Výsledky vyhledávání

Akademický článek

EHMT2 suppresses the variation of transcriptional switches in the mouse embryo

Autor: Tie-Bo Zeng, Nicholas Pierce, Ji Liao, Purnima Singh, Kin Lau, Wanding Zhou, Piroska E. Szabó

Publikováno v: PLoS Genetics, Vol 17, Iss 11 (2021)

EHMT2 is the main euchromatic H3K9 methyltransferase. Embryos with zygotic, or maternal mutation in the Ehmt2 gene exhibit variable developmental delay. To understand how EHMT2 prevents variable developmental delay we performed RNA sequencing of muta

Externí odkaz: https://doaj.org/article/07cfe93f4d4c429a8647ea0c1b891960

Zobrazit plný text záznamu

Akademický článek

Prenatal correction of IGF2 to rescue the growth phenotypes in mouse models of Beckwith-Wiedemann and Silver-Russell syndromes

Autor: Ji Liao, Tie-Bo Zeng, Nicholas Pierce, Diana A. Tran, Purnima Singh, Jeffrey R. Mann, Piroska E. Szabó

Publikováno v: Cell Reports, Vol 34, Iss 6, Pp 108729- (2021)

Summary: Beckwith-Wiedemann syndrome (BWS) and Silver-Russell syndrome (SRS) are imprinting disorders manifesting as aberrant fetal growth and severe postnatal-growth-related complications. Based on the insulator model, one-third of BWS cases and two

Externí odkaz: https://doaj.org/article/3c6bac68b35c49c3ac02056d59a4d489

Zobrazit plný text záznamu

Immunochemical Detection of Modified Cytosine Species in Mammalian Preimplantation Embryos

Autor: Tie-Bo, Zeng, Piroska E, Szabó

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2198

DNA methylation undergoes dynamic changes at the genome-wide scale during the early steps of mammalian embryo development. Immunochemical detection of 5-methylcytosine (5mC) in the zygote has led to the discovery that a global loss of DNA methylation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::34959c800a4f8ff5f87b69c98d0ba079
https://pubmed.ncbi.nlm.nih.gov/32822029

Zobrazit plný text záznamu