Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Tibor Kristian"'
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S593- (2023)
Externí odkaz:
https://doaj.org/article/6377ebb2c55847659f7d6d09dd274760
Autor:
Krish Chandrasekaran, Neda Najimi, Avinash R. Sagi, Sushuma Yarlagadda, Mohammad Salimian, Muhammed Ikbal Arvas, Ahmad F. Hedayat, Yanni Kevas, Anand Kadakia, Tibor Kristian, James W. Russell
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 1102 (2024)
Abnormal NAD+ signaling has been implicated in axonal degeneration in diabetic peripheral neuropathy (DPN). We hypothesized that supplementing NAD+ precursors could alleviate DPN symptoms through increasing the NAD+ levels and activating the sirtuin-
Externí odkaz:
https://doaj.org/article/a1276f937c504573a77b0d2abdc6db37
Publikováno v:
Cells, Vol 12, Iss 9, p 1329 (2023)
The mitochondrion has a unique position among other cellular organelles due to its dynamic properties and symbiotic nature, which is reflected in an active exchange of metabolites and cofactors between the rest of the intracellular compartments. The
Externí odkaz:
https://doaj.org/article/b61f6a96c82f4f2b82a8531165e31347
Publikováno v:
Cells, Vol 10, Iss 11, p 3031 (2021)
Mitochondria are a unique intracellular organelle due to their evolutionary origin and multifunctional role in overall cellular physiology and pathophysiology. To meet the specific spatial metabolic demands within the cell, mitochondria are actively
Externí odkaz:
https://doaj.org/article/3bf7250e26d9477ca2981d5b5f5f88f2
Publikováno v:
Cells, Vol 10, Iss 9, p 2348 (2021)
Acetylation is a post-translational modification that regulates the activity of enzymes fundamentally involved in cellular and mitochondrial bioenergetic metabolism. NAD+ dependent deacetylase sirtuin 3 (SIRT3) is localized to mitochondria where it p
Externí odkaz:
https://doaj.org/article/bc04f0146fdb4484a95483b0c4ba56a2
Publikováno v:
Neurobiology of Disease, Vol 95, Iss , Pp 102-110 (2016)
Nicotinamide adenine dinucleotide (NAD+) is an essential cofactor for multiple cellular metabolic reactions and has a central role in energy production. Brain ischemia depletes NAD+ pools leading to bioenergetics failure and cell death. Nicotinamide
Externí odkaz:
https://doaj.org/article/7e6498f3b44a4fe9a40c6cf1447e1370
Publikováno v:
Brain Sciences, Vol 10, Iss 7, p 449 (2020)
It is commonly accepted that mitochondria represent a major source of free radicals following acute brain injury or during the progression of neurodegenerative diseases. The levels of reactive oxygen species (ROS) in cells are determined by two oppos
Externí odkaz:
https://doaj.org/article/f6a03f7743554d24b253c462329d2c47
Autor:
Krish Chandrasekaran, Joungil Choi, Muhammed Ikbal Arvas, Mohammad Salimian, Sujal Singh, Su Xu, Rao P Gullapalli, Tibor Kristian, James William Russell
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 11, p 3756 (2020)
Diabetes predisposes to cognitive decline leading to dementia and is associated with decreased brain NAD+ levels. This has triggered an intense interest in boosting nicotinamide adenine dinucleotide (NAD+) levels to prevent dementia. We tested if the
Externí odkaz:
https://doaj.org/article/613d15938f4841c2934eb5e5e18ed31c
Autor:
Jennifer O’Brien, Peter Niehaus, Juliana Remark, Mohammad Salimian, Yanni Kevas, Samuel Rubin, Tibor Kristian, Krish Chandrasekaran, Catherine Pei-Ju Lu, James W. Russell, Cheng-Ying Ho
Publikováno v:
bioRxiv
Diabetic neuropathy (DN) is a debilitating disorder characterized by mechanical allodynia and sensory loss. It has traditionally been considered a small-fiber neuropathy, defined by the loss of free nerve endings in the epidermis. Free nerve endings,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54cc970df06af3ab9202622846be881a
https://doi.org/10.1101/2023.01.24.523981
https://doi.org/10.1101/2023.01.24.523981
Autor:
Daniil Sokolov, Neha Sharda, Banabihari Giri, Md Sazzad Hassan, Damandeep Singh, Agnieszka Tarasiewicz, Charity Lohr, Urs von Holzen, Tibor Kristian, Jaylyn Waddell, Russel J. Reiter, Hafiz Ahmed, Aditi Banerjee
Publikováno v:
Journal of pineal research. 73(1)
β-catenin signaling, and angiogenesis are associated with colospheroid (CSC), development. CSCs, spheroids derived from colon cancer cells, are responsible for metastasis, drug resistance, and disease recurrence. Whether dysregulating β-catenin and