Helsinki Collegium for Advanced Studies, University of Helsinki, Helsinki 00014, Finland; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki 00014, Finland; Folkhälsan Research Centre, Helsinki 00250, Finland., Schraut KE; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH16 4UX, UK., Fornage M; Human Genetics Center, School of Public Health and Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA., Suktitipat B; Department of Biochemistry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand., Chen WM; Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA., Li X; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA., Nutile T; Institute of Genetics and Biophysics 'A. Buzzati-Traverso,' Consiglio Nazionale delle Ricerche, Napoli 80131, Italy., Malerba G; Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona 37134, Italy., Luan J; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK., Bak T; Interdisciplinary Center Psychopathology and Emotion regulation, University Medical Center Groningen, University of Groningen, Groningen 9700 RB, the Netherlands., Schork N; Human Biology, J. Craig Venter Institute, La Jolla, CA 92037, USA; Quantitative Medicine, Translational Genomics Research Institute, Phoenix, AZ 85004, USA., Del Greco M F; Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano 39100, Italy., Thiering E; Institute of Epidemiology, Helmholtz Zentrum München - German Research Centre for Environmental Health, Neuherberg 85764, Germany; Ludwig Maximilian University of Munich, Dr. von Hauner Children's Hospital, Munich 80337, Germany., Mahajan A; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Marioni RE; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK., Mihailov E; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu 51010, Estonia., Eriksson J; Department of Internal Medicine and Clinical Nutrition, University of Gothenburg, Gothenburg 41345, Sweden., Ozel AB; Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109-5618, USA., Zhang W; Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK; Department of Cardiology, Ealing Hospital, Middlesex UB1 3HW, UK., Nethander M; Bioinformatics Core Facility, Sahlgrenska Academy, University of Gothenburg, Gothenburg 413 90, Sweden., Cheng YC; Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Aslibekyan S; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294-0022, USA., Ang W; Medical School, University of Western Australia, Perth, WA 6009, Australia., Gandin I; AREA Science Park, Trieste 34149, Italy., Yengo L; Centre National de la Recherche Scientifique UMR 8199, University of Lille, Institut Pasteur de Lille, European Genomic Institute for Diabetes, FR 3508, 59000 Lille, France; Program in Complex Trait Genomics, Institute for Molecular Bioscience, University of Queensland, St. Lucia, Brisbane, QLD 4072, Australia., Portas L; Support OU, Institute of Genetic and Biomedic Research, Consiglio Nazionale delle Ricerche, Sassari 7100, Italy., Kooperberg C; Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Mail Stop M3-A410, 1100 Fairview Ave. N., Seattle, WA, USA., Hofer E; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University Graz, Graz 8036, Austria; Institute of Medical Informatics, Statistics and Documentation, Medical University Graz, Graz 8036, Austria., Rajan KB; Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA., Schurmann C; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., den Hollander W; Department of Medical Statistics and Bio-informatics, Section Molecular Epidemiology, Leiden University Medical Center, Leiden 2333 ZC, the Netherlands., Ahluwalia TS; Steno Diabetes Center Copenhagen, Gentofte 2820, Denmark; Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2100, Denmark., Zhao J; Center for Integrative Genomics, School of Biology, Georgia Institute of Technology, Atlanta, GA 30332, USA., Draisma HHM; Department of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Amsterdam 1081 BT, the Netherlands; Amsterdam Public Health research institute, VU University Medical Center, Amsterdam 1081 BT, the Netherlands; Neuroscience Campus Amsterdam, Amsterdam 1081 HV, the Netherlands., Ford I; Robertson Centre for Biostatistics, University of Glasgow, Glasgow G12 8QQ, UK., Timpson N; MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol BS8 2BN, UK., Teumer A; Department SHIP-KEF, Institute for Community Medicine, University Medicine Greifswald, Greifswald 17475, Germany., Huang H; Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA., Wahl S; Institute of Epidemiology II, Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany; German Center for Diabetes Research, Partner Site Munich, Munich 85764, Germany., Liu Y; Department of Epidemiology and Prevention, Public Health Sciences, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA., Huang J; Boston VA Research Institute, Inc., Boston, MA 02130, USA., Uh HW; Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden 2333 ZC, the Netherlands., Geller F; Department of Epidemiology Research, Statens Serum Institut, Copenhagen 2300, Denmark., Joshi PK; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH16 4UX, UK., Yanek LR; GeneSTAR Research