Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Tie Yan Han"'
Autor:
Yong-Yu Liu, Tie Yan Han, Jing Yuan Yu, Arie Bitterman, Ahn Le, Armando E. Giuliano, Myles C. Cabot
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 5, Pp 933-940 (2004)
High glucosylceramide synthase (GCS) activity is one factor contributing to multidrug resistance (MDR) in breast cancer. Enforced GCS overexpression has been shown to disrupt ceramide-induced apoptosis and to confer resistance to doxorubicin. To exam
Externí odkaz:
https://doaj.org/article/23122ba0868a4d80a9f4f8cedec65284
Autor:
Jing Yuan Yu, Myles C. Cabot, Armando E. Giuliano, Yong-Yu Liu, Arie Bitterman, Ahn Le, Tie Yan Han
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 5, Pp 933-940 (2004)
High glucosylceramide synthase (GCS) activity is one factor contributing to multidrug resistance (MDR) in breast cancer. Enforced GCS overexpression has been shown to disrupt ceramide-induced apoptosis and to confer resistance to doxorubicin. To exam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36a7ac621f086a8365094c568ea5cae5
https://doi.org/10.1194/jlr.m300486-jlr200
https://doi.org/10.1194/jlr.m300486-jlr200
Publikováno v:
The FASEB Journal. 15:719-730
Ceramide glycosylation, through glucosylceramide synthase (GCS), allows cellular escape from ceramide-induced programmed cell death. This glycosylation event confers cancer cell resistance to cytotoxic anticancer agents [Liu, Y. Y., Han, T. Y., Giuli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf2e134542035a2214479066ab5318bf
https://doi.org/10.1096/fj.00-0223com
https://doi.org/10.1096/fj.00-0223com
Publikováno v:
Journal of Biological Chemistry. 274:1140-1146
Multidrug-resistant cancer cells display elevated levels of glucosylceramide (Lavie, Y., Cao, H. T., Volner, A., Lucci, A., Han, T. Y., Geffen, V., Giuliano, A. E., and Cabot, M. C. (1997) J. Biol. Chem. 272, 1682-1687). In this study, we have introd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ae3ee9943f542119f6b435027684ac9
https://doi.org/10.1074/jbc.274.2.1140
https://doi.org/10.1074/jbc.274.2.1140
Publikováno v:
FEBS Letters. 431:185-188
In this study we demonstrate that the multidrug resistance (MDR) modulator PSC 833 is a potent agonist of ceramide metabolism. When added with [3H]serine or [3H]palmitic acid to the culture medium of MCF-7 cells, PSC 833, in a dose-responsive fashion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcf6581f9deefd129d67e8e72e3fbd9b
https://doi.org/10.1016/s0014-5793(98)00744-3
https://doi.org/10.1016/s0014-5793(98)00744-3
Autor:
Ralph C. Jones, Hui-ting Cao, Tie-Yan Han, Armando E. Giuliano, Myles C. Cabot, Zu-chuan Zhang, Yaakov Lavie
Publikováno v:
International Journal of Cancer. 70:567-574
The antiestrogen tamoxifen is widely used for endocrine therapy of breast cancer; however, the mechanisms of estrogen receptor-independent interactions of tamoxifen remain ill defined. Here we examine the effect of tamoxifen on the initial steps of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f6f8175fcc85188c50897b01bec1a37
https://doi.org/10.1002/(sici)1097-0215(19970304)70:5<567::aid-ijc13>3.0.co
https://doi.org/10.1002/(sici)1097-0215(19970304)70:5<567::aid-ijc13>3.0.co
Autor:
Valerie, Gouazé, Jing Y, Yu, Richard J, Bleicher, Tie-Yan, Han, Yong-Yu, Liu, Hongtao, Wang, Michael M, Gottesman, Arie, Bitterman, Armando E, Giuliano, Myles C, Cabot
Publikováno v:
Molecular cancer therapeutics. 3(5)
Resistance to natural product chemotherapy drugs is a major obstacle to successful cancer treatment. This type of resistance is often acquired in response to drug exposure; however, the mechanisms of this adverse reaction are complex and elusive. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ecdc66b93a7c0acc98dd30fba44ec188
https://pubmed.ncbi.nlm.nih.gov/15141021
https://pubmed.ncbi.nlm.nih.gov/15141021
Autor:
Hongtao Wang, Arthur E. Frankel, Myles C. Cabot, Scott H. Kaufmann, Tie Yan Han, Alex Senchenkov, Timothy Kottke
Publikováno v:
Blood. 98(6)
DT(388)-GM-CSF, a targeted fusion toxin constructed by conjugation of human granulocyte-macrophage colony-stimulating factor (GM-CSF) with the catalytic and translocation domains of diphtheria toxin, is presently in phase I trials for patients with r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ec6a09bba73b66ecf774db343adfba2
https://pubmed.ncbi.nlm.nih.gov/11535531
https://pubmed.ncbi.nlm.nih.gov/11535531
Autor:
Anthony G. Charles, Nora M. Hansen, Armando E. Giuliano, Myles C. Cabot, Yong Y. Liu, Tie-Yan Han
Publikováno v:
Cancer chemotherapy and pharmacology. 47(5)
Purpose: Taxol has emerged as a valuable antimitotic chemotherapeutic agent, particularly in advanced breast and ovarian cancers. Although much is known about cytotoxic mechanisms, the effectiveness of Taxol cannot be solely explained by microtubular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cb38705ec4bc6c88196dffb4432bf6a
https://pubmed.ncbi.nlm.nih.gov/11391861
https://pubmed.ncbi.nlm.nih.gov/11391861
Publikováno v:
The Journal of biological chemistry. 275(10)
Previous work from our laboratory demonstrated that increased competence to glycosylate ceramide conferred adriamycin resistance in MCF-7 breast cancer cells (Liu, Y. Y., Han, T. Y., Giuliano, A. E. , and M. C. Cabot. (1999) J. Biol. Chem. 274, 1140-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfd8d4b82ebd6f21dc5c9e5afe280ea2
https://pubmed.ncbi.nlm.nih.gov/10702281
https://pubmed.ncbi.nlm.nih.gov/10702281