Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Tiara T. Byrd"'
Autor:
Meenakshi Hegde, Sujith K. Joseph, Farzana Pashankar, Christopher DeRenzo, Khaled Sanber, Shoba Navai, Tiara T. Byrd, John Hicks, Mina L. Xu, Claudia Gerken, Mamta Kalra, Catherine Robertson, Huimin Zhang, Ankita Shree, Birju Mehta, Olga Dakhova, Vita S. Salsman, Bambi Grilley, Adrian Gee, Gianpietro Dotti, Helen E. Heslop, Malcolm K. Brenner, Winfried S. Wels, Stephen Gottschalk, Nabil Ahmed
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Recurrent metastatic rhabdomyosarcoma remains largely incurable. Here, the authors describe a child with metastatic rhabdomyosarcoma who has durable response to HER2-specific CAR T cells and shows endogenous immune reactivity.
Externí odkaz:
https://doaj.org/article/924e95c7aec9406f9a123abaaaf5e1e2
Autor:
Nabil Ahmed, Brad St. Croix, Bradley S. Fletcher, Meenakshi Hegde, Michael T. Lewis, Matthew J. Ellis, Benjamin Deneen, Poul H. Sorensen, Joachim Koch, Winfried S. Wels, Matthew L. Baker, Suzanne Powell, John Hicks, Nino Rainusso, Daniel Landi, Kevin Bielamowicz, Htoo Zarni Oo, Vita S. Salsman, Lacey Dobrolecki, Steven Seaman, Heba Samaha, Christopher Szot, Antonella Pignata, Kristen Fousek, Tiara T. Byrd
Information about methods and data that further support the claims made in this article. This includes, but is not limited to TEM8 distribution in normal tissues, CAR T cell normalization, additional control groups and CAR toxicity studies.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::059c2ab76dcfed3e611890416f8bbef3
https://doi.org/10.1158/0008-5472.22417994.v1
https://doi.org/10.1158/0008-5472.22417994.v1
Autor:
Nabil Ahmed, Brad St. Croix, Bradley S. Fletcher, Meenakshi Hegde, Michael T. Lewis, Matthew J. Ellis, Benjamin Deneen, Poul H. Sorensen, Joachim Koch, Winfried S. Wels, Matthew L. Baker, Suzanne Powell, John Hicks, Nino Rainusso, Daniel Landi, Kevin Bielamowicz, Htoo Zarni Oo, Vita S. Salsman, Lacey Dobrolecki, Steven Seaman, Heba Samaha, Christopher Szot, Antonella Pignata, Kristen Fousek, Tiara T. Byrd
L2 2G and L2 3G CAR T cell normalization and functional testing.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fe823f256230caf791bf1669207c24e
https://doi.org/10.1158/0008-5472.22418006
https://doi.org/10.1158/0008-5472.22418006
Autor:
Christopher DeRenzo, Stephen Gottschalk, John Hicks, Winfried S. Wels, Catherine Robertson, Tiara T. Byrd, Olga Dakhova, Ankita Shree, Farzana Pashankar, Nabil Ahmed, Khaled Sanber, Gianpietro Dotti, Claudia Gerken, Mina L. Xu, Meenakshi Hegde, Vita S. Salsman, Sujith K. Joseph, Helen E. Heslop, Bambi Grilley, Mamta Kalra, Shoba A. Navai, Malcolm K. Brenner, Adrian P. Gee, Birju Mehta, Huimin Zhang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Refractory metastatic rhabdomyosarcoma is largely incurable. Here we analyze the response of a child with refractory bone marrow metastatic rhabdomyosarcoma to autologous HER2 CAR T cells. Three cycles of HER2 CAR T cells given after lymphodepleting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52ba4621fb359fbc26a85390ff0a183f
https://doi.org/10.1038/s41467-020-17175-8
https://doi.org/10.1038/s41467-020-17175-8
Autor:
Meenakshi Hegde, Jonathan M. Levitt, Colby J. Hofferek, Briana A. Burns, Nabil Ahmed, Yunyu Baig, Tiara T. Byrd, Jonathan Vazquez-Perez, Damilola Oyewole-Said, Dongliang Liu, Zhengdong Liang, Vanaja Konduri, Changyi Chen, Vita S. Salsman, Anna Tsimelzon, Matthew M. Halpert, Sujith K. Joseph, Qizhi Yao, William K. Decker, Zeid Nawas
Publikováno v:
Sci Transl Med
In humans, the NK cell marker CD161 identifies several subsets of T cells, including a polyclonal CD8 αβ T cell receptor expressing subset with characteristic specificity for tissue-localized viruses. This subset has also been reported to display e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::678fa3f46556370fbae0e04c66a3e318
https://pubmed.ncbi.nlm.nih.gov/34079103
https://pubmed.ncbi.nlm.nih.gov/34079103
