Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Tien T. Duong"'
Publikováno v:
Journal of the Chemical Society. Chemical communications. 1992(22)
Boron enolates obtained from optically active oxazolidinone derivative of cis-1-amino-2-hydroxyindan are reacted with various aldehydes to provide highly enantioselective aldol products in good yields.
Autor:
Min Teng, Roshantha A.S. Chandraratna, Elliott S. Klein, Tien T. Duong, Andrew M. Standevan, Richard L. Beard
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:3145-3148
Retinoids are analogues of all- trans -retinoic acid, a powerful hormone that mediates many fundamental biological processes. Cancer and other serious hyperproliferative diseases are attractive therapeutic targets for retinoids, but the therapeutic u
Autor:
Roshantha A.S. Chandraratna, Richard L. Beard, Diana F. Colon, Scott M. Thacher, Taghreed Arefieg, Tien T. Duong, Min Teng
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2373-2378
Retinoids are natural and synthetic analogs of the hormone retinoic acid. Retinoids are currently being investigated clinically as drugs in several areas, including dermatology and oncology. We report the synthesis and biological activity of a new se
Publikováno v:
Journal of Medicinal Chemistry. 39:3035-3038
Autor:
Arun K. Ghosh, Wayne J. Thompson, M. Katharine Holloway, Sean P. McKee, Tien T. Duong, Hee Yoon Lee, Peter M. Munson, Anthony M. Smith, Jenny M. Wai, Paul L. Darke, Joan A. Zugay, Emilio A. Emini, William A. Schleif, Joel R. Huff, Paul S. Anderson
Publikováno v:
Journal of Medicinal Chemistry. 36:2300-2310
A series of protease inhibitors bearing constrained unnatural amino acids at the P2-position and novel heterocycles at the P3-position of compound 1 (Ro 31-8959) were synthesized, and their in vitro enzyme inhibitory and antiviral activities were eva
Publikováno v:
ChemInform. 22
A series of substituted 2-allyl-1,1-dimethylisoureas (allyl N,N-dimethylcarbamimidates) was prepared by the reaction of the corresponding allylic alcohols with dimethylcyanamide in the presence of sodium hydride. Treatment of the isoureas with mercur
Autor:
Taghreed Arefieg, Tien T. Duong, Min Teng, Roshantha A.S. Chandraratna, Diana F. Colon, Scott M. Thacher, Richard L. Beard
Publikováno v:
ChemInform. 29
Publikováno v:
Synthesis. 1991:86-90
A series of substituted 2-allyl-1,1-dimethylisoureas (allyl N,N-dimethylcarbamimidates) was prepared by the reaction of the corresponding allylic alcohols with dimethylcyanamide in the presence of sodium hydride. Treatment of the isoureas with mercur
Autor:
Roshantha A.S. Chandraratna, Alan T. Johnson, Berket Khalifa, Elliott S. Klein, Liming Wang, Min Teng, Tien T. Duong
Publikováno v:
Journal of medicinal chemistry. 40(16)
The syntheses and full retinoid receptor characterization of a novel series of retinoic acid receptor alpha (RAR alpha) antagonists, 1-5, are described. These compounds bind with high affinity to RAR alpha but were completely inactive in gene transac