Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Tianling Ou"'
Autor:
Mai H. Tran, Hajeung Park, Christopher L. Nobles, Pabalu Karunadharma, Li Pan, Guocai Zhong, Haimin Wang, Wenhui He, Tianling Ou, Gogce Crynen, Kelly Sheptack, Ian Stiskin, Huihui Mou, Michael Farzan
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 24, Iss , Pp 40-53 (2021)
CRISPR effector proteins introduce double-stranded breaks into the mammalian genome, facilitating gene editing by non-homologous end-joining or homology-directed repair. Unlike the more commonly studied Cas9, the CRISPR effector protein Cas12a/Cpf1 r
Externí odkaz:
https://doaj.org/article/528d54708b9d465fa463c4fbb4f6a469
Publikováno v:
PLoS Pathogens, Vol 17, Iss 1, p e1009212 (2021)
Hydroxychloroquine, used to treat malaria and some autoimmune disorders, potently inhibits viral infection of SARS coronavirus (SARS-CoV-1) and SARS-CoV-2 in cell-culture studies. However, human clinical trials of hydroxychloroquine failed to establi
Externí odkaz:
https://doaj.org/article/c0eaebee92c84c4aa32b8319b2969a3a
Autor:
Wenhui He, Tianling Ou, Nickolas Skamangas, Charles C. Bailey, Naomi Bronkema, Yan Guo, Yiming Yin, Valerie Kobzarenko, Xia Zhang, Andi Pan, Xin Liu, Ava E. Allwardt, Debasis Mitra, Brian Quinlan, Rogier W. Sanders, Hyeryun Choe, Michael Farzan
SUMMARYV2-glycan/apex broadly neutralizing antibodies (bnAbs) recognize a closed quaternary epitope of the HIV-1 envelope glycoprotein (Env). This closed structure is necessary to elicit apex antibodies and useful to guide maturation of other bnAb cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9973b1c5802667f29c7af056373e7463
https://doi.org/10.1101/2022.11.07.515497
https://doi.org/10.1101/2022.11.07.515497
Autor:
Wenhui He, Guocai Zhong, Mai H. Tran, Li Pan, Huihui Mou, Michael Farzan, Ian Stiskin, Kelly R Sheptack, HaJeung Park, Gogce Crynen, Pabalu Karunadharma, Christopher L. Nobles, Tianling Ou, Haimin Wang
Publikováno v:
Molecular Therapy. Nucleic Acids
Molecular Therapy: Nucleic Acids, Vol 24, Iss, Pp 40-53 (2021)
Molecular Therapy: Nucleic Acids, Vol 24, Iss, Pp 40-53 (2021)
CRISPR effector proteins introduce double-stranded breaks into the mammalian genome, facilitating gene editing by non-homologous end-joining or homology-directed repair. Unlike the more commonly studied Cas9, the CRISPR effector protein Cas12a/Cpf1 r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec4b3fcee001979654a4dfe9cab0b422
http://europepmc.org/articles/PMC7940699
http://europepmc.org/articles/PMC7940699
Autor:
Michael Farzan, Zachary J Tickner, Yujun Li, Guocai Zhong, Mai H. Tran, Haimin Wang, Huihui Mou, Tianling Ou, Yiming Yin, Wenhui He, Huitian Diao
Publikováno v:
Nature biotechnology
Widespread use of gene therapy technologies is limited in part by the lack of small genetic switches with wide dynamic ranges that control transgene expression without the requirement of additional protein components1-5. In this study, we engineered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4475f7db0a01909ea2046f9e9c899306
http://europepmc.org/articles/PMC7008088
http://europepmc.org/articles/PMC7008088
Autor:
Pabalu Karunadharma, Brian D. Quinlan, Yan Guo, Mai H. Tran, Yiming Yin, Meredith E. Davis-Gardner, Tianling Ou, Haimin Wang, Xia Zhang, Michael Farzan, Guocai Zhong, HaJeung Park, Wenhui He
Publikováno v:
Mol Ther
B cells have been engineered ex vivo to express an HIV-1 broadly neutralizing antibody (bNAb). B-cell reprograming may be scientifically and therapeutically useful, but current approaches limit B-cell repertoire diversity and disrupt the organization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::461e82cbaba74179dcba6f75a50cf71c
https://europepmc.org/articles/PMC8753427/
https://europepmc.org/articles/PMC8753427/
Publikováno v:
Proc Natl Acad Sci U S A
Three variable 2 (V2) loops of HIV-1 envelope glycoprotein (Env) trimer converge at the Env apex to form the epitope of an important classes of HIV-1 broadly neutralizing antibodies (bNAbs). These V2-glycan/apex antibodies are exceptionally potent bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ad575017fb4e439e3fa40710bfbc097
https://pubmed.ncbi.nlm.nih.gov/34261793
https://pubmed.ncbi.nlm.nih.gov/34261793
Publikováno v:
PLoS Pathogens, Vol 17, Iss 1, p e1009212 (2021)
PLoS Pathogens
PLoS Pathogens
Hydroxychloroquine, used to treat malaria and some autoimmune disorders, potently inhibits viral infection of SARS coronavirus (SARS-CoV-1) and SARS-CoV-2 in cell-culture studies. However, human clinical trials of hydroxychloroquine failed to establi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77f6a57ed6399ef98d69058166c3d05a
https://doi.org/10.1101/2020.07.22.216150
https://doi.org/10.1101/2020.07.22.216150