Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Tiechao Li"'
Autor:
Margaret M. Faul, Christine A. Kumrich, Bryan A. Anderson, Concha Sanchez-Martinez, Tammy B. DeHahn, Harold B. Brooks, Catherine A. Ogg, Michael Paal, Robert M. Campbell, Carmen Somoza, Tiechao Li, Leonard L. Winneroski, Bharvin K. R. Patel, Chuan Shih, Zhou Xun, Jill R. Wagner, Eileen L. Considine, Guoxin Zhu, Scott A. Watkins, Jack A. Dempsey, Richard M. Schultz, Charles D. Spencer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:3835-3839
The synthesis of new analogues of Arcyriaflavin A in which one indole ring is replaced by an aryl or heteroaryl ring is described. These new series of aryl[a]pyrrolo[3,4-c]carbazoles were evaluated as inhibitors of Cyclin D1-CDK4. A potent and select
Autor:
Concha Sanchez-Martinez, Chuan Shih, Richard M. Schultz, Guoxin Zhu, Charles D. Spencer, Tiechao Li, Catherine A. Ogg, Bharvin K. R. Patel, Eileen L. Considine, Jack A. Dempsey, Faming Zhang, Harold B. Brooks, Tammy B. DeHahn, Scott A. Watkins
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:3841-3846
A series of indolo[2,3-a]pyrrolo[3,4-c]carbazoles and their bis-indolylmaleimides precursors have been prepared in order to compare their activity as D1-CDK4 inhibitors. Both enzymatic and antiproliferative assays have shown that the structurally mor
Publikováno v:
Tetrahedron Letters. 39:2459-2462
Naphthaquinopyrans 5a-d, 10 and 12 have been converted to benzoisochromene IIb via base-promoted air oxidation. A mechanism is proposed to account for the observed results. Use of peroxide scavenger was found necessary for consistent yields. IIb prov
Publikováno v:
The Journal of Organic Chemistry. 62:6598-6602
Oxidation of bisbenzyl ethers was studied using 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ). Compared to other benzylic oxidations such as Kornblum type reaction of benzyl bromides or MnO2 oxidation of benzyl alcohols, DDQ oxidation offered advantages
Publikováno v:
ChemInform. 29
Naphthaquinopyrans 5a-d, 10 and 12 have been converted to benzoisochromene IIb via base-promoted air oxidation. A mechanism is proposed to account for the observed results. Use of peroxide scavenger was found necessary for consistent yields. IIb prov
Autor:
S. A. Noble, Michael Joseph Luzzio, Wuyi Wang, Robert Milburn, J. Yates, Tiechao Li, E. Hinnant, Giorgio Attardo
Publikováno v:
ChemInform. 29
Autor:
Sehila Pleite, Mario Barberis, Robert Dean Dally, Eugenio de Diego, White Wesley Todd, Miriam del Prado, Concepcion Sanchez-Martinez, Timothy Alan Shepherd, Bryan D. Anderson, Luisa M. Martín Cabrejas, Chuan Shih, Jeffrey A. Wolos, Li C. Li, Carmen Dominguez, Alfonso De Dios, Beatriz López de Uralde, C. Richard Nevill, Enrique Jambrina, Arindam Chatterjee, Carlos Montero, Richard C. Schultz, Leticia Perez, Paul Lee, Carlos Jaramillo, Tiechao Li, María José Lorite, † Jaime Blanco-Urgoiti, John E. Toth, Robert M. Campbell, Rosanne Bonjouklian, Mary M. Mader
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(1)
Herein we report investigations into the p38alpha MAP kinase activity of trisubstituted imidazoles that led to the identification of compounds possessing highly potent in vivo activity. The SAR of a novel series of imidazopyridines is demonstrated as
Autor:
Jose Eduardo Lopez, James H Wikel, Mary Margaret Mader, Beth A Hollister, Luisa M Martin Cabrejas, Beverly Teicher, James A Aikins, Enrique Alvarez, Philip A Hipskind, Deborah D Giera, Michael E Richett, Rafael Ferritto, Karen L Lobb, Denis J. McCann, Gregory L Durst, Wesley T White, Alfonso De Dios, Cora Sue Grossman, John E. Reilly, Eileen L Considine, Victoriano Molero, Shih Chuan, Tiechao Li, Ho-Shen Lin, Beatriz Lopez, Zhongping Huang, Philip W Iversen, Yiu-Yin Cheung, Kevin L Law
Publikováno v:
Journal of medicinal chemistry. 47(22)
Two closely related diaryl acylsulfonamides were recently reported as potent antitumor agents against a broad spectrum of human tumor xenografts (colon, lung, breast, ovary, and prostate) in nude mice. Especially intriguing was their activity against
Autor:
Richard M. Schultz, Charles D. Spencer, Bryan D. Anderson, Margaret M. Faul, Beverly Teicher, Harold B. Brooks, Scott Eugene Conner, Chuan Shih, Xun Zhou, Cathy Ogg, Scott A. Watkins, Robert M. Campbell, Bharvin K. R. Patel, Eileen L. Considine, Tiechao Li, Guoxin Zhu, Jack A. Dempsey
Publikováno v:
Journal of medicinal chemistry. 46(11)
Novel substituted indolocarbazoles were synthesized, and their kinase inhibitory capability was evaluated in vitro. 6-Substituted indolocarbazoles 4 were found to be potent and selective D1/CDK4 inhibitors. 4d and 4h exhibited potent and ATP-competit
Autor:
Micheal J. Luzzio, E. Hinnant, J. Yates, Tiechao Li, Wuyi Wang, Robert Milburn, Giorgio Attardo, Stuart A. Noble
Publikováno v:
Bioorganicmedicinal chemistry letters. 8(13)
Novel antitumor 5,10-dihydro-5,10-dioxo-1 H -benzo[ g ]isochromene-3-carboxamides were discovered.