Center, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Trabetti E; Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona 37134, Italy., Lehne B; Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK., Vozzi D; Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo,' Trieste 34140, Italy., Verbanck M; Centre National de la Recherche Scientifique UMR 8199, University of Lille, Institut Pasteur de Lille, European Genomic Institute for Diabetes, FR 3508, 59000 Lille, France., Biino G; Institute of Molecular Genetics, Consiglio Nazionale delle Ricerche, Pavia 27100, Italy., Saba Y; Gottfried Schatz Research Center, Institute for Molecular Biology and Biochemistry, 8010 Graz, Austria., Meulenbelt I; Department of Medical Statistics and Bio-informatics, Section Molecular Epidemiology, Leiden University Medical Center, Leiden 2333 ZC, the Netherlands., O'Connell JR; Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Laakso M; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio 70210, Finland., Giulianini F; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA., Magnusson PKE; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden., Ballantyne CM; Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA; Methodist DeBakey Heart and Vascular Center, Houston, TX 77030, USA., Hottenga JJ; Department of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Amsterdam 1081 BT, the Netherlands., Montgomery GW; QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia., Rivadineira F; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam 3015 CN, the Netherlands., Rueedi R; Department of Computational Biology, University of Lausanne, Lausanne 1010, Switzerland; Swiss Institute of Bioinformatics, Lausanne 1015, Switzerland., Steri M; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Sardinia 08045, Italy., Herzig KH; Department of Physiology, Institute of Biomedicine, University of Oulu, Medical Research Center Oulu and Oulu University Hospital, Oulu 90014, Finland; Biocenter Oulu, University of Oulu, Oulu 90220, Finland; Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences, Poznan 60-512, Poland., Stott DJ; Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow G12 8QQ, UK., Menni C; Department of Twin Research & Genetic Epidemiology, King's College London, London SE1 7EH, UK., Frånberg M; Cardiovascular Medicine Unit, Department of Medicine, Center for Molecular Medicine, Karolinska Institutet, Stockholm 17176, Sweden; Department of Numerical Analysis and Computer Science, Stockholm University, Stockholm 100 44, Sweden., St Pourcain B; MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol BS8 2BN, UK; Donders Institute, Radboud University, Nijmegen 6525 XD, the Netherlands., Felix SB; German Centre for Cardiovascular Research, Partner Site Greifswald, Greifswald 17475, Germany; Department for Internal Medicine B, University Medicine Greifswald, Greifswald 17475, Germany., Pers TH; Department of Epidemiology Research, Statens Serum Institut, Copenhagen 2300, Denmark; Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2100, Denmark., Bakker SJL; Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen 9713 GZ, the Netherlands., Kraft P; Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA., Peters A; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherber 85764, Germany., Vaidya D; GeneSTAR Research Center, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Delgado G; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim 68167, Germany., Smit JH; Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam University Medical Center/GGZ inGeest Research & Innovation, Amsterdam 1081 HJ, the Netherlands., Großmann V; Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University Mainz, Mainz 55131, Germany., Sinisalo J; Heart and Lung Center, Helsinki University Hospital and Helsinki University, Helsinki 00029, Finland., Seppälä I; Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33014, Finland; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere 33520, Finland., Williams SR; Department of Neurology, University of Virginia, Charlottesville, VA 22908, USA., Holliday EG; Hunter Medical Research Institute, New Lambon Heights, NSW 2305, Australia; Centre for Clinical Epidemiology & Biostatistics, Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia., Moed M; Molecular Epidemiology, Leiden University Medical Center, Leiden 2333 ZC, the Netherlands., Langenberg C; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK., Räikkönen K; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki 00014, Finland., Ding J; Department of Internal Medicine/Geriatrics, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA., Campbell H; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH16 4UX, UK., Sale MM; Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA., Chen YI; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA., James AL; Busselton Population Medical Research Institute, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia; Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia., Ruggiero D; Institute of Genetics and Biophysics 'A. Buzzati-Traverso,' Consiglio Nazionale delle Ricerche, Napoli 80131, Italy; IRCCS