Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Tierney Kauffman"'
Autor:
Rosa Lapalombella, James S. Blachly, John C. Byrd, Pearlly Yan, Deepa Sampath, Lapo Alinari, Nicole R. Grieselhuber, Daniel Canfield, Larry Beaver, Tierney Kauffman, Amy M. Lehman, Hannah Phillips, Matthew Cannon, Allison Mustonen, Shaneice Mitchell, Wing Keung Chan, Youssef Youssef, Samuel K. Kulp, Christopher C. Coss, Alice S. Mims, Lai Tzung-Huei, Shelley Orwick, Steven Sher, Katie Williams, Lindsey T. Brinton, Pu Zhang
Knockdown of selected genes has modest effects on MOLM13 responses to KPT-9274 treatment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88e089686f0f043cf55ed77ea029b663
https://doi.org/10.1158/1078-0432.22484258.v1
https://doi.org/10.1158/1078-0432.22484258.v1
Autor:
Rosa Lapalombella, James S. Blachly, John C. Byrd, Pearlly Yan, Deepa Sampath, Lapo Alinari, Nicole R. Grieselhuber, Daniel Canfield, Larry Beaver, Tierney Kauffman, Amy M. Lehman, Hannah Phillips, Matthew Cannon, Allison Mustonen, Shaneice Mitchell, Wing Keung Chan, Youssef Youssef, Samuel K. Kulp, Christopher C. Coss, Alice S. Mims, Lai Tzung-Huei, Shelley Orwick, Steven Sher, Katie Williams, Lindsey T. Brinton, Pu Zhang
Mutant IDH1/2 enhances AR-42/KPT-9274 combination sensitivity in a 2-HG-dependent manner.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8878f08d4c78f8ccd77275528e5aaa31
https://doi.org/10.1158/1078-0432.22484249
https://doi.org/10.1158/1078-0432.22484249
Autor:
Rosa Lapalombella, James S. Blachly, John C. Byrd, Pearlly Yan, Deepa Sampath, Lapo Alinari, Nicole R. Grieselhuber, Daniel Canfield, Larry Beaver, Tierney Kauffman, Amy M. Lehman, Hannah Phillips, Matthew Cannon, Allison Mustonen, Shaneice Mitchell, Wing Keung Chan, Youssef Youssef, Samuel K. Kulp, Christopher C. Coss, Alice S. Mims, Lai Tzung-Huei, Shelley Orwick, Steven Sher, Katie Williams, Lindsey T. Brinton, Pu Zhang
Combinations of AR-42 and KPT-9274 have no overlapping toxicities in vivo.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0729589cec9339c4b7720583a082ee5d
https://doi.org/10.1158/1078-0432.22484246.v1
https://doi.org/10.1158/1078-0432.22484246.v1
Autor:
Rosa Lapalombella, James S. Blachly, John C. Byrd, Pearlly Yan, Deepa Sampath, Lapo Alinari, Nicole R. Grieselhuber, Daniel Canfield, Larry Beaver, Tierney Kauffman, Amy M. Lehman, Hannah Phillips, Matthew Cannon, Allison Mustonen, Shaneice Mitchell, Wing Keung Chan, Youssef Youssef, Samuel K. Kulp, Christopher C. Coss, Alice S. Mims, Lai Tzung-Huei, Shelley Orwick, Steven Sher, Katie Williams, Lindsey T. Brinton, Pu Zhang
HDAC8-specific inhibitor (PCI-34051) or AR-42 treatments sensitize AML cell lines to KPT-9274 treatment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::797a070cbc30e95672b9193404afbb5f
https://doi.org/10.1158/1078-0432.22484255
https://doi.org/10.1158/1078-0432.22484255
Autor:
Rosa Lapalombella, James S. Blachly, John C. Byrd, Pearlly Yan, Deepa Sampath, Lapo Alinari, Nicole R. Grieselhuber, Daniel Canfield, Larry Beaver, Tierney Kauffman, Amy M. Lehman, Hannah Phillips, Matthew Cannon, Allison Mustonen, Shaneice Mitchell, Wing Keung Chan, Youssef Youssef, Samuel K. Kulp, Christopher C. Coss, Alice S. Mims, Lai Tzung-Huei, Shelley Orwick, Steven Sher, Katie Williams, Lindsey T. Brinton, Pu Zhang
Purpose:Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors (NAMPTi) are currently in development, but may be limited as single-agent therapy due to compound-specific toxicity and cancer metabolic plasticity allowing resistance development. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fb93244d92585ade19bc491075e0227
https://doi.org/10.1158/1078-0432.c.6531362.v1
https://doi.org/10.1158/1078-0432.c.6531362.v1
Autor:
