Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Tibor van Welsem"'
Autor:
Eliza Mari Kwesi-Maliepaard, Muddassir Malik, Tibor van Welsem, Remco van Doorn, Maarten H. Vermeer, Hanneke Vlaming, Heinz Jacobs, Fred van Leeuwen
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Cutaneous T-cell lymphomas (CTCLs) are a subset of T-cell malignancies presenting in the skin. The treatment options for CTCL, in particular in advanced stages, are limited. One of the emerging therapies for CTCL is treatment with histone deacetylase
Externí odkaz:
https://doaj.org/article/b241d9f6d9584cc68a04b26f8668305b
Autor:
Ila van Kruijsbergen, Monique P. C. Mulder, Michael Uckelmann, Tibor van Welsem, John de Widt, Aldo Spanjaard, Heinz Jacobs, Farid El Oualid, Huib Ovaa, Fred van Leeuwen
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
Protein ubiquitination is a key post-translational modification regulating a wide range of biological processes. Ubiquitination involves the covalent attachment of the small protein ubiquitin to a lysine of a protein substrate. In addition to its wel
Externí odkaz:
https://doaj.org/article/96f73bcacfac4bcd927a6cd4d515cee0
Autor:
Tessy Korthout, Deepani W Poramba-Liyanage, Ila van Kruijsbergen, Kitty F Verzijlbergen, Frank P A van Gemert, Tibor van Welsem, Fred van Leeuwen
Publikováno v:
PLoS Biology, Vol 16, Iss 7, p e2005542 (2018)
Transcription, replication, and repair involve interactions of specific genomic loci with many different proteins. How these interactions are orchestrated at any given location and under changing cellular conditions is largely unknown because systema
Externí odkaz:
https://doaj.org/article/0074c10b0715470d9cccd82434924638
Autor:
Angelina Huseinovic, Jolanda S van Leeuwen, Tibor van Welsem, Iris Stulemeijer, Fred van Leeuwen, Nico P E Vermeulen, Jan M Kooter, J Chris Vos
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173573 (2017)
Acetaminophen (APAP), although considered a safe drug, is one of the major causes of acute liver failure by overdose, and therapeutic chronic use can cause serious health problems. Although the reactive APAP metabolite N-acetyl-p-benzoquinoneimine (N
Externí odkaz:
https://doaj.org/article/65f73057d6b14542bc67ed34df520912
Autor:
Hanneke Vlaming, Thom M Molenaar, Tibor van Welsem, Deepani W Poramba-Liyanage, Desiree E Smith, Arno Velds, Liesbeth Hoekman, Tessy Korthout, Sjoerd Hendriks, AF Maarten Altelaar, Fred van Leeuwen
Publikováno v:
eLife, Vol 5 (2016)
Given the frequent misregulation of chromatin in cancer, it is important to understand the cellular mechanisms that regulate chromatin structure. However, systematic screening for epigenetic regulators is challenging and often relies on laborious ass
Externí odkaz:
https://doaj.org/article/e595d7f77f3849ec8660431a9e2c8ef7
Autor:
Rohith Srivas, Thomas Costelloe, Anne-Ruxandra Carvunis, Sovan Sarkar, Erik Malta, Su Ming Sun, Marijke Pool, Katherine Licon, Tibor van Welsem, Fred van Leeuwen, Peter J. McHugh, Haico van Attikum, Trey Ideker
Publikováno v:
Cell Reports, Vol 5, Iss 6, Pp 1714-1724 (2013)
Efficient repair of UV-induced DNA damage requires the precise coordination of nucleotide excision repair (NER) with numerous other biological processes. To map this crosstalk, we generated a differential genetic interaction map centered on quantitat
Externí odkaz:
https://doaj.org/article/49b48a24b019447baf1e06106fc31587
Autor:
Marta Radman-Livaja, Tiffani K Quan, Lourdes Valenzuela, Jennifer A Armstrong, Tibor van Welsem, Taesoo Kim, Laura J Lee, Stephen Buratowski, Fred van Leeuwen, Oliver J Rando, Grant A Hartzog
Publikováno v:
PLoS Genetics, Vol 8, Iss 7, p e1002811 (2012)
Chd proteins are ATP-dependent chromatin remodeling enzymes implicated in biological functions from transcriptional elongation to control of pluripotency. Previous studies of the Chd1 subclass of these proteins have implicated them in diverse roles i
Externí odkaz:
https://doaj.org/article/4618d4ff39504e22860d8deb0e6a7b99
Autor:
Kitty F Verzijlbergen, Tibor van Welsem, Daoud Sie, Tineke L Lenstra, Daniel J Turner, Frank C P Holstege, Ron M Kerkhoven, Fred van Leeuwen
Publikováno v:
PLoS Genetics, Vol 7, Iss 10, p e1002284 (2011)
Dynamic modification of histone proteins plays a key role in regulating gene expression. However, histones themselves can also be dynamic, which potentially affects the stability of histone modifications. To determine the molecular mechanisms of hist
Externí odkaz:
https://doaj.org/article/e7e59b7e85a54af4b17fe35c1b0128fc
Autor:
Marta Radman-Livaja, Kitty F Verzijlbergen, Assaf Weiner, Tibor van Welsem, Nir Friedman, Oliver J Rando, Fred van Leeuwen
Publikováno v:
PLoS Biology, Vol 9, Iss 6, p e1001075 (2011)
Replicating chromatin involves disruption of histone-DNA contacts and subsequent reassembly of maternal histones on the new daughter genomes. In bulk, maternal histones are randomly segregated to the two daughters, but little is known about the fine
Externí odkaz:
https://doaj.org/article/fc8a3089d93c44dfa5a53977e984c948
Autor:
Maria Elize van Breugel, Ila van Kruijsbergen, Chitvan Mittal, Cor Lieftink, Ineke Brouwer, Teun van den Brand, Roelof J.C. Kluin, Renée Menezes, Tibor van Welsem, Andrea Del Cortona, Muddassir Malik, Roderick Beijersbergen, Tineke L. Lenstra, Kevin Verstrepen, B. Franklin Pugh, Fred van Leeuwen
Transcription of tRNA genes by RNA Polymerase III (RNAPIII) is tightly regulated by signaling cascades in response to nutrient availability. The emerging notion of differential tRNA gene regulation implies the existence of additional regulatory mecha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::450e3afa694379345ae6e5cb84f4831f
https://doi.org/10.1101/2023.04.17.534528
https://doi.org/10.1101/2023.04.17.534528