Gene Delivery of TGF-β3 and BMP2 in an MSC-Laden Alginate Hydrogel for Articular Cartilage and Endochondral Bone Tissue Engineering.

Autor: Gonzalez-Fernandez T; 1 Trinity Centre for Bioengineering (TCBE), Trinity Biomedical Sciences Institute , Trinity College Dublin, Dublin, Ireland .; 2 Department of Mechanical and Manufacturing Engineering, School of Engineering, Trinity College Dublin , Dublin, Ireland .; 3 Advanced Materials and Bioengineering Research Centre (AMBER), Royal College of Surgeons in Ireland and Trinity College Dublin , Dublin, Ireland .; 4 Tissue Engineering Research Group (TERG), Department of Anatomy, Royal College of Surgeons in Ireland , Dublin, Ireland ., Tierney EG; 4 Tissue Engineering Research Group (TERG), Department of Anatomy, Royal College of Surgeons in Ireland , Dublin, Ireland ., Cunniffe GM; 1 Trinity Centre for Bioengineering (TCBE), Trinity Biomedical Sciences Institute , Trinity College Dublin, Dublin, Ireland .; 2 Department of Mechanical and Manufacturing Engineering, School of Engineering, Trinity College Dublin , Dublin, Ireland .; 3 Advanced Materials and Bioengineering Research Centre (AMBER), Royal College of Surgeons in Ireland and Trinity College Dublin , Dublin, Ireland ., O'Brien FJ; 1 Trinity Centre for Bioengineering (TCBE), Trinity Biomedical Sciences Institute , Trinity College Dublin, Dublin, Ireland .; 3 Advanced Materials and Bioengineering Research Centre (AMBER), Royal College of Surgeons in Ireland and Trinity College Dublin , Dublin, Ireland .; 4 Tissue Engineering Research Group (TERG), Department of Anatomy, Royal College of Surgeons in Ireland , Dublin, Ireland ., Kelly DJ; 1 Trinity Centre for Bioengineering (TCBE), Trinity Biomedical Sciences Institute , Trinity College Dublin, Dublin, Ireland .; 2 Department of Mechanical and Manufacturing Engineering, School of Engineering, Trinity College Dublin , Dublin, Ireland .; 3 Advanced Materials and Bioengineering Research Centre (AMBER), Royal College of Surgeons in Ireland and Trinity College Dublin , Dublin, Ireland .; 4 Tissue Engineering Research Group (TERG), Department of Anatomy, Royal College of Surgeons in Ireland , Dublin, Ireland .

Publikováno v: Tissue engineering. Part A [Tissue Eng Part A] 2016 May; Vol. 22 (9-10), pp. 776-87.

Development of a gene-activated scaffold platform for tissue engineering applications using chitosan-pDNA nanoparticles on collagen-based scaffolds.

Autor: Raftery RM; Tissue Engineering Research Group, Dept. of Anatomy, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Dublin, Ireland; Trinity Centre for Bioengineering, Trinity College Dublin, Dublin 2, Dublin, Ireland; Advanced Materials and Bioengineering Research Centre (AMBER), RCSI and TCD, Dublin, Ireland., Tierney EG; Tissue Engineering Research Group, Dept. of Anatomy, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Dublin, Ireland; Trinity Centre for Bioengineering, Trinity College Dublin, Dublin 2, Dublin, Ireland; Advanced Materials and Bioengineering Research Centre (AMBER), RCSI and TCD, Dublin, Ireland., Curtin CM; Tissue Engineering Research Group, Dept. of Anatomy, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Dublin, Ireland; Trinity Centre for Bioengineering, Trinity College Dublin, Dublin 2, Dublin, Ireland; Advanced Materials and Bioengineering Research Centre (AMBER), RCSI and TCD, Dublin, Ireland., Cryan SA; Tissue Engineering Research Group, Dept. of Anatomy, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Dublin, Ireland; Trinity Centre for Bioengineering, Trinity College Dublin, Dublin 2, Dublin, Ireland; School of Pharmacy, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Dublin, Ireland., O'Brien FJ; Tissue Engineering Research Group, Dept. of Anatomy, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Dublin, Ireland; Trinity Centre for Bioengineering, Trinity College Dublin, Dublin 2, Dublin, Ireland; Advanced Materials and Bioengineering Research Centre (AMBER), RCSI and TCD, Dublin, Ireland. Electronic address: fjobrien@rcsi.ie.

Publikováno v: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2015 Jul 28; Vol. 210, pp. 84-94. Date of Electronic Publication: 2015 May 15.

High levels of ephrinB2 over-expression increases the osteogenic differentiation of human mesenchymal stem cells and promotes enhanced cell mediated mineralisation in a polyethyleneimine-ephrinB2 gene-activated matrix.

Autor: Tierney EG; Tissue Engineering Research Group, Department of Anatomy, Royal College of Surgeons in Ireland, Dublin, Ireland., McSorley K, Hastings CL, Cryan SA, O'Brien T, Murphy MJ, Barry FP, O'Brien FJ, Duffy GP

Publikováno v: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2013 Feb 10; Vol. 165 (3), pp. 173-82. Date of Electronic Publication: 2012 Nov 29.

The development of non-viral gene-activated matrices for bone regeneration using polyethyleneimine (PEI) and collagen-based scaffolds.

Autor: Tierney EG; Department of Anatomy, Royal College of Surgeons in Ireland, Dublin, Ireland., Duffy GP, Hibbitts AJ, Cryan SA, O'Brien FJ

Publikováno v: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2012 Mar 10; Vol. 158 (2), pp. 304-11. Date of Electronic Publication: 2011 Nov 27.