Targeting phosphodiesterase 4 as a therapeutic strategy for cognitive improvement

Autor: Xuemei Wei, Guoqi Yu, Hualiang Shen, Yanjuan Luo, Tianbo Shang, Runpu Shen, Meiyang Xi, Haopeng Sun

Publikováno v: Bioorganic chemistry. 130

Phosphodiesterase 4 (PDE4), the largest member of PDE family, is highly expressed in mammalian brain. It selectively hydrolyzes the second messenger cyclic adenosine monophosphate (cAMP), a correlate of brain functions including learning, memory and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cbcc91d344788f5377ad4bafe9fd693
https://pubmed.ncbi.nlm.nih.gov/36413930

Synthesis of polysubstituted azetidines via cascade trifluoromethylation/cyclization of N-allyl ynamides

Autor: Genlai Zhou, Xiaojuan Wang, Jingwen Su, Zheliang Yuan, Yihui Bai, Gangguo Zhu, Tianbo Shang

Publikováno v: Organic Chemistry Frontiers. 8:4473-4478

Traditional methods for the transformation of N-allyl ynamides rely on the formation of a ketenimine intermediate or its equivalent, while novel reaction modes remain to be developed. Herein, a cascade trifluoromethylation/cyclization of N-allyl sulf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8175caf0bcfa40ae876a734302155817
https://doi.org/10.1039/d1qo00559f

Oxone®-mediated halocyclization/demethylation of 2-alkynylthioanisoles with sodium halides towards 3-halobenzo[b]thiophenes

Autor: Xinyu Chen, Zhebing Zhang, Tao Sun, Haokun Cai, Yuzhen Gao, Tao Cai, Tianbo Shang, Yanjuan Luo, Guoqi Yu, Hualiang Shen, Guofeng Wu, Yanlin Hei, Enmin Li, Gang Fan

Publikováno v: Tetrahedron Letters. 90:153614

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::adc4ba6e4e626d52f35ff2a283aebe31
https://doi.org/10.1016/j.tetlet.2021.153614

Photocatalytic 1,1-Hydrofluoroalkylation of Alkynes with a Concurrent Vicinal Acylation: An Access to Fluoroalkylated Cyclic Ketones

Autor: Yimei Wan, Zenghui Lu, Gangguo Zhu, Tianbo Shang

Publikováno v: Organic letters. 21(11)

A visible-light-induced 1,1-hydrofluoroalkylation of alkynes with a concomitant vicinal acylation is developed using tetrahydrofuran (THF) as the hydrogen atom source. Various fluoroalkylated cyclic ketones, such as indanones, chroman-4-ones, 2,3-dih

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::241643d41967ca7d2600806ced6212b8
https://pubmed.ncbi.nlm.nih.gov/31185535

Crucial size effect on dicarbonylation of acetylene over Pd/CsHPMo heterogeneous catalysts.

Autor: Xuemei W; College of Chemistry and Chemical Engineering, Shaoxing University, Shaoxing, 312000, China. srunpu@usx.edu.cn.; Zhejiang Engineering Research Center of Fat-soluble Vitamin, Shaoxing University, Shaoxing, 312000, China.; College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027, China. xzchen@zju.edu.cn., Kai W; College of Chemistry and Chemical Engineering, Shaoxing University, Shaoxing, 312000, China. srunpu@usx.edu.cn.; Zhejiang Engineering Research Center of Fat-soluble Vitamin, Shaoxing University, Shaoxing, 312000, China., Guofeng W; Zhejiang Medicine Co Ltd, Shaoxing 312000, PR China., Guoqi Y; College of Chemistry and Chemical Engineering, Shaoxing University, Shaoxing, 312000, China. srunpu@usx.edu.cn.; Zhejiang Engineering Research Center of Fat-soluble Vitamin, Shaoxing University, Shaoxing, 312000, China., Hualiang S; College of Chemistry and Chemical Engineering, Shaoxing University, Shaoxing, 312000, China. srunpu@usx.edu.cn.; Zhejiang Engineering Research Center of Fat-soluble Vitamin, Shaoxing University, Shaoxing, 312000, China., Tao C; College of Chemistry and Chemical Engineering, Shaoxing University, Shaoxing, 312000, China. srunpu@usx.edu.cn.; Zhejiang Engineering Research Center of Fat-soluble Vitamin, Shaoxing University, Shaoxing, 312000, China., Yanjuan L; College of Chemistry and Chemical Engineering, Shaoxing University, Shaoxing, 312000, China. srunpu@usx.edu.cn.; Zhejiang Engineering Research Center of Fat-soluble Vitamin, Shaoxing University, Shaoxing, 312000, China., Tianbo S; College of Chemistry and Chemical Engineering, Shaoxing University, Shaoxing, 312000, China. srunpu@usx.edu.cn.; Zhejiang Engineering Research Center of Fat-soluble Vitamin, Shaoxing University, Shaoxing, 312000, China., Xinzhi C; College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027, China. xzchen@zju.edu.cn., Runpu S; College of Chemistry and Chemical Engineering, Shaoxing University, Shaoxing, 312000, China. srunpu@usx.edu.cn.; Zhejiang Engineering Research Center of Fat-soluble Vitamin, Shaoxing University, Shaoxing, 312000, China., Bin H; State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China. hcom@licp.cas.cn.

Publikováno v: Dalton transactions (Cambridge, England : 2003) [Dalton Trans] 2024 Nov 19; Vol. 53 (45), pp. 18217-18225. Date of Electronic Publication: 2024 Nov 19.