Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Tianxiao Wu"'
Autor:
Qiaohua Qin, Ruifeng Wang, Qinglin Fu, Guoqi Zhang, Tianxiao Wu, Nian Liu, Ruicheng Lv, Wenbo Yin, Yin Sun, Yixiang Sun, Dongmei Zhao, Maosheng Cheng
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2241-2255 (2022)
FAK mediated tumour cell migration, invasion, survival, proliferation and regulation of tumour stem cells through its kinase-dependent enzymatic functions and kinase-independent scaffolding functions. At present, the development of FAK PROTACs has be
Externí odkaz:
https://doaj.org/article/fa10857483d44d72aa9375517b729cd6
Autor:
Xiaolin Zhang, Yi Cai, Xu Su, Quanmin Jing, Haiwei Liu, Kun Na, Miaohan Qiu, Xiaoxiang Tian, Dan Liu, Tianxiao Wu, Chenghui Yan, Yaling Han
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/2b7e45a115c248618ea8d8a857899fd4
Autor:
Xiaolin Zhang, Yi Cai, Xu Su, Quanmin Jing, Haiwei Liu, Kun Na, Miaohan Qiu, Xiaoxiang Tian, Dan Liu, Tianxiao Wu, Chenghui Yan, Yaling Han
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
ObjectiveThe occurrence of cardiovascular adverse events in the first year after ST-acute myocardial infarction (STEMI) remains high; therefore, identification of patients with poor prognosis is essential for early intervention. This study aimed to e
Externí odkaz:
https://doaj.org/article/79efccb076de4264a6c440e0816b4db6
Publikováno v:
Remote Sensing, Vol 14, Iss 18, p 4588 (2022)
Drought-induced risk has attracted the attention of many scholars, but the risk of combined events caused by drought and high-temperature heat waves still needs further study. Based on MODIS products and meteorological data, the spatiotemporal variat
Externí odkaz:
https://doaj.org/article/63ac308d49a347579aae8666da2b3ff5
Publikováno v:
Remote Sensing, Vol 14, Iss 16, p 3895 (2022)
Much attention has recently been devoted to the qualitative relationship between climate factors and drought; however, the influences of climate variability, land-use/cover changes (LUCC), and other human activities on drought have rarely been quanti
Externí odkaz:
https://doaj.org/article/375e1b2518f04da2a3d6e92649602a29
Autor:
Tianru Xue, Yueming Wang, Yuwei Chen, Jianxin Jia, Maoxing Wen, Ran Guo, Tianxiao Wu, Xuan Deng
Publikováno v:
Remote Sensing, Vol 13, Iss 13, p 2607 (2021)
Dimensionality reduction (DR) is of great significance for simplifying and optimizing hyperspectral image (HSI) features. As a widely used DR method, kernel minimum noise fraction (KMNF) transformation preserves the high-order structures of the origi
Externí odkaz:
https://doaj.org/article/3d478aeb9bd4462abf4fddf66c5f44fe
Autor:
Tianxiao Wu, Yu Pang, Jing Guo, Wenbo Yin, Mingyue Zhu, Chenzhou Hao, Kai Wang, Jian Wang, Dongmei Zhao, Maosheng Cheng
Publikováno v:
Molecules, Vol 23, Iss 2, p 417 (2018)
A series of novel 2,4-diaminoquinazoline derivatives were designed, synthesized, and evaluated as p21-activated kinase 4 (PAK4) inhibitors. All compounds showed significant inhibitory activity against PAK4 (half-maximal inhibitory concentration IC50
Externí odkaz:
https://doaj.org/article/3d0076aed0404249919b4424bc10dd13
Autor:
Yin Sun, Yanli Xue, Hongbing Liu, Shuyi Mu, Pengkun Sun, Yu Sun, Lin Wang, Hanxun Wang, Jingkai Wang, Tianxiao Wu, Wenbo Yin, Qiaohua Qin, Yixiang Sun, Huali Yang, Dongmei Zhao, Maosheng Cheng
Publikováno v:
Journal of Medicinal Chemistry. 66:2396-2421
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3aedbfb08586ec2357e470ff27b85542
https://doi.org/10.1021/acs.jmedchem.2c02124
https://doi.org/10.1021/acs.jmedchem.2c02124
Design, synthesis and biological evaluation of pyrazolo[3,4-b]pyridine derivatives as TRK inhibitors
Autor:
Nian Liu, Xin Wang, Qinglin Fu, Qiaohua Qin, Tianxiao Wu, Ruicheng Lv, Dongmei Zhao, Maosheng Cheng
Publikováno v:
RSC Medicinal Chemistry. 14:85-102
Based on scaffold hopping and computer-aid drug design, 38 pyrazolo[3,4-b]pyridine derivatives were synthesised. Among them, compound C03 showed acceptable activity with an IC50 value of 56 nM to TRKA kinase.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbd4267702ec096c430958e58edde539
https://doi.org/10.1039/d2md00334a
https://doi.org/10.1039/d2md00334a
Publikováno v:
Optical Engineering. 61
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91a4b594e593eb5af903acf9aefd521f
https://doi.org/10.1117/1.oe.61.9.093103
https://doi.org/10.1117/1.oe.61.9.093103