Neuromed, Pozzilli (IS) 86077, Italy., Soranzo N; Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK., Hartman CA; Interdisciplinary Center Psychopathology and Emotion regulation, University Medical Center Groningen, University of Groningen, Groningen 9700 RB, the Netherlands., Smith EN; Department of Pediatrics and Rady Children's Hospital, School of Medicine, University of California, San Diego, La Jolla, CA 92037, USA., Berenson GS; Center for Cardiovascular Health, Tulane University, New Orleans, LA 70112, USA., Fuchsberger C; Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano 39100, Italy., Hernandez D; Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD 20892, USA., Tiesler CMT; Institute of Epidemiology, Helmholtz Zentrum München - German Research Centre for Environmental Health, Neuherberg 85764, Germany; Ludwig Maximilian University of Munich, Dr. von Hauner Children's Hospital, Munich 80337, Germany., Giedraitis V; Department of Public Health and Caring Sciences, Molecular Geriatrics, Uppsala University, Uppsala 752 37, Sweden., Liewald D; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK., Fischer K; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu 51010, Estonia., Mellström D; Department of Internal Medicine and Clinical Nutrition, University of Gothenburg, Gothenburg 41345, Sweden., Larsson A; Department of Medical Sciences, Uppsala University, Uppsala 751 41, Sweden., Wang Y; Department of Medicine, Case Cardiovascular Research Institute, Case Western Reserve University, Harrington Heart & Vascular Institute, University Hospitals, Cleveland, OH 44106, USA., Scott WR; Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK., Lorentzon M; Department of Internal Medicine and Clinical Nutrition, University of Gothenburg, Gothenburg 41345, Sweden; Geriatric Medicine, Sahlgrenska University Hospital, Mölndal 431 80, Sweden., Beilby J; PathWest Laboratory Medicine WA, Nedlands, WA 6009, Australia; School of Biomedical Sciences, University of Western Australia, Crawley, Perth, WA 6009, Australia., Ryan KA; Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Pennell CE; Medical School, University of Western Australia, Perth, WA 6009, Australia., Vuckovic D; Medical Sciences, Surgical and Health Department, University of Trieste, Trieste 34137, Italy., Balkau B; INSERM U1018, Centre de Recherche en Epidémiologie et Santé des Populations, Team 5 (EpReC, Renal, and Cardiovascular Epidemiology), Université de Versailles Saint-Quentin-en-Yvelines, Université Paris-Saclay, Villejuif 94807, France., Concas MP; Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo,' Trieste 34140, Italy., Schmidt R; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University Graz, Graz 8036, Austria., Mendes de Leon CF; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA., Bottinger EP; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Kloppenburg M; Department of Rheumatology, Leiden University Medical Center, Leiden 2300 RC, the Netherlands; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden 2333 ZC, the Netherlands., Paternoster L; MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol BS8 2BN, UK., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA., Musk AW; Busselton Population Medical Research Institute, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia; Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia., Willemsen G; Department of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Amsterdam 1081 BT, the Netherlands., Evans DM; University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, QLD 4102, Australia; MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol BS8 2BN, UK., Madden PAF; Department of Psychiatry, Washington University School of Medicine, 4560 Clayton Ave., Suite 1000, St. Louis, MO 63110, USA., Kähönen M; Department of Clinical Physiology, Tampere University Hospital, Tampere 33520, Finland; Department of Clinical Physiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere 33520, Finland., Kutalik Z; Swiss Institute of Bioinformatics, Lausanne 1015, Switzerland; Institute of Social and Preventive Medicine, University Hospital of Lausanne, Lausanne 1010, Switzerland., Zoledziewska M; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Sardinia 08045, Italy., Karhunen V; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, 90014 Oulun yliopisto, Finland., Kritchevsky SB; Gerontology and Geriatric Medicine, Sticht Center on Aging and Rehabilitation, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA., Sattar N; BHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, Glasgow G12 8TA, UK., Lachance G; Department of Twin Research & Genetic Epidemiology, King's College London, London SE1 7EH, UK., Clarke R; Clinical Trial Service Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK., Harris TB; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, MD 20892, USA., Raitakari OT; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku 20520, Finland; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku 20520, Finland., Attia JR; Hunter Medical Research Institute, New Lambon Heights, NSW 2305, Australia; Centre for Clinical Epidemiology & Biostatistics, Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia; John Hunter Hospital, New Lambton Heights, NWS 2305, Australia., van Heemst D; Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden 2333 ZA, the Netherlands., Kajantie E; Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki 00014, Finland; Hospital for Children and Adolescents, Helsinki University Central Hospital and University of Helsinki, Helsinki 00290, Finland; Department of Obstetrics and Gynaecology, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu 90014, Finland., Sorice R; Institute of Genetics and Biophysics 'A. Buzzati-Traverso,' Consiglio Nazionale delle Ricerche, Napoli 80131, Italy., Gambaro G; Division of Nephrology and Dialysis, Columbus-Gemelli University Hospital, Università Cattolica del Sacro Cuore, Roma 168, Italy., Scott RA; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK., Hicks AA; Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano 39100, Italy., Ferrucci L; Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21224, USA., Standl M; Institute of Epidemiology, Helmholtz Zentrum München - German Research Centre for Environmental Health, Neuherberg 85764, Germany., Lindgren CM; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7FZ, UK; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, USA., Starr JM; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK; Alzheimer's Scotland Dementia Research Centre, University of Edinburgh, Edinburgh EH8 9JZ, UK., Karlsson M; Department of Clinical Sciences and Orthopaedic Surgery, Lund University, Malmo 20502, Sweden., Lind L; Department of Medical Sciences, Uppsala University, Uppsala 751 41, Sweden., Li JZ; Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109-5618, USA., Chambers JC; Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK; Department of Cardiology, Ealing Hospital, Middlesex UB1 3HW, UK; Imperial College Healthcare NHS Trust, London W12 0HS, UK; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore; MRC-PHE Centre for Environment and Health, Imperial College London, London W2 1PG, UK., Mori TA; Medical School, University of Western Australia, Perth, WA 6009, Australia., de Geus EJCN; Department of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Amsterdam 1081 BT, the Netherlands; Amsterdam Public Health research institute, VU University Medical Center, Amsterdam 1081 BT, the Netherlands., Heath AC; Department of Psychiatry, Washington University School of Medicine, 4560 Clayton Ave., Suite 1000, St. Louis, MO 63110, USA., Martin NG; QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia., Auvinen J; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, 90014 Oulun yliopisto, Finland; Unit of Primary Health Care, Oulu University Hospital, Oulu 90220, Finland., Buckley BM; Department of Epidemiology and Public Health, University College Cork, Cork T12 K8AF, Ireland., de Craen AJM; Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden 2333 ZA, the Netherlands., Waldenberger M; Institute of Epidemiology II, Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany; German Center for Cardiovascular Research, Partner Site Munich Heart Alliance, 80636 Munich, Germany., Strauch K; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany; Genetic Epidemiology, Institute of Medical Informatics, Biometry, and Epidemiology, Faculty of Medicine, Ludwig Maximilian University of Munich, Neuherberg 85764, Germany., Meitinger T; Institute of Human Genetics, Technische Universität München, Munich 85764, Germany; Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg 85764, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich 81377, Germany., Scott RJ; Hunter Medical Research Institute, New Lambon Heights, NSW 2305, Australia; Information-Based Medicine Stream, Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia., McEvoy M; Hunter Medical Research Institute, New Lambon Heights, NSW 2305, Australia; Centre for Clinical Epidemiology & Biostatistics, Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia., Beekman M; Molecular Epidemiology, Leiden University Medical Center, Leiden 2333 ZC, the Netherlands., Bombieri C; Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona 37134, Italy., Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA., Pedersen NL; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden., Morrison AC; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX 77030, USA., Boomsma DI; Department of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Amsterdam 1081 BT, the Netherlands., Whitfield JB; QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia., Strachan DP; Population Health Research Institute, St. George's, University of London, London SW17 0RE, UK., Hofman A; Department of Epidemiology, Erasmus University Medical Center, Rotterdam 3000 CA, the Netherlands., Vollenweider P; Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne 1011, Switzerland., Cucca F; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Sardinia 08045, Italy., Jarvelin MR; Biocenter Oulu, University of Oulu, Oulu 90220, Finland; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, 90014 Oulun yliopisto, Finland; Unit of Primary Health Care, Oulu