Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Tianye Li"'
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-29 (2024)
Abstract The Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)/Cas9 system, a groundbreaking innovation in genetic engineering, has revolutionized our approach to surmounting complex diseases, culminating in CASGEVY™ approved for si
Externí odkaz:
https://doaj.org/article/aafc679c11514c4ba333714e9074b592
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-48 (2024)
Abstract Cytokines are critical in regulating immune responses and cellular behavior, playing dual roles in both normal physiology and the pathology of diseases such as cancer. These molecules, including interleukins, interferons, tumor necrosis fact
Externí odkaz:
https://doaj.org/article/a55d889783594e3f8f5e2cd5852e0f8f
Autor:
Ming Yi, Tianye Li, Mengke Niu, Yuze Wu, Bin Zhao, Zhuoyang Shen, Shengtao Hu, Chaomei Zhang, Xiaojun Zhang, Jing Zhang, Yongxiang Yan, Pengfei Zhou, Qian Chu, Zhijun Dai, Kongming Wu
Publikováno v:
Advanced Science, Vol 11, Iss 43, Pp n/a-n/a (2024)
Abstract In the previous studies, anti‐TGF‐β/PD‐L1 bispecific antibody YM101 is demonstrated, with superior efficacy to anti‐PD‐L1 monotherapy in multiple tumor models. However, YM101 therapy can not achieve complete regression in most tum
Externí odkaz:
https://doaj.org/article/790ba4a189be4c6cb55ed803e64cb386
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract The programmed cell death 1 (PD-1) signaling pathway, a key player in immune checkpoint regulation, has become a focal point in cancer immunotherapy. In the context of cancer, upregulated PD-L1 on tumor cells can result in T cell exhaustion
Externí odkaz:
https://doaj.org/article/c9b496fd3bf840cc94a348cdb1a67900
Publikováno v:
Journal of Materials Research and Technology, Vol 29, Iss , Pp 3566-3574 (2024)
C and Mo in the form of solid solution atom or compound phase is distributed in CoCrFeMnNi high entropy alloy (HEA), which have the effects of solution strengthening or second phase strengthening. CoCrFeMnNi–Mo5C0.5 HEA were prepared by adding C an
Externí odkaz:
https://doaj.org/article/d77e8a6f57e2462a9a6a389fcf47d4f8
Publikováno v:
Biomarker Research, Vol 11, Iss 1, Pp 1-18 (2023)
Abstract Background S100A8 and S100A9 are members of Ca2+-binding EF-hand superfamily, mainly expressed by macrophages and neutrophils. Limited by the poor stability of homodimers, they commonly exist as heterodimers. Beyond acting as antibacterial c
Externí odkaz:
https://doaj.org/article/5f7eb95826cc47ed9db134cb2c9a90be
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundCervical cancer poses a significant global threat to women’s health. However, current therapeutic interventions, such as radiotherapy, chemotherapy, surgical resection, and immune checkpoint inhibitors, face limitations in the advanced st
Externí odkaz:
https://doaj.org/article/50e7020d2c324da39a13b66a8d3305a3
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-55 (2023)
Abstract Immunotherapies have revolutionized the treatment paradigms of various types of cancers. However, most of these immunomodulatory strategies focus on harnessing adaptive immunity, mainly by inhibiting immunosuppressive signaling with immune c
Externí odkaz:
https://doaj.org/article/2511b2e1dbb841e1a6a4f281545a4c1e
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Natural Killer (NK) cells, intrinsic to the innate immune system, are pivotal in combating cancer due to their independent cytotoxic capabilities in antitumor immune response. Unlike predominant treatments that target T cell immunity, the limited suc
Externí odkaz:
https://doaj.org/article/37273c8438f041e1abad84fea04bdf4e
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Ovarian cancer remains a challenging disease with limited treatment options and poor prognosis. The tumor microenvironment (TME) plays a crucial role in tumor growth, progression, and therapy response. One characteristic feature of the TME is the abn
Externí odkaz:
https://doaj.org/article/845f4131552a42f683f743a3470954f1