Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Tien-Ying Hsiang"'
Autor:
Michalina A. Montaño, Meagan J. Bemer, Kate B. Heller, Allison Meisner, Zarna Marfatia, Elena A. Rechkina, Leah R. Padgett, Charlotte L. Ahls, Douglas Rains, Linhui Hao, Tien-Ying Hsiang, Gerard A. Cangelosi, Alexander L. Greninger, Jason L. Cantera, Allison Golden, Roger B. Peck, David S. Boyle, Michael Gale, Jr, Paul K. Drain
Publikováno v:
International Journal of Infectious Diseases, Vol 117, Iss , Pp 287-294 (2022)
Objectives: This study assesses and compares the performance of different swab types and specimen collection sites for SARS-CoV-2 testing, to reference standard real-time reverse transcriptase-polymerase chain reaction (RT-PCR) and viral culture. Met
Externí odkaz:
https://doaj.org/article/eff16240d3474357915a98a71b334683
Autor:
Pavan K. Bhatraju, MD, MSc, Eric D. Morrell, MD, Ian B. Stanaway, PhD, Neha A. Sathe, MD, MSc, Avantika Srivastava, MS, Radu Postelnicu, MD, Richard Green, BS, Adair Andrews, BSN, Martin Gonzalez, BS, Christopher J. Kratochvil, MD, Vishakha K. Kumar, BS, Tien-Ying Hsiang, PhD, Michael Gale, Jr, PhD, George L. Anesi, MD, David Wyles, MD, M. Jana Broadhurst, MD, PhD, David Brett-Major, MD, MPH, Vikramjit Mukherjee, MD, Jonathan E. Sevransky, MD, Douglas Landsittel, PhD, Chi Hung, MD, William A. Altemeier, MD, Sina A. Gharib, MD, Timothy M. Uyeki, MD, MPH, J. Perren Cobb, MD, Janice M. Liebler, MD, David R. Crosslin, PhD, Gail P. Jarvik, MD, Leopoldo N. Segal, MD, Laura Evans, MD, Carmen Mikacenic, MD, Mark M. Wurfel, MD, PhD
Publikováno v:
Critical Care Explorations, Vol 5, Iss 1, p e0827 (2023)
IMPORTANCE:. Vascular dysfunction and capillary leak are common in critically ill COVID-19 patients, but identification of endothelial pathways involved in COVID-19 pathogenesis has been limited. Angiopoietin-like 4 (ANGPTL4) is a protein secreted in
Externí odkaz:
https://doaj.org/article/de84ce123a564b7b9fa872a7b541c824
Autor:
Jessica Wagoner, Shawn Herring, Tien-Ying Hsiang, Aleksandr Ianevski, Scott B. Biering, Shuang Xu, Markus Hoffmann, Stefan Pöhlmann, Michael Gale, Tero Aittokallio, Joshua T. Schiffer, Judith M. White, Stephen J. Polyak
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 5 (2022)
ABSTRACT Three directly acting antivirals (DAAs) demonstrated substantial reduction in COVID-19 hospitalizations and deaths in clinical trials. However, these agents did not completely prevent severe illness and are associated with cases of rebound i
Externí odkaz:
https://doaj.org/article/9c609e33ab9f488ab9c4badf3f7caa97
Autor:
David W. Hawman, Kimberly Meade-White, Chad Clancy, Jacob Archer, Troy Hinkley, Shanna S. Leventhal, Deepashri Rao, Allie Stamper, Matthew Lewis, Rebecca Rosenke, Kyle Krieger, Samantha Randall, Amit P. Khandhar, Linhue Hao, Tien-Ying Hsiang, Alexander L. Greninger, Michael Gale, Jr, Peter Berglund, Deborah Heydenburg Fuller, Kyle Rosenke, Heinz Feldmann, Jesse H. Erasmus
Publikováno v:
EBioMedicine, Vol 83, Iss , Pp 104196- (2022)
Summary: Background: In late 2021, the SARS-CoV-2 Omicron (B.1.1.529) variant of concern (VoC) was reported with many mutations in the viral spike protein that were predicted to enhance transmissibility and allow viral escape of neutralizing antibodi
Externí odkaz:
https://doaj.org/article/ab324282f355407caf9cfe9a89fda64c
Autor:
Rebecca Elyanow, Thomas M. Snyder, Sudeb C. Dalai, Rachel M. Gittelman, Jim Boonyaratanakornkit, Anna Wald, Stacy Selke, Mark H. Wener, Chihiro Morishima, Alexander L. Greninger, Michael Gale Jr., Tien-Ying Hsiang, Lichen Jing, Michael R. Holbrook, Ian M. Kaplan, H. Jabran Zahid, Damon H. May, Jonathan M. Carlson, Lance Baldo, Thomas Manley, Harlan S. Robins, David M. Koelle
Publikováno v:
JCI Insight, Vol 7, Iss 10 (2022)
