Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Tieno Germann"'
Autor:
Sven Frormann, B.Y. Kögel, Bernd Sundermann, Klaus Linz, Achim Kless, Helmut Sonnenschein, Wolfgang P. Schröder, Stefan Schunk, Werner Englberger, Derek Saunders, Hans Schick, Tieno Germann, Saskia Zemolka, Thomas Christoph, Claudia Hinze, Stefan Oberbörsch, Stephanie Harlfinger
Publikováno v:
ACS Medicinal Chemistry Letters. 5:857-862
In a previous communication, our efforts leading from 1 to the identification of spiro[cyclohexane-dihydropyrano[3,4-b]indole]-amine 2a as analgesic NOP and opioid receptor agonist were disclosed and their favorable in vitro and in vivo pharmacologic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38fbb1f07a0eb7a8eeee56a55aa18175
https://doi.org/10.1021/ml500117c
https://doi.org/10.1021/ml500117c
Autor:
Tieno Germann, Bernd Sundermann, Sven Frormann, Helmut Sonnenschein, Hans Schick, Werner Englberger, B.Y. Kögel, Derek Saunders, Achim Kless, Klaus Linz, Stefan Oberbörsch, Stephanie Harlfinger, Saskia Zemolka, Thomas Christoph, Claudia Hinze, Wolfgang P. Schröder, Stefan Schunk
Publikováno v:
ACS Medicinal Chemistry Letters. 5:851-856
We report the discovery of spiro[cyclohexane-pyrano[3,4-b]indole]-amines, as functional nociceptin/orphanin FQ peptide (NOP) and opioid receptor agonists with strong efficacy in preclinical models of acute and neuropathic pain. Utilizing 4-(dimethyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5fe90b0366ab101fe23bc576f011c77
https://doi.org/10.1021/ml500116x
https://doi.org/10.1021/ml500116x
Autor:
Thomas Fiebig, Markus Hecker, Tieno Germann, Bianca Lienenlüke, Tomislav Stojanovic, A Fayyazi
Publikováno v:
British Journal of Pharmacology. 133:1414-1423
1. Immune response-modulating drugs such as thalidomide may be of therapeutic value in the treatment of chronic inflammatory bowel diseases including Crohn's disease (CD). In the present study, we have investigated whether thalidomide exerts this eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::466330b9e6f6938c950b2fb8cd1c36b9
https://doi.org/10.1038/sj.bjp.0704193
https://doi.org/10.1038/sj.bjp.0704193
Publikováno v:
European Journal of Immunology. 30:2864-2870
The interaction of proinflammatory type 1 T helper (Th1) cells expressing the CD40 ligand (CD154) with endothelial cells expressing the corresponding receptor (CD40) may play an important role in chronic inflammation including arteriosclerosis. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e993cd30631010e3093d9f4eeefe6dc9
https://doi.org/10.1002/1521-4141(200010)30:10<2864::aid-immu2864>3.0.co
https://doi.org/10.1002/1521-4141(200010)30:10<2864::aid-immu2864>3.0.co
Publikováno v:
Graefe's Archive for Clinical and Experimental Ophthalmology. 237:952-961
Neovascular diseases are the leading causes of blindness in humans. Although several promissing compounds have been isolated, pharmacological treatment remains difficult. Thalidomide has inhibitory effects on angiogenesis in the corneal micropocket a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5a31663c51891fc2954aa9a17a39ba8
https://doi.org/10.1007/s004170050330
https://doi.org/10.1007/s004170050330
Autor:
Jörg F. Schlaak, Christoph Becker, K H Meyer zum Büschenfelde, Kai Hildner, Edgar Schmitt, Elisabeth Märker-Hermann, Tieno Germann, Markus F. Neurath
Publikováno v:
Annals of the New York Academy of Sciences. 859:204-207
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7f2e3828eaf975c8e983dccba565cad
https://doi.org/10.1111/j.1749-6632.1998.tb11129.x
https://doi.org/10.1111/j.1749-6632.1998.tb11129.x
Autor:
Marzena Więckowska, Barbara Różalska, Wiesława Rudnicka, Tieno Germann, Jacek Szeliga, Małgorzata Kaczmarek
Publikováno v:
Microbiology and Immunology. 41:847-853
Several genes involved in the determination of Listeria monocytogenes pathogenesis have been identified. Among them, plcA gene encodes phosphatidylinositol-specific phospholipase C (PI-PLC), plcB gene encodes a broad-range phospholipase C (PC-PLC), a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::741a5b29d8485ff304bf2148fd36fd34
https://doi.org/10.1111/j.1348-0421.1997.tb01939.x
https://doi.org/10.1111/j.1348-0421.1997.tb01939.x
Autor:
Petra Hoehn, Erwin Rüde, Sigrid Goedert, Stephan Roelsch, Edgar Schmitt, Tieno Germann, Norbert Palm
Publikováno v:
Immunobiology. 196:475-484
Cytokines were found to play a key role in Th cell differentiation. Among them IL-12 was shown to be a potent differentiation factor for Th1 cells, whereas IL-4 is the only known cytokine that promotes the development of Th2 cells. Upon addition of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f5ead0f1d482710face39571688d38d
https://doi.org/10.1016/s0171-2985(97)80064-2
https://doi.org/10.1016/s0171-2985(97)80064-2
Publikováno v:
Annals of the New York Academy of Sciences. 795:227-240
A destructive joint disease can be induced in susceptible DBA/1 mice by immunization with type II collagen emulsified with oil and either killed Mycobacterium tuberculosis or IL-12 as adjuvant. Cellular and humoral anti-collagen immune mechanisms app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2812b7674e13599a5370115187acd393
https://doi.org/10.1111/j.1749-6632.1996.tb52672.x
https://doi.org/10.1111/j.1749-6632.1996.tb52672.x
Publikováno v:
International Immunology. 8:1221-1227
DBA/1 (H-2q) and C57BL/6 (H-2b) mice develop an intermediate immune responses when immunized with chicken type II collagen (CII) emulsified with incomplete Freund's adjuvant (IFA). Only a few animals develop a mild form of arthritis. As reported befo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db2519c8fed506c61fefa4cf89287da0
https://doi.org/10.1093/intimm/8.8.1221
https://doi.org/10.1093/intimm/8.8.1221