Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Tiemin Sun"'
Autor:
Jiang Yu, Wenfeng Gou, Haihua Shang, Yating Cui, Xiao Sun, Lingling Luo, Wenbin Hou, Tiemin Sun, Yiliang Li
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 952-972 (2022)
The poly (ADP-ribose) polymerase (PARP) inhibitors play a crucial role in cancer therapy. However, most approved PARP inhibitors cannot cross the blood-brain barrier, thus limiting their application in the central nervous system. Here, 55 benzodiazep
Externí odkaz:
https://doaj.org/article/b263a5cf0d02430aa54e1d1ed749ebc1
Publikováno v:
Molecules, Vol 28, Iss 2, p 527 (2023)
The dopamine D3 receptor (D3R) is an important central nervous system target for treating various neurological diseases. D3R antagonists modulate the improvement of psychostimulant addiction and relapse, while D3R agonists can enhance the response to
Externí odkaz:
https://doaj.org/article/4d14ed720dbc4ec7876194f5773c3160
Publikováno v:
Molecules, Vol 20, Iss 11, Pp 20926-20938 (2015)
Pyridinesulfonamide is an important fragment which has a wide range of applications in novel drugs. R- and S-isomers of 5-bromo-2-chloro-N-(1-phenylethyl)pyridine-3-sulfonamide have been synthesized, and the stereostructures have been researched. Sin
Externí odkaz:
https://doaj.org/article/1ea8a142237b4a759d98620e3c901ddb
Publikováno v:
Molecules, Vol 19, Iss 6, Pp 7770-7784 (2014)
An in situ IR technique was applied in the selective synthesis of the key intermediate for rapamycin derivatives, which made the reaction endpoint easily defined. This technology solved a bothersome problem in the preparation of rapamycin derivatives
Externí odkaz:
https://doaj.org/article/6fa8546a91f94f6baab4b045cc259704
Autor:
Yang Zhang, Yan Yang, Sen Zhao, Zhichao Yang, Hong Yang, J. Paul Fawcett, Youxin Li, Jingkai Gu, Tiemin Sun
Publikováno v:
Molecules, Vol 18, Iss 12, Pp 14920-14934 (2013)
O-Desmethylvenlafaxine (desvenlafaxine, ODV) is a recently approved antidepressant which in some clinical studies failed to meet a satisfactory end-point. The aim of this study was to prepare a series of phenolic esters of ODV and evaluate their pote
Externí odkaz:
https://doaj.org/article/2536e831fb0d4be5869842c04dcd4689
Publikováno v:
Molecules, Vol 16, Iss 6, Pp 5130-5141 (2011)
A series of N-methyl-4-phenoxypicolinamide derivatives were synthesized and evaluated in vitro for their cytotoxic activity against A549, H460 and HT29 cell lines. Pharmacological data indicated that some of the target compounds possessed marked anti
Externí odkaz:
https://doaj.org/article/4ecfa4e14f014b84af68a82b1de7d3c7
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120216 (2015)
A method for the separation of folinic acid diastereomers by capillary electrophoresis in chiral separation media was developed. Aiming to achieve a good separation of the anionic analytes, a newly synthesized cationic β-cyclodextrin derivative, mon
Externí odkaz:
https://doaj.org/article/b13e58e6bde54e81a81315d5f124773d
Autor:
Hui Lei, Xiuping Lin, Li Han, Jian Ma, Qingjuan Ma, Jialiang Zhong, Yonghong Liu, Tiemin Sun, Jinhui Wang, Xueshi Huang
Publikováno v:
Marine Drugs, Vol 15, Iss 3, p 69 (2017)
Four new compounds, including two isocoumarins, pestaloisocoumarins A and B (1, 2), one sesquiterpenoid degradation, isopolisin B (4), and one furan derivative, pestalotiol A (5), together with one known isocoumarin, gamahorin (3), and three chlorina
Externí odkaz:
https://doaj.org/article/0f5b3cbd842044eb87a9b4b44cb72b0b
Publikováno v:
Molecules, Vol 21, Iss 7, p 875 (2016)
A series of bedaquiline analogs containing H-bond donors were designed as anti-Mycobacterium tuberculosis drugs. A pair of diastereoisomers (R/S- and S/S-isomers) was selected from these designed compounds for synthetic and stereochemical research. T
Externí odkaz:
https://doaj.org/article/63f4adf662eb49369d92ee3dc9ab25df
Publikováno v:
Acta Crystallographica Section E, Vol 66, Iss 3, Pp o716-o716 (2010)
In the title compound, C17H20Cl2N4O, the piperazine ring adopts a chair conformation and the dihedral angle between the pyridazine ring and the benzene ring is 36.3 (1)°. In the crystal, weak C—H...O and C—H...(N,N) interactions help to establis
Externí odkaz:
https://doaj.org/article/82d59652d68142479b34951de465c138