Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Tibisay, Guevara"'
Autor:
Danuta Mizgalska, Arturo Rodríguez-Banqueri, Florian Veillard, Mirosław Książęk, Theodoros Goulas, Tibisay Guevara, Ulrich Eckhard, Jan Potempa, F. Xavier Gomis-Rüth
Publikováno v:
Open Biology, Vol 14, Iss 6 (2024)
Gram-negative bacteria from the Bacteroidota phylum possess a type-IX secretion system (T9SS) for protein secretion, which requires cargoes to have a C-terminal domain (CTD). Structurally analysed CTDs are from Porphyromonas gingivalis proteins RgpB,
Externí odkaz:
https://doaj.org/article/ad1a5dec84394926a6901eee7856ddc6
Autor:
Tamuka M. Chidyausiku, Soraia R. Mendes, Jason C. Klima, Marta Nadal, Ulrich Eckhard, Jorge Roel-Touris, Scott Houliston, Tibisay Guevara, Hugh K. Haddox, Adam Moyer, Cheryl H. Arrowsmith, F. Xavier Gomis-Rüth, David Baker, Enrique Marcos
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
The immunoglobulin domain framework of antibodies has been a long standing design challenge. Here, the authors describe design rules for tailoring these domains and show they can be accurately designed, de novo, with high stability and the ability to
Externí odkaz:
https://doaj.org/article/97a8dd6f14d04e56ae09b84b09e5515d
Autor:
Laura del Amo-Maestro, Soraia R. Mendes, Arturo Rodríguez-Banqueri, Laura Garzon-Flores, Marina Girbal, María José Rodríguez-Lagunas, Tibisay Guevara, Àngels Franch, Francisco J. Pérez-Cano, Ulrich Eckhard, F. Xavier Gomis-Rüth
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Celiac disease is characterized by intolerance to gluten, a cereal protein. Here, the authors show that neprosin, a glutamate peptidase from the pitcher plant, efficiently cleaves gluten components under physiological conditions in vitro and in the g
Externí odkaz:
https://doaj.org/article/c97bf5c69b2542dc92e0df34d7aecee1
Autor:
Soraia R. Mendes, Ulrich Eckhard, Arturo Rodríguez-Banqueri, Tibisay Guevara, Peter Czermak, Enrique Marcos, Andreas Vilcinskas, F. Xavier Gomis-Rüth
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 534-544 (2022)
Aureolysin, a secreted metallopeptidase (MP) from the thermolysin family, functions as a major virulence factor in Staphylococcus aureus. No specific aureolysin inhibitors have yet been described, making this an important target for the development o
Externí odkaz:
https://doaj.org/article/1e0c32ae4f5848d6a20d93f2fff9494e
Autor:
Tibisay Guevara, Arturo Rodriguez-Banqueri, Miroslaw Ksiazek, Jan Potempa, F. Xavier Gomis-Rüth
Publikováno v:
IUCrJ, Vol 7, Iss 1, Pp 18-29 (2020)
Tannerella forsythia is an oral dysbiotic periodontopathogen involved in severe human periodontal disease. As part of its virulence factor armamentarium, at the site of colonization it secretes mirolysin, a metallopeptidase of the unicellular pappaly
Externí odkaz:
https://doaj.org/article/25296af507af4334ad354c0e4cb88394
Autor:
Anna Cuppari, Hagen Körschgen, Dirk Fahrenkamp, Carlo Schmitz, Tibisay Guevara, Konstantin Karmilin, Michael Kuske, Mario Olf, Eileen Dietzel, Irene Yiallouros, Daniele de Sanctis, Theodoros Goulas, Ralf Weiskirchen, Willi Jahnen-Dechent, Julia Floehr, Walter Stoecker, Luca Jovine, F. Xavier Gomis-Rüth
Publikováno v:
IUCrJ, Vol 6, Iss 2, Pp 317-330 (2019)
Mammalian fetuin-A and fetuin-B are abundant serum proteins with pleiotropic functions. Fetuin-B is a highly selective and potent inhibitor of metallopeptidases (MPs) of the astacin family, which includes ovastacin in mammals. By inhibiting ovastacin
Externí odkaz:
https://doaj.org/article/24d7abbd57094fd4a8c4d4c291760b72
Autor:
Arturo Rodríguez-Banqueri, Marina Moliner-Culubret, Soraia R. Mendes, Tibisay Guevara, Ulrich Eckhard, F. Xavier Gomis-Rüth
Publikováno v:
Dalton Transactions. 52:3610-3622
The metallopeptidase ulilysin is kept latent by a cysteine-switch mechanism and is unexpectedly inhibited by the serine-peptidase inhibitor, 4-(2-aminoethyl)benzenesulfonyl fluoride.
