Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Tien-Hao Chen"'
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract In vitro transcribed synthetic messenger RNAs (mRNAs) represent a novel therapeutic modality. To overcome the inherent immunogenicity, as well as to increase the therapeutic efficacy of the molecules, uridine analogs—such as pseudouridine
Externí odkaz:
https://doaj.org/article/65a9a07ab5bd430ea32d4d06c21d3b6f
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
The SARS-CoV-2 viral genome contains a positive-strand single-stranded RNA of ∼30 kb. Human ACE2 protein is the receptor for SARS-CoV-2 virus attachment and infection. We propose to use ribonucleases (RNases) as antiviral agents to destroy the vira
Externí odkaz:
https://doaj.org/article/a49ee93ac12144d0b2b782c712df862c
Autor:
Guanzhong Mao, Tien-Hao Chen, Abhishek S Srivastava, David Kosek, Pradip K Biswas, Venkat Gopalan, Leif A Kirsebom
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0160246 (2016)
Two broad classes of RNase P trim the 5' leader of precursor tRNAs (pre-tRNAs): ribonucleoprotein (RNP)- and proteinaceous (PRORP)-variants. These two RNase P types, which use different scaffolds for catalysis, reflect independent evolutionary paths.
Externí odkaz:
https://doaj.org/article/577ba2b556aa4e0b8f1688bd8c81611f
Publikováno v:
Scientific Reports. 12
In vitro transcribed synthetic messenger RNAs (mRNAs) represent a novel therapeutic modality. To overcome the inherent immunogenicity, as well as to increase the therapeutic efficacy of the molecules, uridine analogs—such as pseudouridine (Ψ) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98a2b1b1310a3d2b714f90b4af75c592
https://doi.org/10.1038/s41598-022-17249-1
https://doi.org/10.1038/s41598-022-17249-1
Autor:
Eric J Wolf, Sebastian Grünberg, Nan Dai, Tien-Hao Chen, Bijoyita Roy, Erbay Yigit, Ivan R Corrêa
Publikováno v:
Nucleic acids research. 50(18)
With the rapid growth of synthetic messenger RNA (mRNA)-based therapeutics and vaccines, the development of analytical tools for characterization of long, complex RNAs has become essential. Tandem liquid chromatography–mass spectrometry (LC–MS/MS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfb8bda30f7e549689072ad818f356a8
https://pubmed.ncbi.nlm.nih.gov/35871301
https://pubmed.ncbi.nlm.nih.gov/35871301
Publikováno v:
Scientific reports. 12(1)
In vitro transcribed synthetic messenger RNAs (mRNAs) represent a novel therapeutic modality. To overcome the inherent immunogenicity, as well as to increase the therapeutic efficacy of the molecules, uridine analogs-such as pseudouridine (Ψ) and N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dcea1cb9cf11df75bb522caeae5f0014
https://pubmed.ncbi.nlm.nih.gov/35906281
https://pubmed.ncbi.nlm.nih.gov/35906281
Autor:
Sebastian Grünberg, Erbay Yigit, Tien-Hao Chen, Nan Dai, Baptiste Coxam, Nicole M. Nichols, Ivan R. Corrêa, Lana Saleh
Publikováno v:
Nucleic Acids Research
Since its initial characterization, Escherichia coli RNase I has been described as a single-strand specific RNA endonuclease that cleaves its substrate in a largely sequence independent manner. Here, we describe a strong calcium (Ca2+)-dependent acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6c9d6b8368d9f336e973fab8ede7570
https://doi.org/10.1093/nar/gkab284
https://doi.org/10.1093/nar/gkab284
Publikováno v:
Nucleic Acids Research. 51:e36-e36
T7 RNA polymerase is commonly used to synthesize large quantities of RNA for a wide variety of applications, from basic science to mRNA therapeutics. This in vitro system, while showing high fidelity in many ways, is also well known for producing lon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b934eb78d27e2e189af66aec0e02172
https://doi.org/10.1093/nar/gkad027
https://doi.org/10.1093/nar/gkad027
Publikováno v:
The Journal of Biological Chemistry
Journal of Biological Chemistry
Journal of Biological Chemistry
Recent studies have indicated that tau, a protein involved in Alzheimer's disease and other neurodegenerative disorders, has a propensity to undergo liquid–liquid phase separation (LLPS). However, the mechanism of this process remains unknown. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0360627ee0af02266451c81e87e7e2a8
http://europepmc.org/articles/PMC6643045
http://europepmc.org/articles/PMC6643045
Publikováno v:
Journal of Molecular Biology. 431:615-624
RNase P catalyzes removal of the 5′ leader from precursor tRNAs (pre-tRNAs) in all three domains of life. Some eukaryotic cells contain multiple forms of the protein-only RNase P (PRORP) variant, prompting efforts to unravel this seeming redundancy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b42aae4da6e7abf0c66d946c7f1215e7
https://doi.org/10.1016/j.jmb.2018.11.004
https://doi.org/10.1016/j.jmb.2018.11.004