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pro vyhledávání: '"Tianhai Yuan"'
Autor:
Jing Wang, Zhulin Zhang, Tadimeti S. Rao, Jun Yu, Xiong Li, Tianhai Yuan, Wei-Guo Su, Qing Wang, Zheng Zhang, Yu Cai, Hong Jia, Scott D. Bembenek, Jennifer Venable, James P. Edwards, Yang Sai, Fuying Shi, Jianyang Weng, Wei Chen, Ping Ren, Guangxiu Dai, Kun Xiao
Publikováno v:
Journal of medicinal chemistry. 62(10)
An electronic density model was developed and used to identify a novel pyrrolotriazinone replacement for a quinazolinone, a commonly used moiety to impart selectivity in inhibitors for PI3Kγ and PI3Kδ. Guided by molecular docking, this new specific