Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Tianzhu Zang"'
Autor:
Michael H. J. Rhodin, Archie C. Reyes, Anand Balakrishnan, Nalini Bisht, Nicole M. Kelly, Joyce Sweeney Gibbons, Jonathan Lloyd, Michael Vaine, Tessa Cressey, Miranda Crepeau, Ruichao Shen, Nathan Manalo, Jonathan Castillo, Rachel E. Levene, Daniel Leonard, Tianzhu Zang, Lijuan Jiang, Kellye Daniels, Robert M. Cox, Carolin M. Lieber, Josef D. Wolf, Richard K. Plemper, Sarah R. Leist, Trevor Scobey, Ralph S. Baric, Guoqiang Wang, Bryan Goodwin, Yat Sun Or
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract The COVID-19 pandemic has led to the deaths of millions of people and severe global economic impacts. Small molecule therapeutics have played an important role in the fight against SARS-CoV-2, the virus responsible for COVID-19, but their ef
Externí odkaz:
https://doaj.org/article/b18ce07e716a43029667919f23fb41e5
Autor:
Tianzhu Zang, Ligi Paul Pottenplackel, Diane E. Handy, Joseph Loscalzo, Shujia Dai, Richard C. Deth, Zhaohui Sunny Zhou, Jisheng Ma
Publikováno v:
Molecules, Vol 21, Iss 9, p 1195 (2016)
Elevated blood concentrations of homocysteine have been well established as a risk factor for cardiovascular diseases and neuropsychiatric diseases, yet the etiologic relationship of homocysteine to these disorders remains poorly understood. Protein
Externí odkaz:
https://doaj.org/article/ffce14bfaac2403293d74a582dc8c9fa
Autor:
Paul C. Trippier, Trevor M. Penning, Sanjay K. Srivastava, Phumvadee Wangtrakluldee, Tianzhu Zang, Nehal Gupta, Kshitij Verma
Aldo-keto reductase 1C3 (AKR1C3), also known as type 5 17 β-hydroxysteroid dehydrogenase, is responsible for intratumoral androgen biosynthesis, contributing to the development of castration-resistant prostate cancer (CRPC) and eventual chemotherape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::542f6b08bf08d3952e982df2f5645c06
https://doi.org/10.1158/1535-7163.c.6538467.v1
https://doi.org/10.1158/1535-7163.c.6538467.v1
Autor:
Paul C. Trippier, Trevor M. Penning, Sanjay K. Srivastava, Phumvadee Wangtrakluldee, Tianzhu Zang, Nehal Gupta, Kshitij Verma
Supplementary figure S6: Co-treatments of KV-37 with ENZ do not exert synergistic cytotoxic effects in LNCaP and 22Rv1 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6867cb0a6a514123cea6f3a72d4964f
https://doi.org/10.1158/1535-7163.22506675
https://doi.org/10.1158/1535-7163.22506675
Autor:
Paul C. Trippier, Trevor M. Penning, Sanjay K. Srivastava, Phumvadee Wangtrakluldee, Tianzhu Zang, Nehal Gupta, Kshitij Verma
Supplementary figure S4 & S5: S4: Baccharin does not exert cytotoxicity on prostate cancer cell lines. S5: Percentage cell viability of ENZ at indicated time points across cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35db9202f2b38d1c3f0fec77c739931a
https://doi.org/10.1158/1535-7163.22506681.v1
https://doi.org/10.1158/1535-7163.22506681.v1
Autor:
Trevor M. Penning, Sanjay K. Srivastava, Tianzhu Zang, Paul C. Trippier, Nehal Gupta, Phumvadee Wangtrakluldee, Kshitij Verma
Publikováno v:
Molecular Cancer Therapeutics. 17:1833-1845
Aldo-keto reductase 1C3 (AKR1C3), also known as type 5 17 β-hydroxysteroid dehydrogenase, is responsible for intratumoral androgen biosynthesis, contributing to the development of castration-resistant prostate cancer (CRPC) and eventual chemotherape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d711757ae565e2155eb58e0b23df1a
https://doi.org/10.1158/1535-7163.mct-17-1023
https://doi.org/10.1158/1535-7163.mct-17-1023
Autor:
Meng Huang, Linda C. Hackfeld, Trevor M. Penning, Ian A. Blair, Clementina Mesaros, Richard P. Hodge, Tianzhu Zang
Publikováno v:
Chemical Research in Toxicology. 30:1093-1101
Exposure to petrogenic polycyclic aromatic hydrocarbons (PPAHs) in the food chain is the major human health hazard associated with the Deepwater Horizon oil spill. C4-Phenanthrenes are representative PPAHs present in the crude oil and could contamina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ef3e9eb9dd2298130ae8e93f0c62737
https://doi.org/10.1021/acs.chemrestox.6b00457
https://doi.org/10.1021/acs.chemrestox.6b00457
Autor:
Ian A. Blair, Meng Huang, Qingqing Wang, Daniel Tamae, Tianzhu Zang, Trevor M. Penning, Clementina Mesaros
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 165:342-355
Castration resistant prostate cancer (CRPC), the fatal form of prostate cancer, remains androgen dependent despite castrate levels of circulating testosterone (T) and 5α-dihydrotestosterone (DHT). To investigate mechanisms by which the tumor can syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b86755ff0effdd27740ac5054bdc4fb5
https://doi.org/10.1016/j.jsbmb.2016.08.001
https://doi.org/10.1016/j.jsbmb.2016.08.001
Publikováno v:
Journal of medicinal chemistry. 62(7)
Aldo–keto reductase 1C3 (AKR1C3) catalyzes the synthesis of 9α,11β-prostaglandin (PG) F(2α) and PGF(2α) prostanoids that sustain the growth of myeloid precursors in the bone marrow. The enzyme is overexpressed in acute myeloid leukemia (AML) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2949a47bb55577f5752a7f707db3a60
https://pubmed.ncbi.nlm.nih.gov/30836001
https://pubmed.ncbi.nlm.nih.gov/30836001