Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Tianmu Wen"'
Publikováno v:
Biomolecules, Vol 13, Iss 10, p 1430 (2023)
The capacity for cancer cells to metastasize to distant organs depends on their ability to execute the carefully choreographed processes of cell adhesion and migration. As most human cancers are of epithelial origin (carcinoma), the transcriptional d
Externí odkaz:
https://doaj.org/article/d81d4d63c839450889705b76efbada8d
Publikováno v:
Biomolecules, Vol 13, Iss 9, p 1297 (2023)
Cytoplasmic phosphoinositides (PI) are critical regulators of the membrane–cytosol interface that control a myriad of cellular functions despite their low abundance among phospholipids. The metabolic cycle that generates different PI species is cru
Externí odkaz:
https://doaj.org/article/d7c03967a5dc46f58ebecafc5374fb22
Autor:
Mo Chen, Suyong Choi, Tianmu Wen, Changliang Chen, Narendra Thapa, Jeong Hyo Lee, Vincent L. Cryns, Richard A. Anderson
Publikováno v:
Nat Cell Biol
The tumor suppressor p53 and phosphoinositide 3-kinase (PI3K)-Akt pathway have fundamental roles in regulating cell growth and apoptosis, and they are frequently mutated in cancer. Here, we show that genotoxic stress induces nuclear Akt activation by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c191b42cfd067517574a94085d35bf1f
https://doi.org/10.1038/s41556-022-00949-1
https://doi.org/10.1038/s41556-022-00949-1
Publikováno v:
Nat Cell Biol
The canonical model of agonist-stimulated phosphatidylinositol-3-OH kinase (PI3K)-Akt signalling proposes that PI3K is activated at the plasma membrane, where receptors are activated and phosphatidylinositol-4,5-bisphosphate is concentrated. Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00f1a589f4a2ff9c321191feb389fe2f
https://doi.org/10.1038/s41556-020-00596-4
https://doi.org/10.1038/s41556-020-00596-4
Autor:
Tianmu Wen, Mo Chen, Vincent L. Cryns, Narendra Thapa, Vishwanatha K. Chandrahas, Suyong Choi, Richard A. Anderson, Hudson T Horn
Publikováno v:
Cell Cycle
Accumulating evidence reveals that nuclear phosphoinositides (PIs) serve as central signaling hubs that control a multitude of nuclear processes by regulating the activity of nuclear proteins. In response to cellular stressors, PIs accumulate in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec1a78345680041fafa7c1260e2fab02
https://doi.org/10.1080/15384101.2019.1711316
https://doi.org/10.1080/15384101.2019.1711316
Autor:
Vincent L. Cryns, Changliang Chen, Mo Chen, Suyong Choi, Narendra Thapa, Richard A. Anderson, Tianmu Wen
The tumor suppressor p53 and the phosphoinositide 3-kinase (PI3K)-Akt pathway have fundamental roles in regulating cell growth, apoptosis and are frequently mutated in cancer. Here, we show that genotoxic stress induces nuclear Akt activation by a p5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bad9cfe8622c6e615d4c85e9e591f5f3
https://doi.org/10.1101/2021.09.17.460854
https://doi.org/10.1101/2021.09.17.460854
Publikováno v:
Methods in Molecular Biology ISBN: 9781071611418
Methods Mol Biol
Methods Mol Biol
Proximity ligation assay (PLA) is a well-established method for detecting in situ interactions between two epitopes with high resolution and specificity. Notably, PLA is not only a robust method for studying protein-protein interaction, but also an e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d18ad9a1135981759ed772be7bab429
https://doi.org/10.1007/978-1-0716-1142-5_9
https://doi.org/10.1007/978-1-0716-1142-5_9
Autor:
Suyong Choi, Oisun Jung, Christina Baum, Mo Chen, Tianmu Wen, Richard A. Anderson, Paul F. Lambert, Narendra Thapa, Alan C. Rapraeger
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Epidermal growth factor receptor (EGFR) and its downstream phosphoinositide 3-kinase (PI3K) pathway are commonly deregulated in cancer. Recently, we have shown that the IQ motif-containing GTPase-activating protein 1 (IQGAP1) provides a molecular pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbcf9c173a20ae392a9e49b8b5f1c146
http://europepmc.org/articles/PMC6591252
http://europepmc.org/articles/PMC6591252
Autor:
Tianmu Wen, Narendra Thapa, Richard A. Anderson, Alan C. Rapraeger, Oisun Jung, Suyong Choi, Mo Chen, Paul F. Lambert
Epidermal growth factor receptor (EGFR) and its downstream phosphatidylinositol 3-kinase (PI3K) pathway are commonly deregulated in many cancers including head and neck cancer (HNC). Recently, we have shown that the IQ motif-containing GTPase-activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1227ad18dc229806cebf06f1157a73ec
https://doi.org/10.1101/250936
https://doi.org/10.1101/250936
Autor:
Christian V. Baglini, Fuyuhiko Tamanoi, John M. Asara, Jeffrey J. Heard, Alexander J. Valvezan, Menghang Xia, Brendan D. Manning, Srilatha Sakamuru, Hilaire C. Lam, Elizabeth P. Henske, Harilaos Filippakis, Ruili Huang, Christopher M. Austin, Tianmu Wen, Amine Belaid, Nguyen Truong Sinh
Publikováno v:
Clinical Cancer Research. 23:A09-A09
Tuberous sclerosis complex (TSC) is a multisystem disorder that affects multiple organ systems, including tumors of the brain, heart, kidney, skin and lung. TSC is caused by germline loss-of-function gene mutations in TSC1 or TSC2, which inhibit the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::655b449bffccc1599292f4f326caf80e
https://doi.org/10.1158/1557-3265.pmccavuln16-a09
https://doi.org/10.1158/1557-3265.pmccavuln16-a09