Molecular Profiling of DNA Methylation and Alternative Splicing of Genes in Skeletal Muscle of Obese Rabbits

Autor: Yanhong Li, Jie Wang, Mauricio A. Elzo, Huimei Fan, Kun Du, Siqi Xia, Jiahao Shao, Tianfu Lai, Shenqiang Hu, Xianbo Jia, Songjia Lai

Publikováno v: Current Issues in Molecular Biology, Vol 43, Iss 3, Pp 1558-1575 (2021)

DNA methylation and the alternative splicing of precursor messenger RNAs (pre-mRNAs) are two important genetic modification mechanisms. However, both are currently uncharacterized in the muscle metabolism of rabbits. Thus, we constructed the Tianfu b

Externí odkaz: https://doaj.org/article/4f63b9a3891b4553b4da2cc8932a78e8

MiR-9-5p promotes rabbit preadipocyte differentiation by suppressing leptin gene expression

Autor: Gang Luo, Shenqiang Hu, Tianfu Lai, Jie Wang, Li Wang, Songjia Lai

Publikováno v: Lipids in Health and Disease, Vol 19, Iss 1, Pp 1-11 (2020)

Abstract Background MicroRNAs (miRNAs) are a class of small non-coding RNAs, which participate in the regulation of cell differentiation. Previous studies have demonstrated that miR-9-5p plays a key role in cancer cell development, but the mechanisms

Externí odkaz: https://doaj.org/article/f1f9401dcc064c31b187650cbfa083c8

Untargeted Metabolomic Characteristics of Skeletal Muscle Dysfunction in Rabbits Induced by a High Fat Diet

Autor: Huimei Fan, Yanhong Li, Jie Wang, Jiahao Shao, Tao Tang, Mauricio A. Elzo, Li Wang, Tianfu Lai, Yuan Ma, Mingchuan Gan, Xianbo Jia, Songjia Lai

Publikováno v: Animals, Vol 11, Iss 6, p 1722 (2021)

Type 2 diabetes and metabolic syndrome caused by a high fat diet (HFD) have become public health problems worldwide. These diseases are characterized by the oxidation of skeletal muscle mitochondria and disruption of insulin resistance, but the mecha

Externí odkaz: https://doaj.org/article/4858f636c7b8449db3b9248bc2595fe3

Intramuscular adipocyte and fatty acid differences between high‐fat and control rabbit groups subject to a restricted diet

Autor: Li Yanhong, Xianbo Jia, Jiahao Shao, Jie Wang, Tianfu Lai, Mingchuan Gan, Mauricio A. Elzo, Tao Tang, Shenqiang Hu, Yuan Ma, Songjia Lai

Publikováno v: Veterinary Medicine and Science
Veterinary Medicine and Science, Vol 7, Iss 5, Pp 2051-2060 (2021)

Fatty acids of intramuscular fat (IMF) in rabbits can influence meat quality, but it is unclear which fatty acids benefit to human health. A rabbit model of weight gain and weight loss was constructed using two rabbit groups and two growth stages. St

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28f6cc9addad733437754f8e455320d8
https://doi.org/10.1002/vms3.576

Molecular Profiling of DNA Methylation and Alternative Splicing of Genes in Skeletal Muscle of Obese Rabbits

Autor: Tianfu Lai, Kun Du, Xianbo Jia, Jiahao Shao, Li Yanhong, Jie Wang, Mauricio A. Elzo, Siqi Xia, Huimei Fan, Hu Shenqiang, Songjia Lai

Publikováno v: Current Issues in Molecular Biology
Volume 43
Issue 3
Pages 110-1575
Current Issues in Molecular Biology, Vol 43, Iss 110, Pp 1558-1575 (2021)

DNA methylation and the alternative splicing of precursor messenger RNAs (pre-mRNAs) are two important genetic modification mechanisms. However, both are currently uncharacterized in the muscle metabolism of rabbits. Thus, we constructed the Tianfu b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0189db4a16a1f2ee582acaa3e5e37c9a
https://pubmed.ncbi.nlm.nih.gov/34698087