BACKGROUND Measuring the immune response to SARS-CoV-2 enables assessment of past infection and protective immunity. SARS-CoV-2 infection induces humoral and T cell responses, but these responses vary with disease severity and individual characterist
Externí odkaz:
https://doaj.org/article/c720e1a7f2ea4a9bb6e8db6d06e7b8ab
Autor:
Lichen Jing, Xia Wu, Maxwell P. Krist, Tien-Ying Hsiang, Victoria L. Campbell, Christopher L. McClurkan, Sydney M. Favors, Lawrence A. Hemingway, Charmie Godornes, Denise Q. Tong, Stacy Selke, Angela C. LeClair, Chu-Woo Pyo, Daniel E. Geraghty, Kerry J. Laing, Anna Wald, Michael Gale Jr., David M. Koelle
Publikováno v:
JCI Insight, Vol 7, Iss 6 (2022)
SARS-CoV-2 provokes a robust T cell response. Peptide-based studies exclude antigen processing and presentation biology, which may influence T cell detection studies. To focus on responses to whole virus and complex antigens, we used intact SARS-CoV-
Externí odkaz:
https://doaj.org/article/ac5bab028d2c47d8a3ac6df92bba3c0e
Autor:
Linhui Hao, Tien-Ying Hsiang, Ronit R. Dalmat, Renee Ireton, Jennifer F. Morton, Caleb Stokes, Jason Netland, Malika Hale, Chris Thouvenel, Anna Wald, Nicholas M. Franko, Kristen Huden, Helen Y. Chu, Alex Sigal, Alex L. Greninger, Sasha Tilles, Lynn K. Barrett, Wesley C. Van Voorhis, Jennifer Munt, Trevor Scobey, Ralph S. Baric, David J. Rawlings, Marion Pepper, Paul K. Drain, Michael Gale
Publikováno v:
Viruses, Vol 15, Iss 2, p 530 (2023)
New variants of SARS-CoV-2 continue to emerge and evade immunity. We isolated SARS-CoV-2 temporally across the pandemic starting with the first emergence of the virus in the western hemisphere and evaluated the immune escape among variants. A clinic-
Externí odkaz:
https://doaj.org/article/fdaa1f3636174da08d27e757b88a435b
Autor:
Michael A. Davis, Kathleen Voss, J. Bryan Turnbull, Andrew T. Gustin, Megan Knoll, Antonio Muruato, Tien-Ying Hsiang, Kenneth H. Dinnon III, Sarah R. Leist, Katie Nickel, Ralph S. Baric, Warren Ladiges, Shreeram Akilesh, Kelly D. Smith, Michael Gale
Publikováno v:
Vaccines, Vol 11, Iss 1, p 47 (2022)
We present a comprehensive analysis of SARS-CoV-2 infection and recovery using wild type C57BL/6 mice and a mouse-adapted virus, and we demonstrate that this is an ideal model of infection and recovery that phenocopies acute human disease arising fro
Externí odkaz:
https://doaj.org/article/60f098023b5a49cb8e78a28adaf66d49
Autor:
David W Hawman, Kimberly Meade-White, Jacob Archer, Shanna S Leventhal, Drew Wilson, Carl Shaia, Samantha Randall, Amit P Khandhar, Kyle Krieger, Tien-Ying Hsiang, Michael Gale, Peter Berglund, Deborah Heydenburg Fuller, Heinz Feldmann, Jesse H Erasmus
Publikováno v:
eLife, Vol 11 (2022)
Despite mass public health efforts, the SARS-CoV2 pandemic continues as of late 2021 with resurgent case numbers in many parts of the world. The emergence of SARS-CoV2 variants of concern (VoCs) and evidence that existing vaccines that were designed
Externí odkaz:
https://doaj.org/article/90febf2692524714945d906eb9c6e393
Autor:
Louisa Helms, Silvia Marchiano, Ian B. Stanaway, Tien-Ying Hsiang, Benjamin A. Juliar, Shally Saini, Yan Ting Zhao, Akshita Khanna, Rajasree Menon, Fadhl Alakwaa, Carmen Mikacenic, Eric D. Morrell, Mark M. Wurfel, Matthias Kretzler, Jennifer L. Harder, Charles E. Murry, Jonathan Himmelfarb, Hannele Ruohola-Baker, Pavan K. Bhatraju, Michael Gale Jr., Benjamin S. Freedman
Publikováno v:
JCI Insight, Vol 6, Iss 24 (2021)
Kidneys are critical target organs of COVID-19, but susceptibility and responses to infection remain poorly understood. Here, we combine SARS-CoV-2 variants with genome-edited kidney organoids and clinical data to investigate tropism, mechanism, and
Externí odkaz:
https://doaj.org/article/f1245ff7051b4c249e2410817e4f3c9e