Zobrazeno 1 - 10
of 151
pro vyhledávání: '"Tibor Rohacs"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Mechanosensitive PIEZO2 ion channels play roles in touch, proprioception, and inflammatory pain. Currently, there are no small molecule inhibitors that selectively inhibit PIEZO2 over PIEZO1. The TMEM120A protein was shown to inhibit PIEZO2
Externí odkaz:
https://doaj.org/article/4ee9d394b91046eea2d8b6cd0bf1f855
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Long-chain acyl-coenzyme A (LC-CoA) is a crucial metabolic intermediate that plays important cellular regulatory roles, including activation and inhibition of ion channels. The structural basis of ion channel regulation by LC-CoA is not know
Externí odkaz:
https://doaj.org/article/7b49199ee6fa4018b14432c414d392b3
Autor:
Matthew Gabrielle, Tibor Rohacs
Publikováno v:
Channels, Vol 17, Iss 1 (2023)
ABSTRACTTMEM120A (TACAN) is an enigmatic protein with several seemingly unconnected functions. It was proposed to be an ion channel involved in sensing mechanical stimuli, and knockdown/knockout experiments have implicated that TMEM120A may be necess
Externí odkaz:
https://doaj.org/article/52eee9126e3d43f18a04d2bf2e00d363
Autor:
Lydie Burglen, Evelien Van Hoeymissen, Leila Qebibo, Magalie Barth, Newell Belnap, Felix Boschann, Christel Depienne, Katrien De Clercq, Andrew GL Douglas, Mark P Fitzgerald, Nicola Foulds, Catherine Garel, Ingo Helbig, Katharina Held, Denise Horn, Annelies Janssen, Angela M Kaindl, Vinodh Narayanan, Christina Prager, Mailys Rupin-Mas, Alexandra Afenjar, Siyuan Zhao, Vincent Th Ramaekers, Sarah M Ruggiero, Simon Thomas, Stéphanie Valence, Lionel Van Maldergem, Tibor Rohacs, Diana Rodriguez, David Dyment, Thomas Voets, Joris Vriens
Publikováno v:
eLife, Vol 12 (2023)
TRPM3 is a temperature- and neurosteroid-sensitive plasma membrane cation channel expressed in a variety of neuronal and non-neuronal cells. Recently, rare de novo variants in TRPM3 were identified in individuals with developmental and epileptic ence
Externí odkaz:
https://doaj.org/article/40dfdc180e96470192bccc762e052743
Autor:
Wenjuan Jiang, John Smith Del Rosario, Wesley Botello-Smith, Siyuan Zhao, Yi-chun Lin, Han Zhang, Jérôme Lacroix, Tibor Rohacs, Yun Lyna Luo
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Mechanosensitive Piezo1 channels transduce mechanical stimuli into electrochemical signals. Jiang et al. show that due to the bending rigidity of the membrane, the overlap of neighboring Piezo1 footprints produces a flattening of the Piezo1 footprint
Externí odkaz:
https://doaj.org/article/260f5ac2fa9043ccbe7d6be853d3c43f
Publikováno v:
eLife, Vol 9 (2020)
Transient Receptor Potential Melastatin 3 (TRPM3) is a Ca2+ permeable non-selective cation channel activated by heat and chemical agonists such as pregnenolone sulfate and CIM0216. TRPM3 mutations in humans were recently reported to be associated wit
Externí odkaz:
https://doaj.org/article/755e702f625d43f7834d06532b971fa8
Autor:
Taylor E. T. Hughes, Ruth A. Pumroy, Aysenur Torun Yazici, Marina A. Kasimova, Edwin C. Fluck, Kevin W. Huynh, Amrita Samanta, Sudheer K. Molugu, Z. Hong Zhou, Vincenzo Carnevale, Tibor Rohacs, Vera Y. Moiseenkova-Bell
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
TRPV5 is a kidney specific transient receptor potential (TRP) channel with an important role in calcium reabsorption. Here the authors provide mechanistic insights into TRPV5 modulation by determining the phosphatidylinositol 4,5-bisphosphate and cal
Externí odkaz:
https://doaj.org/article/395ce27b94e54cfa86305f1955b2fe21
Autor:
Taylor ET Hughes, John Smith Del Rosario, Abhijeet Kapoor, Aysenur Torun Yazici, Yevgen Yudin, Edwin C Fluck III, Marta Filizola, Tibor Rohacs, Vera Y Moiseenkova-Bell
Publikováno v:
eLife, Vol 8 (2019)
Transient receptor potential vanilloid 5 (TRPV5) is a highly calcium selective ion channel that acts as the rate-limiting step of calcium reabsorption in the kidney. The lack of potent, specific modulators of TRPV5 has limited the ability to probe th
Externí odkaz:
https://doaj.org/article/a82f5f6720e94648810a1aa64e4d1450
Autor:
Ruth A Pumroy, Amrita Samanta, Yuhang Liu, Taylor ET Hughes, Siyuan Zhao, Yevgen Yudin, Tibor Rohacs, Seungil Han, Vera Y Moiseenkova-Bell
Publikováno v:
eLife, Vol 8 (2019)
Transient receptor potential vanilloid 2 (TRPV2) plays a critical role in neuronal development, cardiac function, immunity, and cancer. Cannabidiol (CBD), the non-psychotropic therapeutically active ingredient of Cannabis sativa, is an activator of T
Externí odkaz:
https://doaj.org/article/52c5f3354b914f85a92f15afe3f9c2f4
Autor:
Doreen Badheka, Yevgen Yudin, Istvan Borbiro, Cassandra M Hartle, Aysenur Yazici, Tooraj Mirshahi, Tibor Rohacs
Publikováno v:
eLife, Vol 6 (2017)
Transient receptor potential melastatin 3 (TRPM3) channels are activated by heat, and chemical ligands such as pregnenolone sulphate (PregS) and CIM0216. Here, we show that activation of receptors coupled to heterotrimeric Gi/o proteins inhibits TRPM
Externí odkaz:
https://doaj.org/article/36cbe4af6ef947a09f96415068432824