Autor:
Mirosław Książek, Theodoros Goulas, Danuta Mizgalska, Arturo Rodríguez-Banqueri, Ulrich Eckhard, Florian Veillard, Irena Waligórska, Małgorzata Benedyk-Machaczka, Alicja M. Sochaj-Gregorczyk, Mariusz Madej, Ida B. Thøgersen, Jan J. Enghild, Anna Cuppari, Joan L. Arolas, Iñaki de Diego, Mar López-Pelegrín, Irene Garcia-Ferrer, Tibisay Guevara, Vincent Dive, Marie-Louise Zani, Thierry Moreau, Jan Potempa, F. Xavier Gomis-Rüth
Publikováno v:
Chemical Science
Chemical Science, 2023, 14 (4), pp.869-888. ⟨10.1039/d2sc04166a⟩
Książek, M, Goulas, T, Mizgalska, D, Rodríguez-Banqueri, A, Eckhard, U, Veillard, F, Waligórska, I, Benedyk-Machaczka, M, Sochaj-Gregorczyk, A M, Madej, M, Thøgersen, I B, Enghild, J J, Cuppari, A, Arolas, J L, de Diego, I, López-Pelegrín, M, Garcia-Ferrer, I, Guevara, T, Dive, V, Zani, M L, Moreau, T, Potempa, J & Gomis-Rüth, F X 2023, ' A unique network of attack, defence and competence on the outer membrane of the periodontitis pathogen Tannerella forsythia ', Chemical Science, vol. 14, no. 4, pp. 869-888 . https://doi.org/10.1039/d2sc04166a
Chemical Science, 2023, 14 (4), pp.869-888. ⟨10.1039/d2sc04166a⟩
Książek, M, Goulas, T, Mizgalska, D, Rodríguez-Banqueri, A, Eckhard, U, Veillard, F, Waligórska, I, Benedyk-Machaczka, M, Sochaj-Gregorczyk, A M, Madej, M, Thøgersen, I B, Enghild, J J, Cuppari, A, Arolas, J L, de Diego, I, López-Pelegrín, M, Garcia-Ferrer, I, Guevara, T, Dive, V, Zani, M L, Moreau, T, Potempa, J & Gomis-Rüth, F X 2023, ' A unique network of attack, defence and competence on the outer membrane of the periodontitis pathogen Tannerella forsythia ', Chemical Science, vol. 14, no. 4, pp. 869-888 . https://doi.org/10.1039/d2sc04166a
Periodontopathogenic Tannerella forsythia uniquely secretes six peptidases of disparate catalytic classes and families that operate as virulence factors during infection of the gums, the KLIKK-peptidases. Their coding genes are immediately downstream
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7698e6876d479a7bef16c93ae86818e9
https://ruj.uj.edu.pl/xmlui/handle/item/308078
https://ruj.uj.edu.pl/xmlui/handle/item/308078
Autor:
Ana Jimenez‐Alesanco, Ulrich Eckhard, Marta Asencio del Rio, Sonia Vega, Tibisay Guevara, Adrian Velazquez‐Campoy, Francesc Xavier Gomis‐Rüth, Olga Abian
Bacteroides fragilis is an abundant commensal component of the healthy human colon. However, under dysbiotic conditions, enterotoxigenic B. fragilis (ETBF) may arise and elicit diarrhea, anaerobic bacteremia, inflammatory bowel disease, and colorecta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e534a972551c53b55b3cb913fa450bc8
http://hdl.handle.net/10261/288530
http://hdl.handle.net/10261/288530
Autor:
Tibisay Guevara, Arturo Rodríguez-Banqueri, Walter Stöcker, Christoph Becker-Pauly, F. Xavier Gomis-Rüth
Publikováno v:
Acta crystallographica. Section D, Structural biology. 78(Pt 11)
The horseshoe crab Limulus polyphemus is one of few extant Limulus species, which date back to ∼250 million years ago under the conservation of a common Bauplan documented by fossil records. It possesses the only proteolytic blood-coagulation and i