Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Tien L Huang"'
Autor:
Michela Murdocca, Osvaldo Andrade Santos-Filho, Claudia De Masi, Edivaldo dos Santos Rodrigues, Claudia Valeria Campos de Souza, Riccardo De Santis, Donatella Amatore, Andrea Latini, Rossella Schipani, Lino di Rienzo Businco, Bruno Brandimarte, Giorgia Grilli, Tien L Huang, Annie S Mayence, Florigio Lista, Andrea Duranti, Federica Sangiuolo, Jean Jacques Vanden Eynde, Giuseppe Novelli
Publikováno v:
Biology Direct, Vol 19, Iss 1, Pp 1-14 (2024)
Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is reliably one of the largest pandemics the world has suffered in recent years. In the search for non-biological antivirals, special emphasis was placed on drug repurposing to
Externí odkaz:
https://doaj.org/article/22eadf0fa2714ca38385e40ea9142bcb
Publikováno v:
Molecules, Vol 20, Iss 3, Pp 3898-3941 (2015)
Histone dacetylases (HDACs) are a group of enzymes that remove acetyl groups from histones and regulate expression of tumor suppressor genes. They are implicated in many human diseases, especially cancer, making them a promising therapeutic target fo
Externí odkaz:
https://doaj.org/article/a47257f7e7a24c4e91a0f41b4c4f55f9
Publikováno v:
Molecules, Vol 18, Iss 9, Pp 11250-11263 (2013)
A facile three step synthesis of a group of N1,N5-bis[4-(5-alkyl-1,2,4-oxadiazol-3-yl)phenyl]glutaramides, N1,N5-bis[4-(1,2,4-oxadiazol-3-yl)phenyl]glutaramide and N1,N5-bis[4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)phenyl]glutaramide is described. T
Externí odkaz:
https://doaj.org/article/7fd27c08e4344fe9a74c66a4c496b8f0
Autor:
Julien Laurent, Dimitri Stanicki, Tien L. Huang, Eduardo Dei-Cas, Muriel Pottier, El Mouktar Aliouat, Jean Jacques Vanden Eynde
Publikováno v:
Molecules, Vol 15, Iss 6, Pp 4283-4293 (2010)
A library of 19 novel 4-(4-phenylpiperazine-1-yl)benzamidines has been synthesized and evaluated in vitro against Pneumocystis carinii. Among these compounds, N-ethyl- and N-hexyl-4-(4-phenylpiperazine-1-yl)benzamidines emerged as the most promising
Externí odkaz:
https://doaj.org/article/e63f63af668c4b5885953c80ad55744e
Autor:
Jean J. Vanden Eynde, Annie Mayence, Madhusoodanan Mottamal, Cyrus J. Bacchi, Nigel Yarlett, Marcel Kaiser, Reto Brun, Tien L. Huang
Publikováno v:
Pharmaceuticals, Vol 9, Iss 2, p 20 (2016)
A series of 15 alkanediamide-linked bisbenzamidines and related analogs was synthesized and tested in vitro against two Trypanosoma brucei (T.b.) subspecies: T.b. brucei and T.b. rhodesiense, Trypanosoma cruzi, Leishmania donovani and two Plasmodium
Externí odkaz:
https://doaj.org/article/5058fb26228c47a4bb981b2eea64d1b9
Autor:
Annie Mayence, Tien L. Huang, Jean Jacques Vanden Eynde, Travis Korosh, Emmanuel Bujans, Canan Karaalioglu, Mary Morada, Nigel Yarlett
Publikováno v:
Chemical Biology & Drug Design. 90:489-495
A bisoxyphenylene-bisbenzimidazole series with increasing aliphatic chain length (CH2 to C10H20) containing a meta (m) or para (p) benzimidazole linkage to the phenylene ring was tested for ability to inhibit the growth of metronidazole susceptible (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20e6aed7938840979ea1fef2bc97f63d
https://doi.org/10.1111/cbdd.12972
https://doi.org/10.1111/cbdd.12972
Publikováno v:
Future Medicinal Chemistry. 7:2485-2505
Background: The Wnt signaling pathway involves secreted glycoproteins that bind to the Frizzled family receptors to activate intracellular signal transduction events that regulate cell proliferation, apoptosis, cell migration and many critical aspect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::449fa45733ca8cf459e7a6d4096ff46e
https://doi.org/10.4155/fmc.15.159
https://doi.org/10.4155/fmc.15.159
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:1983-1992
Increasing the affinity of diamidines for AT-rich regions of DNA has long been an important goal of medicinal chemists who wanted to improve the antiparasitic and antifungal properties of that class of derivatives. In recent years it was demonstrated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e379af6677edef31b45090e247e68be
https://doi.org/10.1016/j.bmc.2014.02.049
https://doi.org/10.1016/j.bmc.2014.02.049
Autor:
Dominic Bastien, Jean Jacques Vanden Eynde, Jacynthe L. Toulouse, Tien L. Huang, Maximilian C. C. J. C. Ebert, Florent Perron, Annie Mayence, Joelle N. Pelletier, Natalia Kadnikova, Delphine Forge
Publikováno v:
Journal of Medicinal Chemistry. 55:3182-3192
The continuously increasing use of trimethoprim as a common antibiotic for medical use and for prophylactic application in terrestrial and aquatic animal farming has increased its prevalence in the environment. This has been accompanied by increased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ce5fd749cb5977beb3577873d342d63
https://doi.org/10.1021/jm201645r
https://doi.org/10.1021/jm201645r
Autor:
Marcel Kaiser, Jean Jacques Vanden Eynde, Nigel Yarlett, Tien L. Huang, Reto Brun, Annie Mayence
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:7493-7500
A small library of 26 2,2'-[alkane-α,ω-diylbis(oxyphenylene)]bis-1H-benzimidazoles has been prepared and evaluated against Giardia intestinalis, Entamoeba histolytica, Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani, and Plas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccf008b7129c1f71b7d0dd3394e58cb5
https://doi.org/10.1016/j.bmc.2011.10.039
https://doi.org/10.1016/j.bmc.2011.10.039