Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Tibor Hornyik"'
Autor:
Aiman Saleh A. Mohammed, Muhammad Naveed, Tamara Szabados, István Szatmári, Bálint Lőrinczi, Péter Mátyus, Andrea Czompa, Péter Orvos, Zoltán Husti, Tibor Hornyik, Leila Topal, Szilvia Déri, Norbert Jost, László Virág, Péter Bencsik, István Baczkó, András Varró
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract The antiarrhythmic and cardiac electrophysiological effects of SZV-2649 that contains a 2,6-diiodophenoxy moiety but lacks the benzofuran ring system present in amiodarone, were studied in mammalian cell line, rat and dog cardiac preparation
Externí odkaz:
https://doaj.org/article/5d4fa82f0b174061a914887e2d1f4166
Autor:
Paul Kreifels, Ilona Bodi, Tibor Hornyik, Gerlind Franke, Stefanie Perez-Feliz, R. Lewetag, Robin Moss, Alessandro Castiglione, David Ziupa, Manfred Zehender, Michael Brunner, Christoph Bode, Katja E. Odening
Publikováno v:
International Journal of Cardiology: Heart & Vasculature, Vol 40, Iss , Pp 101001- (2022)
Background: Oxytocin is used therapeutically in psychiatric patients. Many of these also receive anti-depressant or anti-psychotic drugs causing acquired long-QT-syndrome (LQTS) by blocking HERG/IKr. We previously identified an oxytocin-induced QT-pr
Externí odkaz:
https://doaj.org/article/99c765bb8d1541cea0dea16bce4c491e
Autor:
Robin Moss, Eike M Wülfers, Raphaela Lewetag, Tibor Hornyik, Stefanie Perez-Feliz, Tim Strohbach, Marius Menza, Axel Krafft, Katja E Odening, Gunnar Seemann
Publikováno v:
PLoS ONE, Vol 17, Iss 6, p e0270559 (2022)
Computational modeling of electrophysiological properties of the rabbit heart is a commonly used way to enhance and/or complement findings from classic lab work on single cell or tissue levels. Yet, thus far, there was no possibility to extend the sc
Externí odkaz:
https://doaj.org/article/07502221af654144a1c1795e2e1ac866
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Drug-induced proarrhythmia constitutes a potentially lethal side effect of various drugs. Most often, this proarrhythmia is mechanistically linked to the drug's potential to interact with repolarizing cardiac ion channels causing a prolongation of th
Externí odkaz:
https://doaj.org/article/e5cd981baf684617851bcb899fbd64c5
Autor:
Zsófia Kohajda, Nikolett Farkas-Morvay, Norbert Jost, Norbert Nagy, Amir Geramipour, András Horváth, Richárd S Varga, Tibor Hornyik, Claudia Corici, Károly Acsai, Balázs Horváth, János Prorok, Balázs Ördög, Szilvia Déri, Dániel Tóth, Jouko Levijoki, Piero Pollesello, Tuula Koskelainen, Leena Otsomaa, András Tóth, István Baczkó, István Leprán, Péter P Nánási, Julius Gy Papp, András Varró, László Virág
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0166041 (2016)
In this study the effects of a new, highly selective sodium-calcium exchanger (NCX) inhibitor, ORM-10962 were investigated on cardiac NCX current, Ca2+ transients, cell shortening and in experimental arrhythmias. The level of selectivity of the novel
Externí odkaz:
https://doaj.org/article/61d59a8ac797493b98a5af678d4d4f1a
Autor:
Zsófia Kohajda, László Virág, Tibor Hornyik, Zoltán Husti, Anita Sztojkov‐Ivanov, Norbert Nagy, András Horváth, Richárd Varga, János Prorok, Jozefina Szlovák, Noémi Tóth, Péter Gazdag, Leila Topal, Muhammad Naveed, Tamás Árpádffy‐Lovas, Bence Pászti, Tibor Magyar, István Koncz, Szilvia Déri, Vivien Demeter‐Haludka, Zoltán Aigner, Balázs Ördög, Márta Patfalusi, László Tálosi, László Tiszlavicz, Imre Földesi, Norbert Jost, István Baczkó, András Varró
Publikováno v:
British Journal of Pharmacology. 179:3382-3402
The aim of the present study was to study the antiarrhythmic effects and cellular mechanisms of desethylamiodarone (DEA), the main metabolite of amiodarone (AMIO), following acute and chronic 4-week oral treatments (25-50 mg·kgThe antiarrhythmic eff
Autor:
Jessica J Jowais, Marina Rieder, Lucilla Giammarino, Katja E. Odening, Michael Brunner, Christoph Bode, Sara I. Liin, Alessandro Castiglione, Manfred Zehender, Stefanie Perez-Feliz, Eike M. Wülfers, Gideon Koren, Hans Peter Larsson, Tibor Hornyik, István Baczkó, Iask Edler, András Varró, Zsuzsanna Bősze
Publikováno v:
Europace
Aim Long QT syndrome (LQTS) is a cardiac channelopathy predisposing to ventricular arrhythmias and sudden cardiac death. Since current therapies often fail to prevent arrhythmic events in certain LQTS subtypes, new therapeutic strategies are needed.
Autor:
Tibor Hornyik
Proarrhythmia - the triggering of arrhythmias following drug therapy - is a rare, but potentially lethal side-effect of various drugs, and therefore, a major safety concern during drug development. Most often proarrhythmia is caused by the drugs’ p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ad9cc1b2fae28aade5fc7c2a4711a2b
https://doi.org/10.14232/phd.10811
https://doi.org/10.14232/phd.10811
Autor:
Gideon Koren, Marina Rieder, Katja E. Odening, Alessandro Castiglione, Tibor Hornyik, István Baczkó, Michael Brunner, P. Major
Publikováno v:
British journal of pharmacologyREFERENCES. 179(5)
To study the pathophysiology of human cardiac diseases and to develop novel treatment strategies, complex interactions of cardiac cells on cellular, tissue and on level of the whole heart need to be considered. As in vitro cell-based models do not de
Autor:
András Varró, Prof.Dr. Péter Mátyus, Gábor Krajsovszky, Tibor Hornyik, István Baczkó, László Virág, László Tálosi, Richárd S. Varga, Zoltán Husti, Norbert Nagy, Zsófia Kohajda, Norbert Jost
Publikováno v:
Canadian journal of physiology and pharmacology. 99(1)
Cardiovascular diseases are the leading causes of mortality. Sudden cardiac death is most commonly caused by ventricular fibrillation (VF). Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and a major cause of stroke and heart