Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Tiernan T. O'Malley"'
Autor:
Ming Jin, Brian O’Nuallain, Wei Hong, Justin Boyd, Valentina N. Lagomarsino, Tiernan T. O’Malley, Wen Liu, Charles R. Vanderburg, Matthew P. Frosch, Tracy Young-Pearse, Dennis J. Selkoe, Dominic M. Walsh
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
The optimal Aβ species to target for the potential treatment of Alzheimer’s disease has not yet been established. Here, the authors describe an in vitro assay that uses extracts from brain tissue from patients with Alzheimer’s disease, and appli
Externí odkaz:
https://doaj.org/article/1b248bb1ced34f1e829628bfcb182dd4
Autor:
Ming Lei, Huixin Xu, Zhangyuan Li, Zemin Wang, Tiernan T. O'Malley, Dainan Zhang, Dominic M. Walsh, Pingyi Xu, Dennis J. Selkoe, Shaomin Li
Publikováno v:
Neurobiology of Disease, Vol 85, Iss , Pp 111-121 (2016)
Epileptic activity may be more prevalent in early stage Alzheimer's disease (AD) than previously believed. Several studies report spontaneous seizures and interictal discharges in mouse models of AD undergoing age-related Aβ accumulation. The mechan
Externí odkaz:
https://doaj.org/article/f0335e4fcad6439e8aee2320f0547106
Autor:
Nicole D. Bartolo, Niall Mortimer, Mariah A. Manter, Nicholas Sanchez, Misha Riley, Tiernan T. O’Malley, Jacob M. Hooker
Publikováno v:
ACS Chemical Neuroscience. 13:3641-3660
Activation of microglial cells accompanies the progression of many neurodegenerative disorders, including Alzheimer's disease (AD). Development of molecular imaging tools specific to microglia can help elucidate the mechanism through which microglia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11ffaad589f2d165d147e9fcb4819301
https://doi.org/10.1021/acschemneuro.2c00607
https://doi.org/10.1021/acschemneuro.2c00607
Autor:
Catherine K. Xu, Sean R. A. Devenish, Fang Qian, Samuel I. A. Cohen, Oskar Hansson, Thierry Bussiere, Georg Meisl, Sara Linse, Tiernan T. O'Malley, Katja Bernfur, Tuomas P. J. Knowles, Michele Vendruscolo, Eimantas Sileikis, Paul H. Weinreb, Tom Scheidt, Christopher M. Dobson, Martin Lundqvist
Publikováno v:
Nature Structural & Molecular Biology. 27:1125-1133
The amyloid cascade hypothesis, according to which the self-assembly of amyloid-β peptide (Aβ) is a causative process in Alzheimer’s disease, has driven many therapeutic efforts for the past 20 years. Failures of clinical trials investigating Aβ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::509d989428265cfa7f1a5b5d14c0adf4
https://doi.org/10.1038/s41594-020-0505-6
https://doi.org/10.1038/s41594-020-0505-6
Autor:
Monichan Phay, Alfred T Welzel, Angela D Williams, Helen P McWilliams-Koeppen, Veronika Blinder, Tiernan T O'Malley, Alan Solomon, Dominic M Walsh, Brian O'Nuallain
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137344 (2015)
Amyloid-reactive IgGs isolated from pooled blood of normal individuals (pAbs) have demonstrated clinical utility for amyloid diseases by in vivo targeting and clearing amyloidogenic proteins and peptides. We now report the following three novel findi
Externí odkaz:
https://doaj.org/article/d9c973e149054991ba50bef3823c4302
Autor:
Sara Linse, Christopher M. Dobson, Tiernan T. O'Malley, Eimantas Sileikis, Paul H. Weinreb, Tom Scheidt, Katja Bernfur, Michele Vendruscolo, Sean R. A. Devenish, Tuomas P. J. Knowles, Catherine K. Xu, Georg Meisl, Thierry Bussiere, Oskar Hansson, Samuel Cohen, Martin Lundquist, Fang Qian
Alzheimer9s disease affects nearly 50 million people worldwide with an overall cost corresponding to more than 1% of the global economy. The amyloid cascade hypothesis, according to which the misfolding and self-assembly of the amyloid-β peptide (A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f5c7e7c45196a97662812ce573a11e7
Autor:
Dennis J. Selkoe, Matthew P. Frosch, Zemin Wang, Xin Sun, Kaj Blennow, Wei Hong, Wen Liu, Dominic M. Walsh, Erik Portelius, Henrik Zetterberg, Gunnar Brinkmalm, Tiernan T. O'Malley
Publikováno v:
Brain
The primary structure of canonical amyloid-β-protein was elucidated more than 30 years ago, yet the forms of amyloid-β that play a role in Alzheimer's disease pathogenesis remain poorly defined. Studies of Alzheimer's disease brain extracts suggest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a8587b7d2da9b12db88839058560015
https://europepmc.org/articles/PMC6487330/
https://europepmc.org/articles/PMC6487330/
Publikováno v:
Biochemistry. 55:6150-6161
Extracts of Alzheimer’s disease (AD) brain that contain what appear to be sodium dodecyl sulfate-stable amyloid β-protein (Aβ) dimers potently block LTP and impair memory consolidation. Brain-derived dimers can be physically separated the Aβ mon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05ae474b1679e59c7f0fbcab95bab695
https://doi.org/10.1021/acs.biochem.6b00453
https://doi.org/10.1021/acs.biochem.6b00453
Autor:
Tiernan T. O'Malley, Zhangyuan Li, Ming Lei, Shaomin Li, Huixin Xu, Dennis J. Selkoe, Pingyi Xu, Dainan Zhang, Zemin Wang, Dominic M. Walsh
Publikováno v:
Neurobiology of Disease, Vol 85, Iss, Pp 111-121 (2016)
Epileptic activity may be more prevalent in early stage Alzheimer’s disease (AD) than previously believed. Several studies report spontaneous seizures and interictal discharges in mouse models of AD undergoing age-related Aβ accumulation. The mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af0dba8dddb06581f625af90fbeaa355
https://doi.org/10.1016/j.nbd.2015.10.019
https://doi.org/10.1016/j.nbd.2015.10.019
Autor:
Christian Haass, Wen Liu, Ming Jin, Michael Willem, Matthew P. Frosch, Wei Hong, Zemin Wang, Dominic M. Walsh, Tiernan T. O'Malley
Publikováno v:
Acta neuropathologica 136(1), 19-40 (2018). doi:10.1007/s00401-018-1846-7
Significant data suggest that soluble Aβ oligomers play an important role in Alzheimer’s disease (AD), but there is great confusion over what exactly constitutes an Aβ oligomer and which oligomers are toxic. Most studies have utilized synthetic A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9e1ff90cdc49e8ad480827ef197e1ad
https://pubmed.ncbi.nlm.nih.gov/29687257
https://pubmed.ncbi.nlm.nih.gov/29687257