University Hospital, Oulu 90220, Finland; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment & Health, School of Public Health, Imperial College London, London W2 1PG, UK; Department of Life Sciences, College of Health and Life Sciences, Brunel University London, Kingston Lane, Uxbridge, Middlesex UB8 3PH, UK., Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden 2300 RC, the Netherlands; Durrer Center for Cardiogenetic Research, Amsterdam 3501 DG, the Netherlands; Interuniversity Cardiology Institute of the Netherlands, Utrecht 3511 EP, the Netherlands., Spector TD; Department of Twin Research & Genetic Epidemiology, King's College London, London SE1 7EH, UK., Hamsten A; Cardiovascular Medicine Unit, Department of Medicine, Center for Molecular Medicine, Karolinska Institutet, Stockholm 17176, Sweden., Zeller T; Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg 20246, Germany; German Center for Cardiovascular Research, Partner Site RhineMain, 55131 Mainz, Germany., Uitterlinden AG; Department of Epidemiology, Erasmus University Medical Center, Rotterdam 3000 CA, the Netherlands; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam 3015 CN, the Netherlands., Nauck M; German Centre for Cardiovascular Research, Partner Site Greifswald, Greifswald 17475, Germany; Institute for Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald 17475, Germany., Gudnason V; Icelandic Heart Association, Kopavogur 201, Iceland; Faculty of Medicine, University of Iceland, Reykjavik 101, Iceland., Qi L; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA., Grallert H; Institute of Epidemiology II, Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany; German Center for Diabetes Research, Partner Site Munich, Munich 85764, Germany., Borecki IB; Analytical Genetics Group, Regeneron Genetics Center, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA., Rotter JI; Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA., März W; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim 68167, Germany; Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim 68161, Germany; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz 8036, Austria., Wild PS; German Center for Cardiovascular Research, Partner Site RhineMain, 55131 Mainz, Germany; Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University Mainz, Mainz 55131, Germany; Preventive Cardiology and Preventive Medicine, Center for Cardiology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz 55131, Germany., Lokki ML; Transplantation Laboratory, Medicum, University of Helsinki, Helsinki 00014, Finland., Boyle M; John Hunter Hospital, New Lambton Heights, NWS 2305, Australia., Salomaa V; National Institute for Health and Welfare, Helsinki 00271, Finland., Melbye M; Department of Epidemiology Research, Statens Serum Institut, Copenhagen 2300, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen 2300, Denmark; Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Eriksson JG; National Institute for Health and Welfare, Helsinki 00271, Finland; Folkhälsan Research Centre, Helsinki 00250, Finland; Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki 00014, Finland., Wilson JF; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH16 4UX, UK; MRC Human Genetics Unit, Institute for Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK., Penninx BWJH; Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam University Medical Center/GGZ inGeest Research & Innovation, Amsterdam 1081 HJ, the Netherlands., Becker DM; GeneSTAR Research Center, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Worrall BB; Departments of Neurology and Public Health Sciences, University of Virginia Charlottesville, Charlottesville, VA 22908-0394, USA., Gibson G; Center for Integrative Genomics, School of Biology, Georgia Institute of Technology, Atlanta, GA 30332, USA., Krauss RM; Children's Hospital Oakland Research Institute, Oakland, CA 94609, USA., Ciullo M; Institute of Genetics and Biophysics 'A. Buzzati-Traverso,' Consiglio Nazionale delle Ricerche, Napoli 80131, Italy; IRCCS Neuromed, Pozzilli (IS) 86077, Italy., Zaza G; Renal Unit, Department of Medicine, Verona University Hospital, Verona 37126, Italy., Wareham NJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK., Oldehinkel AJ; Interdisciplinary Center Psychopathology and Emotion regulation, University Medical Center Groningen, University of Groningen, Groningen 9700 RB, the Netherlands., Palmer LJ; School of Public Health, University of Adelaide, Adelaide, SA 5000, Australia., Murray SS; Department of Pathology, University of California, San Diego, San Diego, CA 92121, USA., Pramstaller PP; Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano 39100, Italy; General Central Hospital, Department of Neurology, Bolzano 39100, Italy; Department of Neurology, University of Lübeck, Lübeck 23538, Germany., Bandinelli S; Geriatric Unit, Azienda Sanitaria Firenze, Florence 50122, Italy., Heinrich J; Institute of Epidemiology, Helmholtz Zentrum München - German Research Centre for Environmental Health, Neuherberg 85764, Germany; Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, LMU Munich, Comprehensive Pneumology Center