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pro vyhledávání: '"Tienju Wang"'
Autor:
Jing Tian, Kun Jia, Tienju Wang, Lan Guo, Zhenyu Xuan, Elias K. Michaelis, Russell H. Swerdlow, Alzheimer’s Disease Neuroimaging Initiative, Heng Du
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract The etiopathogenesis of late-onset Alzheimer’s disease (AD) is increasingly recognized as the result of the combination of the aging process, toxic proteins, brain dysmetabolism, and genetic risks. Although the role of mitochondrial dysfun
Externí odkaz:
https://doaj.org/article/a34bda56f50e4eb085e3cf1b8b00de17
Publikováno v:
JCI Insight, Vol 8, Iss 22 (2023)
Mitochondria are critical for neurophysiology, and mitochondrial dysfunction constitutes a characteristic pathology in both brain aging and Alzheimer disease (AD). Whether mitochondrial deficiency in brain aging and AD is mechanistically linked, howe
Externí odkaz:
https://doaj.org/article/1f5c1d7ba363421aa5d4a37986a21b89
Publikováno v:
JCI Insight, Vol 8, Iss 10 (2023)
Elderly individuals frequently report cognitive decline, while various studies indicate hippocampal functional declines with advancing age. Hippocampal function is influenced by ghrelin through hippocampus-expressed growth hormone secretagogue recept
Externí odkaz:
https://doaj.org/article/fa9cb19b661c414eb4c9356da3074383
Publikováno v:
Journal of Alzheimer's Disease. 93:605-619
Background: Deprivation of extracellular serotonin has been linked to cognitive decline and neuropsychiatric disturbances in Alzheimer’s disease (AD). However, despite degeneration of serotonin-producing neurons, whether serotonin release is affect
Publikováno v:
J Alzheimers Dis
Background: Metabolic dysfunction links to cognitive deficits in Alzheimer’s disease (AD). Leptin is an anti-obesity hormone that modulates energy homeostasis and memory function. Although leptin deregulation is implicated in mouse models of AD-lik
Publikováno v:
Current Opinion in Neurobiology. 78:102655
Alzheimer's disease (AD) is the most common type of dementia in seniors. Current efforts to understand the etiopathogenesis of this neurodegenerative disorder have brought forth questions about systemic factors in the development of AD. Ghrelin is a
Publikováno v:
Journal of Alzheimer's disease : JAD. 72(2)
Hippocampal lesions including synaptic injury, neuroinflammation, and impaired neurogenesis are featured pathology closely associated with neuronal stress and cognitive impairment in Alzheimer's disease (AD). Previous studies suggest that ghrelin and