Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Tianyan Chi"'
Autor:
Wenjing Song, Yang Yao, Heling Zhang, Xin Hao, Liping Zhou, Zhixiao Song, Tiantian Wei, Tianyan Chi, Peng Liu, Xuefei Ji, Libo Zou
Publikováno v:
Molecules, Vol 28, Iss 1, p 390 (2023)
Diabetes mellitus (DM) is a major risk factor for stroke and exacerbates white-matter damage in focal cerebral ischemia. Our previous study showed that the sigma-1 receptor agonist PRE084 ameliorates bilateral common-carotid-artery occlusion-induced
Externí odkaz:
https://doaj.org/article/5e99738512874bba973f19dd4d6a605b
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 121, Iss , Pp 109618- (2020)
Amyloid-β (Aβ) activating the pyroptotic cell pathway has been reported to act as a component in the progression of Alzheimer's disease (AD). As another major pathophysiological protein process in AD, the abnormal hyperphosphorylation of tau protei
Externí odkaz:
https://doaj.org/article/9f0733fbac5d465da4ab4850a4429e27
Autor:
Wenjing Song, Yang Yao, Heling Zhang, Xin Hao, Liping Zhou, Zhixiao Song, Tiantian Wei, Tianyan Chi, Peng Liu, Xuefei Ji, Libo Zou
Publikováno v:
Molecules; Volume 28; Issue 1; Pages: 390
Diabetes mellitus (DM) is a major risk factor for stroke and exacerbates white-matter damage in focal cerebral ischemia. Our previous study showed that the sigma-1 receptor agonist PRE084 ameliorates bilateral common-carotid-artery occlusion-induced
Autor:
Peng Liu, Guoliang Chen, Xuefei Ji, Tianyan Chi, Zheng Zhonghui, Libo Zou, Xuefei Bao, Xiaoli Guo, Xiaojuan Wang, Danyang Liu
Publikováno v:
ACS Chemical Neuroscience. 12:3985-3993
In Alzheimer's disease (AD), damaged Aβ clearance contributes to elevated levels of Aβ that cause a series of cytotoxic cascade reactions. Thus, targeting Aβ clearance has now been considered a valid therapeutic approach for AD. Cellular uptake an
Autor:
Xiaojuan, Wang, Yongqiang, Xue, Yang, Yao, Yang, Li, Xuefei, Ji, Tianyan, Chi, Peng, Liu, Libo, Zou
Publikováno v:
Neurochemistry International. 154:105298
Disrupted mitochondrial fission/fusion balance is consistently involved in neurodegenerative diseases, including Alzheimer's disease. PTEN-induced putative kinase 1 (PINK1), a mitochondrial kinase, has been reported to prevent mitochondrial injury, o
Publikováno v:
The journal of physiological sciences : JPS. 70(1)
Tolfenamic acid, a nonsteroidal anti-inflammatory drug, alleviated learning and memory deficits and decreased the expression of specificity protein 1 (SP1)-mediated cyclin-dependent kinase-5 (CDK5), a major protein kinase that regulates hyperphosphor
Autor:
Shaojie Wang, Ke Ying, Peng Liu, Tianyan Chi, Zhonggui He, Huimin Wang, Libo Zou, Xiaoyu Zhou, Zheng Liu, Xuefei Ji
Publikováno v:
Oxidative Medicine and Cellular Longevity, Vol 2020 (2020)
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity
Diabetic nephropathy (DN) is a chronic diabetic microvascular complication. Hyperactivity of the polyol pathway is involved in the pathogenesis of DN. Aldose reductase (AR), the rate-limiting enzyme of the polyol pathway, is expected to be an effecti
Publikováno v:
Neurochemical Research. 43:1938-1946
Tolfenamic acid (TA), a nonsteroidal anti-inflammatory drug, shows neuroprotective effects and alleviates cognitive deficits in transgenic mouse models of Alzheimer's disease. However, whether TA can prevent the biochemical alterations induced by int
Publikováno v:
European Journal of Pharmacology. 820:18-30
Xanthoceraside, a novel triterpenoid saponin extracted from the husks of Xanthoceras sorbifolia Bunge, has neuroprotective effects in vivo and anti-inflammatory properties in vitro. However, the exact mechanism of xanthoceraside on anti-amyloid beta
Autor:
Lei Yang, Libo Zou, Xiaoli Guo, Peng Liu, Tianyan Chi, Danyang Liu, Lin Zhu, Xuemei Zhao, Xuefei Ji
Publikováno v:
Psychopharmacology. 235:337-349
Alzheimer’s disease (AD) is characterized by memory loss and synaptic damage. Previous studies suggested that xanthoceraside decreases glutamate-induced PC12 cell death, ameliorates memory deficits, and increases the number of dendritic spines in A