Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Tieguang Yao"'
Autor:
Jeffrey W. Johannes, Fiona Pachl, Amber Balazs, Tieguang Yao, C. Larner, Lisa McWilliams, Marianne Schimpl, Scott W. Martin, Kevin J. Embrey, Tom D. Heightman, Paul Hemsley, Jonathan P. Orme, Derek Barratt, Giuditta Illuzzi, Andrew Madin, Paolo Di Fruscia, Avipsa Ghosh, Martin J. Packer, Scott D. Edmondson, Elisabetta Leo, Xiaolan Zheng, Matthew D. Chuba, Xiaohui Pei, Mark J. O'Connor, Verity Talbot, Ke Zhang, Stephen Fawell, Elizabeth Underwood, Anna Staniszewska, Lina Liu, Lin Xue, Sonja J. Gill, Anders Gunnarsson, Andrew Pike, Susan E. Critchlow, Jeffrey G. Varnes, Andrew X. Zhang, Sébastien L. Degorce, J. Lane, Sudhir M. Hande, Hongyao She, Sabina Cosulich, Michal Bista
Publikováno v:
Journal of Medicinal Chemistry. 64:14498-14512
Poly-ADP-ribose-polymerase (PARP) inhibitors have achieved regulatory approval in oncology for homologous recombination repair deficient tumors including BRCA mutation. However, some have failed in combination with first-line chemotherapies, usually
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d5da59f02fe0bf1798c2492422c31c3
https://doi.org/10.1021/acs.jmedchem.1c01012
https://doi.org/10.1021/acs.jmedchem.1c01012
Autor:
Tieguang Yao, Liangwei Wu, Craig S. Donald, Douglas Ferguson, Lei Wang, Andrew Pike, Jianyan Wang, Justin Cidado, Dedong Wu, Kurt Gordon Pike, Kumar Thakur, Chungang Gu, Calum Cook, James Horstick, Tyler Grebe, Theresa Proia, Darren Stead, Alexander Hird, Michelle Lamb, Wenlin Shao, Nichole O'Connell, Yun Jiang, Sudhir M. Hande, Bin Yang, Janet Hawkins, Barlaam Bernard Christophe, Neil Sumner, Melissa Vasbinder, Andrew D. Ferguson, Jane E. Moore, Jeffrey G. Varnes, Bryan Roberts, Maryann San Martin, Lisa Drew, Ujjal Sarkar, Allan Dishington, Chris De Savi, Robert Casella, Steve C. Glossop, Jane L. Holmes, Thomas M. McGuire
Publikováno v:
Journal of Medicinal Chemistry. 63:15564-15590
A CDK9 inhibitor having short target engagement would enable a reduction of Mcl-1 activity, resulting in apoptosis in cancer cells dependent on Mcl-1 for survival. We report the optimization of a series of amidopyridines (from compound 2), focusing o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46785e29e943e36954f937d0f6b5666c
https://doi.org/10.1021/acs.jmedchem.0c01754
https://doi.org/10.1021/acs.jmedchem.0c01754
Autor:
Lei Wang, Allan Dishington, Jane E. Moore, Kurt Gordon Pike, Wenlin Shao, Andrew Lister, Anil Patel, Lorraine A. Hassall, Sudhir M. Hande, Jane L. Holmes, Douglas Ferguson, Thomas M. McGuire, Jeffrey G. Varnes, Lin Xue, Chungang Gu, Tieguang Yao, Barlaam Bernard Christophe, Lisa Drew, Janet Hawkins, Liangwei Wu, Chris De Savi, Melissa Vasbinder, Andrew D. Ferguson, Darren Stead, Ujjal Sarkar, Michelle Lamb, Nichole O'Connell, Bin Yang, Alexander Hird
Publikováno v:
Journal of medicinal chemistry. 64(20)
Optimization of a series of azabenzimidazoles identified from screening hit 2 and the information gained from a co-crystal structure of the azabenzimidazole-based lead 6 bound to CDK9 led to the discovery of azaindoles as highly potent and selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::640b617db421bd84b5fcddd8d48d0b58
https://pubmed.ncbi.nlm.nih.gov/34647738
https://pubmed.ncbi.nlm.nih.gov/34647738
Autor:
Darren Cross, Matthew J. Martin, Carine M. Guérot, Nicolas Floc'h, Clare Gregson, Jonathan P. Orme, Michal Bista, Lin Xue, Xu Li, Amar Rahi, Xiliang Zhao, Richard A. Ward, L. Evans, Gail L. Wrigley, Arash Mosallanejad, Tieguang Yao, Claire McWhirter, David J. Hargreaves, Nicola Colclough, Sue Bickerton, Darren Mckerrecher, Peter Barton, Yang Ye, Yi Liu, Marta Wylot, M. Raymond V. Finlay, Xiaoming Kang, Eva M. Lenz, Daniel O'Neill, Verity Talbot, Olivier Lorthioir, Paul D. Smith
Publikováno v:
Journal of medicinal chemistry. 64(18)
The epidermal growth factor receptor (EGFR) harboring activating mutations is a clinically validated target in non-small-cell lung cancer, and a number of inhibitors of the EGFR tyrosine kinase domain, including osimertinib, have been approved for cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58199c545ee296c2c44cec7db12bfba5
https://pubmed.ncbi.nlm.nih.gov/34491761
https://pubmed.ncbi.nlm.nih.gov/34491761
Publikováno v:
Chemical Society Reviews. 44:6494-6518
Cyclophanes have been firmly entrenched as a distinct class of compounds for well over half a century. The two main factors that have kept this field of chemistry going so strongly for such a long time are tremendous structural diversity and the inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::258613e55b0dc4743c72e98d4c72f49f
https://doi.org/10.1039/c5cs00274e
https://doi.org/10.1039/c5cs00274e
Publikováno v:
Pure and Applied Chemistry. 80:533-546
A strategy for the synthesis of cyclophenacene-type aromatic belts (or armchair nanotube segments) that relies upon a valence isomerization/dehydrogenation reaction is described, and progress toward achieving this goal is presented.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41609751ce9c05ef3154a0bb3959db93
https://doi.org/10.1351/pac200880030533
https://doi.org/10.1351/pac200880030533
Publikováno v:
ChemInform. 46
Cyclophanes have been firmly entrenched as a distinct class of compounds for well over half a century. The two main factors that have kept this field of chemistry going so strongly for such a long time are tremendous structural diversity and the inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb0e8a9ecde785f6e868ccb6a5f45e49
https://doi.org/10.1002/chin.201544253
https://doi.org/10.1002/chin.201544253
Publikováno v:
Pure & Applied Chemistry; Mar2008, Vol. 80 Issue 3, p533-546, 14p
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Autor:
Johannes, Jeffrey W., Denz, Christopher R., Su, Nancy, Wu, Allan, Impastato, Anna C., Mlynarski, Scott, Varnes, Jeffrey G., Prince, D. Bryan, Cidado, Justin, Gao, Ning, Haddrick, Malcolm, Jones, Natalie H., Li, Shaobin, Li, Xiuwei, Liu, Yang, Nguyen, Toan B., O'Connell, Nichole, Rivers, Emma, Robbins, Daniel W., Tomlinson, Ronald
Publikováno v:
ChemMedChem; 2/6/2018, Vol. 13 Issue 3, p231-235, 5p