Abnormal cell sorting and altered early neurogenesis in a human cortical organoid model of Protocadherin-19 clustering epilepsy.

Autor: Niu W; Department of Neurology, University of Michigan, Ann Arbor, MI, United States.; Department of Biological Sciences, University of Toledo, Toledo, OH, United States., Deng L; Department of Neurology, University of Michigan, Ann Arbor, MI, United States.; Department of Rehabilitation, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China., Mojica-Perez SP; Department of Neurology, University of Michigan, Ann Arbor, MI, United States., Tidball AM; Department of Neurology, University of Michigan, Ann Arbor, MI, United States., Sudyk R; Department of Neurology, University of Michigan, Ann Arbor, MI, United States., Stokes K; Department of Neurology, University of Michigan, Ann Arbor, MI, United States., Parent JM; Department of Neurology, University of Michigan, Ann Arbor, MI, United States.; Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, United States.; VA Ann Arbor Healthcare System, Ann Arbor, MI, United States.

Publikováno v: Frontiers in cellular neuroscience [Front Cell Neurosci] 2024 Apr 04; Vol. 18, pp. 1339345. Date of Electronic Publication: 2024 Apr 04 (Print Publication: 2024).

Deriving early single-rosette brain organoids from human pluripotent stem cells.

Autor: Tidball AM; Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, USA., Niu W; Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, USA., Ma Q; Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, USA., Takla TN; Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, USA., Walker JC; Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, USA., Margolis JL; Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, USA., Mojica-Perez SP; Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, USA., Sudyk R; Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, USA., Deng L; Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, USA., Moore SJ; Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, USA., Chopra R; Department of Neurology, Washington University School of Medicine, Saint Louis, MO, USA., Shakkottai VG; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA., Murphy GG; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA; Michigan Neuroscience Institute, University of Michigan Medical School, Ann Arbor, MI, USA., Yuan Y; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, USA., Isom LL; Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, USA; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, USA., Li JZ; Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, USA; Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, USA., Parent JM; Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, USA; Michigan Neuroscience Institute, University of Michigan Medical School, Ann Arbor, MI, USA; VA Ann Arbor Healthcare System, Ann Arbor, MI, USA. Electronic address: parent@med.umich.edu.

Publikováno v: Stem cell reports [Stem Cell Reports] 2023 Dec 12; Vol. 18 (12), pp. 2498-2514. Date of Electronic Publication: 2023 Nov 22.

Progress and potential of brain organoids in epilepsy research.

Autor: Brown, Rachel^1,2 (AUTHOR), Rabeling, Alexa^1,2 (AUTHOR), Goolam, Mubeen^1,2 (AUTHOR) mubeen.goolam@uct.ac.za

Publikováno v: Stem Cell Research & Therapy. 10/12/2024, Vol. 15 Issue 1, p1-10. 10p.

Variant-specific changes in persistent or resurgent sodium current in SCN8A-related epilepsy patient-derived neurons.

Autor: Tidball AM; Department of Neurology, University of Michigan, Ann Arbor, MI, USA., Lopez-Santiago LF; Department of Pharmacology, University of Michigan, Ann Arbor, MI, USA., Yuan Y; Department of Pharmacology, University of Michigan, Ann Arbor, MI, USA., Glenn TW; Department of Neurology, University of Michigan, Ann Arbor, MI, USA., Margolis JL; Department of Neurology, University of Michigan, Ann Arbor, MI, USA., Clayton Walker J; Department of Neurology, University of Michigan, Ann Arbor, MI, USA., Kilbane EG; Department of Neurology, University of Michigan, Ann Arbor, MI, USA., Miller CA; Child Neurology Services, Knoxville, TN, USA., Martina Bebin E; Department of Neurology, University of Alabama Birmingham School of Medicine, Birmingham, AL, USA.; Department of Pediatrics, University of Alabama Birmingham School of Medicine, Birmingham, AL, USA., Scott Perry M; Cook Children's Health Care System, Fort Worth, Texas, USA., Isom LL; Department of Neurology, University of Michigan, Ann Arbor, MI, USA.; Department of Pharmacology, University of Michigan, Ann Arbor, MI, USA.; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Parent JM; Department of Neurology, University of Michigan, Ann Arbor, MI, USA.; Ann Arbor VA Healthcare System, Ann Arbor, MI, USA.

Publikováno v: Brain : a journal of neurology [Brain] 2020 Oct 01; Vol. 143 (10), pp. 3025-3040.

Disruption of Dopamine Homeostasis Associated with Alteration of Proteins in Synaptic Vesicles: A Putative Central Mechanism of Parkinson's Disease Pathogenesis.

Autor: Xuanxiang Jin¹, Xiaoli Si², Xiaoguang Lei³, Huifang Liu⁴, Anwen Shao^5,6 shaoanwen@zju.edu.cn, Lingfei Li⁷ leelingfei@126.com

Publikováno v: Aging & Disease. Jun2024, Vol. 15 Issue 3, p1204-1226. 23p.