Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Tiebing Liang"'
Autor:
Bin Qiu, Zhaohui Zhong, Longyu Dou, Yuxue Xu, Yi Zou, Korri Weldon, Jun Wang, Lingling Zhang, Ming Liu, Kent E. Williams, John Paul Spence, Richard L. Bell, Zhao Lai, Weidong Yong, Tiebing Liang
Publikováno v:
Cell & Bioscience, Vol 14, Iss 1, Pp 1-25 (2024)
Abstract Background and aims Previously, we found that FK506 binding protein 51 (Fkbp51) knockout (KO) mice resist high fat diet-induced fatty liver and alcohol-induced liver injury. The aim of this research is to identify the mechanism of Fkbp51 in
Externí odkaz:
https://doaj.org/article/3e226da478814dd7a0ba3d0480b1c15d
Autor:
Nicholas R. Powell, Tiebing Liang, Joseph Ipe, Sha Cao, Todd C. Skaar, Zeruesenay Desta, Hui-Rong Qian, Philip J. Ebert, Yu Chen, Melissa K. Thomas, Naga Chalasani
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
This study characterizes expression of pharmacogenes across the histological NAFLD severity spectrum. Here, the authors show the downregulation of CYP2C19 in NAFLD which supports developing personalized medicine approaches for drugs sensitive to meta
Externí odkaz:
https://doaj.org/article/a90be45cc8cb455db34c7afe0b5d1181
Autor:
Kent E. Williams, Yi Zou, Bin Qiu, Tatsuyoshi Kono, Changyong Guo, Dawn Garcia, Hanying Chen, Tamara Graves, Zhao Lai, Carmella Evans-Molina, Yao-Ying Ma, Suthat Liangpunsakul, Weidong Yong, Tiebing Liang
Publikováno v:
Cells, Vol 13, Iss 1, p 89 (2023)
High levels of alcohol intake alter brain gene expression and can produce long-lasting effects. FK506-binding protein 51 (FKBP51) encoded by Fkbp5 is a physical and cellular stress response gene and has been associated with alcohol consumption and wi
Externí odkaz:
https://doaj.org/article/bd9ba3e9865a4a2db1ec431a34823b1f
Autor:
Tiebing Liang, Janaiah Kota, Kent E. Williams, Romil Saxena, Samer Gawrieh, Xiaoling Zhong, Teresa A. Zimmers, Naga Chalasani
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 19, p 14564 (2023)
MicroRNA-29a (miR-29a) is a well characterized fibro-inflammatory molecule and its aberrant expression is linked to a variety of pathological liver conditions. The long-term effects of a high-fat diet (HFD) in combination with different levels of EtO
Externí odkaz:
https://doaj.org/article/5beccac89bf04bf9a09f941c5b4ea189
Autor:
John Paul Spence, Jill L. Reiter, Bin Qiu, Hao Gu, Dawn K. Garcia, Lingling Zhang, Tamara Graves, Kent E. Williams, Paula J. Bice, Yi Zou, Zhao Lai, Weidong Yong, Tiebing Liang
Publikováno v:
Frontiers in Genetics, Vol 9 (2018)
Humans show sex differences related to alcohol use disorders (AUD). Animal model research has the potential to provide important insight into how sex differences affect alcohol consumption, particularly because female animals frequently drink more th
Externí odkaz:
https://doaj.org/article/a7c38cbd3c80470aab9fb44238b5dff9
Autor:
Chiao-Ling Lo, Amy C Lossie, Tiebing Liang, Yunlong Liu, Xiaoling Xuei, Lawrence Lumeng, Feng C Zhou, William M Muir
Publikováno v:
PLoS Genetics, Vol 12, Iss 8, p e1006178 (2016)
Investigations on the influence of nature vs. nurture on Alcoholism (Alcohol Use Disorder) in human have yet to provide a clear view on potential genomic etiologies. To address this issue, we sequenced a replicated animal model system bidirectionally
Externí odkaz:
https://doaj.org/article/71905cf4edb941e1982ed04d29de98bf
Autor:
Tiebing Liang, Mouhamad Alloosh, Lauren N Bell, Allison Fullenkamp, Romil Saxena, William Van Alstine, Phelan Bybee, Klára Werling, Michael Sturek, Naga Chalasani, Howard C Masuoka
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0124173 (2015)
BACKGROUND:Ossabaw miniature swine when fed a diet high in fructose, saturated fat and cholesterol (NASH diet) develop metabolic syndrome and nonalcoholic steatohepatitis (NASH) characterized by liver injury and fibrosis. This study was conducted to
Externí odkaz:
https://doaj.org/article/54110bae19154614bf2eec8b7146279f
Autor:
Jonathon D Klein, Jeremy B Sherrill, Gabriella M Morello, Phillip J San Miguel, Zhenming Ding, Suthat Liangpunsakul, Tiebing Liang, William M Muir, Lawrence Lumeng, Amy C Lossie
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e110501 (2014)
Research is uncovering the genetic and biochemical effects of consuming large quantities of alcohol. One prime example is the J- or U-shaped relationship between the levels of alcohol consumption and the risk of atherosclerotic cardiovascular disease
Externí odkaz:
https://doaj.org/article/530e37dc18a84048a5399d50a43cd3f0
Autor:
Raj Vuppalanchi, Tiebing Liang, Chirayu Pankaj Goswami, Rohit Nalamasu, Lang Li, David Jones, Rongrong Wei, Wanqing Liu, Vishal Sarasani, Sarath Chandra Janga, Naga Chalasani
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74471 (2013)
Liver cirrhosis is associated with decreased hepatic cytochrome P4503A (CYP3A) activity but the pathogenesis of this phenomenon is not well elucidated. In this study, we examined if certain microRNAs (miRNA) are associated with decreased hepatic CYP3
Externí odkaz:
https://doaj.org/article/42e0f372ad1b41b7910d9ea0dd8242ef
Autor:
Bin Qiu, Susan E. Luczak, Tamara L. Wall, Aaron M. Kirchhoff, Yuxue Xu, Mimy Y. Eng, Robert B. Stewart, Weinian Shou, Stephen L. Boehm, Julia A. Chester, Weidong Yong, Tiebing Liang
Publikováno v:
International Journal of Molecular Sciences, Vol 17, Iss 8, p 1271 (2016)
FKBP5 encodes FK506-binding protein 5, a glucocorticoid receptor (GR)-binding protein implicated in various psychiatric disorders and alcohol withdrawal severity. The purpose of this study is to characterize alcohol preference and related phenotypes
Externí odkaz:
https://doaj.org/article/7a43cea1c070404ba5f4758607d453c6