Identification of novel glucocerebrosidase chaperones by unexpected skeletal rearrangement reaction.

Autor: Takeda K; Hatfield Research Laboratories, Eisai Ltd., Hatfield AL10 9SN, United Kingdom., Watanabe T; Hatfield Research Laboratories, Eisai Ltd., Hatfield AL10 9SN, United Kingdom., Smith JR; Charles River Laboratories, 7-9 Spire Green Centre, Flex Meadow, Harlow, Essex CM19 5TR, United Kingdom., Vesey D; Charles River Laboratories, 7-9 Spire Green Centre, Flex Meadow, Harlow, Essex CM19 5TR, United Kingdom., Tiberghien N; Charles River Laboratories, 7-9 Spire Green Centre, Flex Meadow, Harlow, Essex CM19 5TR, United Kingdom., Lewis S; Hatfield Research Laboratories, Eisai Ltd., Hatfield AL10 9SN, United Kingdom., Powney B; Hatfield Research Laboratories, Eisai Ltd., Hatfield AL10 9SN, United Kingdom., Schapira AHV; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom., Hoshikawa T; Hatfield Research Laboratories, Eisai Ltd., Hatfield AL10 9SN, United Kingdom. Electronic address: t-hoshikawa@hhc.eisai.co.jp., Takle AK; Hatfield Research Laboratories, Eisai Ltd., Hatfield AL10 9SN, United Kingdom.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2023 Nov 15; Vol. 96, pp. 129531. Date of Electronic Publication: 2023 Oct 20.

Assessment of changes in intra-abdominal pressure and cardiac output induced by liver compression in healthy anesthetized spontaneously breathing dogs.

Autor: Seo, Daeyun¹ (AUTHOR), Lim, Seongsoo¹ (AUTHOR), Namgoong, Beomkwan¹ (AUTHOR), Uhm, Heesung¹ (AUTHOR), Hong, Hyeajeong¹ (AUTHOR), Lee, Nanju¹ (AUTHOR), Kim, Isong¹ (AUTHOR), Heo, Seunghun¹ (AUTHOR), Kang, Ji Hwan¹ (AUTHOR), Kim, Cheyoun¹ (AUTHOR), Shin, Hayoung¹ (AUTHOR), Her, Jiwoong² (AUTHOR), Kim, Min Su¹ (AUTHOR) minsukim@snu.ac.kr

Publikováno v: PLoS ONE. 12/12/2024, Vol. 19 Issue 12, p1-14. 14p.

Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis.

Autor: Walker AL; Discovery Partnerships with Academia, GlaxoSmithKline , Gunnels Wood Road, Stevenage SG1 2NY, UK., Ancellin N; Flexible Discovery Unit, GlaxoSmithKline , Paris, France., Beaufils B; Flexible Discovery Unit, GlaxoSmithKline , Paris, France., Bergeal M; Platform Technology Sciences, GlaxoSmithKline Stevenage SG1 2NY, UK., Binnie M; Centre for Cardiovascular Science, University of Edinburgh , Edinburgh EH16 4TJ, UK., Bouillot A; Flexible Discovery Unit, GlaxoSmithKline , Paris, France., Clapham D; Platform Technology Sciences, GlaxoSmithKline Stevenage SG1 2NY, UK., Denis A; Flexible Discovery Unit, GlaxoSmithKline , Paris, France., Haslam CP; Platform Technology Sciences, GlaxoSmithKline Stevenage SG1 2NY, UK., Holmes DS; Discovery Partnerships with Academia, GlaxoSmithKline , Gunnels Wood Road, Stevenage SG1 2NY, UK., Hutchinson JP; Platform Technology Sciences, GlaxoSmithKline Stevenage SG1 2NY, UK., Liddle J; Discovery Partnerships with Academia, GlaxoSmithKline , Gunnels Wood Road, Stevenage SG1 2NY, UK., McBride A; Centre for Cardiovascular Science, University of Edinburgh , Edinburgh EH16 4TJ, UK., Mirguet O; Flexible Discovery Unit, GlaxoSmithKline , Paris, France., Mowat CG; EastChem School of Chemistry, University of Edinburgh , Edinburgh EH9 3FJ, UK., Rowland P; Platform Technology Sciences, GlaxoSmithKline Stevenage SG1 2NY, UK., Tiberghien N; Flexible Discovery Unit, GlaxoSmithKline , Paris, France., Trottet L; Flexible Discovery Unit, GlaxoSmithKline , Paris, France., Uings I; Discovery Partnerships with Academia, GlaxoSmithKline , Gunnels Wood Road, Stevenage SG1 2NY, UK., Webster SP; Centre for Cardiovascular Science, University of Edinburgh , Edinburgh EH16 4TJ, UK., Zheng X; MRC Centre for Inflammation Research, University of Edinburgh , Edinburgh EH16 4TJ, UK., Mole DJ; MRC Centre for Inflammation Research, University of Edinburgh , Edinburgh EH16 4TJ, UK.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2017 Apr 27; Vol. 60 (8), pp. 3383-3404. Date of Electronic Publication: 2017 Apr 11.

Prediction of fluid responsiveness following liver compression in pediatric patients with single ventricle physiology.

Autor: Lee, Ji‐Hyun¹ (AUTHOR), Jang, Hwan‐Suk¹ (AUTHOR), Kang, Pyoyoon¹ (AUTHOR), Song, In Sun¹ (AUTHOR), Ji, Sang‐Hwan¹ (AUTHOR), Jang, Young‐Eun¹ (AUTHOR), Kim, Eun‐Hee¹ (AUTHOR), Kim, Hee‐Soo¹ (AUTHOR), Kim, Jin‐Tae¹ (AUTHOR) jintae73@snu.ac.kr

Publikováno v: Pediatric Anesthesia. May2022, Vol. 32 Issue 5, p637-646. 10p.

Chemical technology principles for selective bioconjugation of proteins and antibodies.

Autor: Chauhan, Preeti, V., Ragendu, Kumar, Mohan, Molla, Rajib, Mishra, Surya Dev, Basa, Sneha, Rai, Vishal

Publikováno v: Chemical Society Reviews; 1/7/2024, Vol. 53 Issue 1, p380-449, 70p