Viral Determinants of miR-122-Independent Hepatitis C Virus Replication

Autor: Sharon E. Hopcraft, Kristopher D. Azarm, Benjamin Israelow, Nicolas Lévêque, Megan C. Schwarz, Tien-Huei Hsu, Matthew T. Chambers, Marion Sourisseau, Bert L. Semler, Matthew J. Evans

Publikováno v: mSphere, Vol 1, Iss 1 (2016)

ABSTRACT Hepatitis C virus (HCV) replication requires binding of the liver-specific microRNA (miRNA) miR-122 to two sites in the HCV 5′ untranslated region (UTR). Although we and others have shown that viral genetics impact the amount of active miR

Externí odkaz: https://doaj.org/article/ef738360aa8246348fe99a4903d25002

Identifying host factors that regulate viral infection.

Autor: Tien-Huei Hsu, Katherine R Spindler

Publikováno v: PLoS Pathogens, Vol 8, Iss 7, p e1002772 (2012)

Externí odkaz: https://doaj.org/article/46a72ddb5eea4667b193a9426d3b020b

Viral Determinants of miR-122-Independent Hepatitis C Virus Replication

Autor: Nicolas Lévêque, Benjamin Israelow, Megan C. Schwarz, Matthew T. Chambers, Kristopher D. Azarm, Tien-Huei Hsu, Bert L. Semler, Marion Sourisseau, Sharon E. Hopcraft, Matthew J. Evans

Publikováno v: mSphere, Vol 1, Iss 1 (2016)
mSphere
mSphere, vol 1, iss 1
Hopcraft, SE; Azarm, KD; Israelow, B; Leveque, N; Schwarz, MC; Hsu, T-H; et al.(2016). Viral Determinants of miR-122 Independent Hepatitis C Virus Replication. MSPHERE, 1(1). doi: 10.1128/mSphere.00009-15. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/7cg1054r

Hepatitis C virus (HCV) is the leading cause of liver cancer in the Western Hemisphere. HCV infection requires miR-122, which is expressed only in liver cells, and thus is one reason that replication of this virus occurs efficiently only in cells of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::699142a2b0e6c259cb3123ff240c1e7c
https://journals.asm.org/doi/10.1128/mSphere.00009-15

Usage of Integrin and Heparan Sulfate as Receptors for Mouse Adenovirus Type 1

Autor: Katherine R. Spindler, Tien Huei Hsu, Shanna L. Ashley, Sharmila Raman

Publikováno v: Journal of Virology. 83:2831-2838

Adenovirus fiber knobs are the capsid components that interact with binding receptors on cells, while an Arg-Gly-Asp (RGD) sequence usually found in the penton base protein is important for the interaction of most adenoviruses with integrin entry rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::563811b231fa96955286f35563d69689
https://doi.org/10.1128/jvi.02368-08

A T-to-G Transversion at Nucleotide −567 Upstream of HBG2 in a GATA-1 Binding Motif Is Associated with Elevated Hemoglobin F▿

Autor: Hong-Yuan Luo, George P. Patrinos, Lalana Nuntakarn, Ross C. Hardison, Martin H. Steinberg, Cathy G. Rosenfield, Raveen K. Basran, Zhi-yi Chen, David H.K. Chui, Daniel W.H. Mang, Tien Huei Hsu

Increased fetal hemoglobin (Hb F; alpha(2)gamma(2)) production in adults can ameliorate the clinical severity of sickle cell disease and beta-thalassemia major. Thus, understanding the regulation of gamma-globin gene expression and its silencing in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95a714c54ae02deddeb786f90cc6d373
https://europepmc.org/articles/PMC2447137/