Rosa Lapalombella, James S. Blachly, John C. Byrd, Pearlly Yan, Deepa Sampath, Lapo Alinari, Nicole R. Grieselhuber, Daniel Canfield, Larry Beaver, Tierney Kauffman, Amy M. Lehman, Hannah Phillips, Matthew Cannon, Allison Mustonen, Shaneice Mitchell, Wing Keung Chan, Youssef Youssef, Samuel K. Kulp, Christopher C. Coss, Alice S. Mims, Lai Tzung-Huei, Shelley Orwick, Steven Sher, Katie Williams, Lindsey T. Brinton, Pu Zhang
AR-42 and KPT-9274 treatments induce DNA repair defects.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e17a455773333236ff5816642e9d5058
https://doi.org/10.1158/1078-0432.22484243.v1
https://doi.org/10.1158/1078-0432.22484243.v1
Autor:
Rosa Lapalombella, James S. Blachly, John C. Byrd, Pearlly Yan, Deepa Sampath, Lapo Alinari, Nicole R. Grieselhuber, Daniel Canfield, Larry Beaver, Tierney Kauffman, Amy M. Lehman, Hannah Phillips, Matthew Cannon, Allison Mustonen, Shaneice Mitchell, Wing Keung Chan, Youssef Youssef, Samuel K. Kulp, Christopher C. Coss, Alice S. Mims, Lai Tzung-Huei, Shelley Orwick, Steven Sher, Katie Williams, Lindsey T. Brinton, Pu Zhang
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74f97f72a1132c12ed8622df6bb0ae38
https://doi.org/10.1158/1078-0432.22484240
https://doi.org/10.1158/1078-0432.22484240
Autor:
Rosa Lapalombella, James S. Blachly, John C. Byrd, Pearlly Yan, Deepa Sampath, Lapo Alinari, Nicole R. Grieselhuber, Daniel Canfield, Larry Beaver, Tierney Kauffman, Amy M. Lehman, Hannah Phillips, Matthew Cannon, Allison Mustonen, Shaneice Mitchell, Wing Keung Chan, Youssef Youssef, Samuel K. Kulp, Christopher C. Coss, Alice S. Mims, Lai Tzung-Huei, Shelley Orwick, Steven Sher, Katie Williams, Lindsey T. Brinton, Pu Zhang
Combined treatment of AR-42 and KPT-9274 leads to mitochondrial potential collapses in cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5554421cc4609792f5f692e7786cafe
https://doi.org/10.1158/1078-0432.22484252
https://doi.org/10.1158/1078-0432.22484252
Autor:
Samuel K. Kulp, Nicole Grieselhuber, James S. Blachly, Tierney Kauffman, Deepa Sampath, Hannah Phillips, Matthew Cannon, Lapo Alinari, Youssef Youssef, Pearlly S. Yan, Katie Williams, Larry Beaver, Lai Tzung-Huei, Steven Sher, Allison M. Mustonen, Christopher C. Coss, Alice S. Mims, John C. Byrd, Shelley Orwick, Lindsey T. Brinton, Daniel Canfield, Pu Zhang, Shaneice Mitchell, Amy Lehman, Wing Keung Chan, Rosa Lapalombella
Publikováno v:
Clin Cancer Res
Purpose: Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors (NAMPTi) are currently in development, but may be limited as single-agent therapy due to compound-specific toxicity and cancer metabolic plasticity allowing resistance development. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec1af423ac5274bfd7de47fb1101bd1c
https://europepmc.org/articles/PMC8054771/
https://europepmc.org/articles/PMC8054771/
Autor:
Tzyy-Jye Doong, Nicole Grieselhuber, Nyla A. Heerema, Gerard Lozanski, Cecelia R. Miller, Karilyn Larkin, Tierney Kauffman, Rosa Lapalombella, Arletta Lozanski, John C. Byrd, Clara D. Bloomfield, Casey Cempre, Shelley Orwick, Bhavana Bhatnagar, Alice S. Mims, Lynne V. Abruzzo, Gregory K. Behbehani, Eileen Hu, Virginia M. Goettl, Alison Walker, Steven Sher, Pu Zhang, Caner Saygin, Jordan N. Skinner, James S. Blachly, Jadwiga Labanowska, Deedra Nicolet
Publikováno v:
Leukemia
Hematopoiesis is hierarchical, and it has been postulated that acute myeloid leukemia (AML) is organized similarly with leukemia stem cells (LSCs) residing at the apex. Limited cells acquired by fluorescence activated cell sorting in tandem with targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a7eae162980dfd0939ef606772acafd
https://pubmed.ncbi.nlm.nih.gov/34480107
https://pubmed.ncbi.nlm.nih.gov/34480107
