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Autor:
Duc Anh Le, Thanh Huyen Doan, Van Dung Vu, Anh Tuan Hoang, Quang Thuan Pham, Thanh Dong Vu, Duc Bao Ninh, Tien Luc Vu, Van Chinh Luu, Ngoc Hung Truong
Publikováno v:
Journal of Military Science and Technology. :30-36
A five-step procedure was used to synthesize four novel conjugates of AZT and adenosine with quinazolinone scaffold. In the last step, alkynes-1 of quinazolinone were coupled to adenosine azide and AZT by Click chemistry to yield the designed conjuga