Munich, Member DZL, German Center for Lung Research, 81377 Munich, Germany., Ingelsson E; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala 751 41, Sweden; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford Cardiovascular Institute, Stanford University, Stanford, CA 94305, USA., Deary IJ; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK; Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK., Mägi R; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu 51010, Estonia., Vandenput L; Department of Internal Medicine and Clinical Nutrition, University of Gothenburg, Gothenburg 41345, Sweden., van der Harst P; University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen 9713 AV, the Netherlands., Desch KC; Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI 48109, USA., Kooner JS; Department of Cardiology, Ealing Hospital, Middlesex UB1 3HW, UK; Imperial College Healthcare NHS Trust, London W12 0HS, UK; MRC-PHE Centre for Environment and Health, Imperial College London, London W2 1PG, UK; National Heart and Lung Institute, Imperial College London, London W12 0NN, UK., Ohlsson C; Department of Internal Medicine and Clinical Nutrition, University of Gothenburg, Gothenburg 41345, Sweden., Hayward C; MRC Human Genetics Unit, Institute for Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33014, Finland; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere 33520, Finland., Shuldiner AR; Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Arnett DK; University of Kentucky, College of Public Health, Lexington, KY 40508, USA., Beilin LJ; Medical School, University of Western Australia, Perth, WA 6009, Australia., Robino A; Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo,' Trieste 34140, Italy., Froguel P; Centre National de la Recherche Scientifique UMR 8199, University of Lille, Institut Pasteur de Lille, European Genomic Institute for Diabetes, FR 3508, 59000 Lille, France; Department of Genomics of Common Disease, School of Public Health, Imperial College London, London SW7 2AZ, UK., Pirastu M; Support OU, Institute of Genetic and Biomedic Research, Consiglio Nazionale delle Ricerche, Sassari 7100, Italy., Jess T; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg 2200, Denmark., Koenig W; German Center for Cardiovascular Research, Partner Site Munich Heart Alliance, 80636 Munich, Germany; Department of Internal Medicine II-Cardiology, University of Ulm Medical Center, 80801 Ulm, Germany; Deutsches Herzzentrum München, Technische Universität München, 80636 Munich, Germany., Loos RJF; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029-6542, USA., Evans DA; Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA., Schmidt H; Department of Neurology, Medical University Graz, Graz 8010, Austria; Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Graz 8010, Austria., Smith GD; MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol BS8 2BN, UK., Slagboom PE; Molecular Epidemiology, Leiden University Medical Center, Leiden 2333 ZC, the Netherlands., Eiriksdottir G; Icelandic Heart Association, Kopavogur 201, Iceland., Morris AP; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Department of Biostatistics, University of Liverpool, Liverpool L69 3GL, UK., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA; Department of Epidemiology, University of Washington, Seattle, WA 98101, USA; Department of Health Services, University of Washington, Seattle, WA 98195-7660, USA; Kaiser Permanente Washington Health Research Institute, Seattle, WA 98101, USA., Tracy RP; Department of Pathology, University of Vermont, Colchester, VT 05405, USA., Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands., Boerwinkle E; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX 77030, USA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA., Visvikis-Siest S; Université de Lorraine, INSERM, IGE-PCV, 54000 Nancy, France., Reiner AP; Department of Epidemiology, University of Washington, Seattle, WA 98101, USA., Gross M; Department of Lab Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA., Franke L; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands., Franco OH; Department of Epidemiology, Erasmus University Medical Center, Rotterdam 3000 CA, the Netherlands; Institute of Social and Preventive Medicine, University of Bern, 3012 Bern, Switzerland., Benjamin EJ; Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA; National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA 01702, USA., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA., Dupuis J; National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA 01702, USA; Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands., Dehghan A; Department of Epidemiology, Erasmus University Medical Center, Rotterdam 3000 CA, the Netherlands; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment & Health, School of Public Health, Imperial College London, London W2 1PG, UK. Electronic address: a.dehghan@imperial.ac.uk., Alizadeh BZ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands. Electronic address: b.z.alizadeh@umcg.nl.
Publikováno v:
American journal of human genetics [Am J Hum Genet] 2018 Nov 01; Vol. 103 (5), pp. 691-706.