TCR and Inflammatory Signals Tune Human MAIT Cells to Exert Specific Tissue Repair and Effector Functions

Autor: Tianqi Leng, Hossain Delowar Akther, Carl-Philipp Hackstein, Kate Powell, Thomas King, Matthias Friedrich, Zoe Christoforidou, Sarah McCuaig, Mastura Neyazi, Carolina V. Arancibia-Cárcamo, Joachim Hagel, Fiona Powrie, Raphael Sanches Peres, Val Millar, Daniel Ebner, Rajesh Lamichhane, James Ussher, Timothy S.C. Hinks, Emanuele Marchi, Chris Willberg, Paul Klenerman

Publikováno v: Cell Reports, Vol 28, Iss 12, Pp 3077-3091.e5 (2019)

Summary: MAIT cells are an unconventional T cell population that can be activated through both TCR-dependent and TCR-independent mechanisms. Here, we examined the impact of combinations of TCR-dependent and TCR-independent signals in human CD8+ MAIT

Externí odkaz: https://doaj.org/article/f78e3319ea4b4781a9075ab9de1e2008

Antibody opsonization enhances MAIT cell responsiveness to bacteria via a TNF-dependent mechanism

Autor: Zoltán, Bánki, Lisette, Krabbendam, Dominik, Klaver, Tianqi, Leng, Simon, Kruis, Hema, Mehta, Brigitte, Müllauer, Dorothea, Orth-Höller, Heribert, Stoiber, Christian B, Willberg, Paul, Klenerman

Publikováno v: Immunology and Cell Biology

Mucosal‐associated invariant T (MAIT) cells are an abundant human T‐cell subset with antimicrobial properties. They can respond to bacteria presented via antigen‐presenting cells (APCs) such as macrophages, which present bacterially derived lig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::12e928a840da328c15912d8c71eef5ad
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85061965739&origin=inward

Human MAIT Cell Activation In Vitro

Autor: Nicholas M. Provine, Joachim Hagel, Christian B. Willberg, Carl-Philipp Hackstein, Lucy C. Garner, Paul Klenerman, Matthew Bilton, Ali Amini, Tianqi Leng, Prabhjeet Phalora, Matthew Edmans, Hema Mehta, Hossain Delowar Akther

Publikováno v: Methods in Molecular Biology ISBN: 9781071602065

Item description: Chapter 7 in book 'MAIT Cells' (2020), ed H Kaipe and I Magalhaes. Methods in Molecular Biology, volume 2098. Mucosal-associated invariant T (MAIT) cells are an abundant innate-like T cell subset in humans, enriched in mucosal tissu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bac90e68144b0c11388d7b3a9e301a50
https://pubmed.ncbi.nlm.nih.gov/31792818

Synergistic activation of pro-inflammatory type-2 CD8

Autor: Jian Luo, Emanuele Marchi, Clare Connolly, Ian D. Pavord, Tianqi Leng, Paul Klenerman, Jennifer L Cane, Rahul Shrimanker, Christian B. Willberg, Graham S. Ogg, Mona Bafadhel, Jamie Matthews, Luzheng Xue, Catherine Borg, Wentao Chen, W Liu, Simei Go, Samantha Thulborn, Hinks Tsc., Linda Stöger, Ayako Kurioka, Adaikalavan Ramasamy, Timothy J. Powell, Bart Hilvering, Maryam Salimi, Ratko Djukanovic

Publikováno v: Mucosal Immunology
Hilvering, B, Hinks, T S C, Stöger, L, Marchi, E, Salimi, M, Shrimanker, R, Liu, W, Chen, W, Luo, J, Go, S, Powell, T, Cane, J, Thulborn, S, Kurioka, A, Leng, T, Matthews, J, Connolly, C, Borg, C, Bafadhel, M, Willberg, C B, Ramasamy, A, Djukanović, R, Ogg, G, Pavord, I D, Klenerman, P & Xue, L 2018, ' Synergistic activation of pro-inflammatory type-2 CD8 + T lymphocytes by lipid mediators in severe eosinophilic asthma ', Mucosal Immunology, vol. 11, no. 5, pp. 1408-1419 . https://doi.org/10.1038/s41385-018-0049-9
Mucosal Immunology, 11(5), 1408-1419. Nature Publishing Group

Human type-2 CD8+ T cells are a cell population with potentially important roles in allergic disease. We investigated this in the context of severe asthma with persistent airway eosinophilia—a phenotype associated with high exacerbation risk and re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53012d6409c0b91c7906302381751c3d
https://pubmed.ncbi.nlm.nih.gov/30518781

Diverse Streptococcus pneumoniae Strains Drive a Mucosal-Associated Invariant T-Cell Response Through Major Histocompatibility Complex class I-Related Molecule-Dependent and Cytokine-Driven Pathways

Autor: Ayako, Kurioka, Bonnie, van Wilgenburg, Reza Rezaei, Javan, Ryan, Hoyle, Andries J, van Tonder, Caroline L, Harrold, Tianqi, Leng, Lauren J, Howson, Dawn, Shepherd, Vincenzo, Cerundolo, Angela B, Brueggemann, Paul, Klenerman

Publikováno v: The Journal of Infectious Diseases

Human MAIT cells respond to diverse pneumococcal strains. These share a conserved riboflavin operon providing the MAIT-cell ligand, although MAIT cell triggering in vitro depends on the metabolic state of the bacteria and the nature of the antigen pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e7dd37c2b6b46b34d9499bff76931abb
https://pubmed.ncbi.nlm.nih.gov/29267892