Autor:
Tiara T. Byrd, Xingyue An, Meenakshi Hegde, Khaled Sanber, Lorenzo Brunetti, Ahmed Z. Gad, Dimitrios L. Wagner, Nabil Ahmed, Yong-Mi Kim, Matthew L. Baker, Albert Jang, Jessica S. Morris, Shoba A. Navai, Nora Heisterkamp, Kristen Fousek, Melisa Martinez-Paniagua, Hisham Abdel-Azim, Vita S. Salsman, Junji Watanabe, Annie Luong, Hye Na Kim, Pretty R. Mathew, Navin Varadarajan, Sujith K. Joseph, Ann George
Publikováno v:
Leukemia
Chimeric antigen receptor (CAR) T-cells targeting CD19 demonstrate remarkable efficacy in treating B-lineage acute lymphoblastic leukemia (BL-ALL), yet up to 39% of treated patients relapse with CD19(−) disease. We report that CD19(−) escape is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2a83be2f192451098fdb6f22d3e2605
http://hdl.handle.net/11391/1464333
http://hdl.handle.net/11391/1464333
Autor:
Vita S. Salsman, Ankita Shree, Tiara T. Byrd, Fabio Stossi, Sujith K. Joseph, Malini Mukherjee, Poul H. Sorensen, Sung-Ha Hong, Jordan S. Orange, Heba Samaha, Shanmugarajan Krishnan, Rakesh K. Jain, Fong Lam, Maksim Mamonkin, Jun Ren, Shahenda El-Naggar, Antonella Pignata, Ahmed Z. Gad, Dai Fukumura, Meenakshi Hegde, Thomas Shum, Matthew L. Baker, Michael D. Taylor, Kristen Fousek, Julien Dubrulle, Nabil Ahmed, Sean P. Marrelli
Publikováno v:
Nature. 561:331-337
Successful T cell immunotherapy for brain cancer requires that the T cells can access tumour tissues, but this has been difficult to achieve. Here we show that, in contrast to inflammatory brain diseases such as multiple sclerosis, where endothelial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c69fc68d010f7127857fa44fe17554f
https://doi.org/10.1038/s41586-018-0499-y
https://doi.org/10.1038/s41586-018-0499-y
Autor:
Dai Fukumura, Matthew L. Baker, Fong Lam, Tiara T. Byrd, Maksim Mamonkin, Michael D. Taylor, Shahenda El-Naggar, Ankita Shree, Antonella Pignata, Nabil Ahmed, Malini Mukherjee, Fabio Stossi, Shanmugarajan Krishnan, Rakesh K. Jain, Sean P. Marrelli, Jordan S. Orange, Ahmed Z. Gad, Jun Ren, Vita S. Salsman, Kristen Fousek, Heba Samaha, Julien Dubrulle, Sujith K. Joseph, Meenakshi Hegde, Poul H. Sorensen, Sung-Ha Hong, Thomas Shum
Publikováno v:
Nature
Successful T cell immunotherapy for brain cancer requires that the T cells can access tumour tissues, but this has been difficult to achieve. Here we show that, in contrast to inflammatory brain diseases such as multiple sclerosis, where endothelial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a1877d1915bf3dfb1ee6d5f7e3cffc0
https://europepmc.org/articles/PMC6497143/
https://europepmc.org/articles/PMC6497143/
Autor:
Antonella Pignata, Meenakshi Hegde, Kevin Bielamowicz, Winfried S. Wels, Nabil Ahmed, Bradley S. Fletcher, Tiara T. Byrd, Daniel Landi, B St Croix, Joachim Koch, Steven Seaman, Christopher S. Szot, Amanda Wakefield, Kristen Fousek
Publikováno v:
Cancer Research. 76:PD3-07
Background: Triple Negative Breast Cancer (TNBC) refers to an aggressive subtype of breast cancer negative for HER2, estrogen and progesterone receptors. Lacking these receptors, individuals with TNBC do not benefit from many of the targeted therapie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bba7a20ec566958315a86b32dd191423
https://doi.org/10.1158/1538-7445.sabcs15-pd3-07
https://doi.org/10.1158/1538-7445.sabcs15-pd3-07
Autor:
Meenakshi Hegde, Tsz-Kwong Man, Kevin Bielamowicz, Pavel Sumazin, Tiara T. Byrd, Sujith K. Joseph, Meng-Fen Wu, Nabil Ahmed, Hebatalla Samaha, Nikita Aware, Malini Mukherjee, Jordan S. Orange, Kristen Fousek
Publikováno v:
J Clin Invest
Background Glioblastoma (GBM) is the most common primary malignant brain cancer, and is currently incurable. Chimeric antigen receptor (CAR) T cells have shown promise in GBM treatment. While we have shown that combinatorial targeting of 2 glioma ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a90bbcf21f4196dde77d9eddd5b7c267
https://pubmed.ncbi.nlm.nih.gov/34196303
https://pubmed.ncbi.nlm.nih.gov/34196303