Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Tian-qi Niu"'
Publikováno v:
Chemico-Biological Interactions. 100:77-84
Since the toxicities of sulfur mustard are attributed to DNA alkylation, levels of DNA modification in exposed cells should correlate with the intensity of exposure. We have found that 32 P-postlabeling can be used successfully to detect the major ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7f96867c0a39da7575f669f597e0393
https://doi.org/10.1016/s0009-2797(96)03690-3
https://doi.org/10.1016/s0009-2797(96)03690-3
Publikováno v:
Carcinogenesis. 17:2249-2252
The toxic effects of sulfur mustard have been attributed to DNA modification with the formation of 7-hydroxyethylthioethyl guanine, 3-hydroxyethylthioethyl adenine and the cross-link, di-(2-guanin-7-yl-ethyl)sulfide. To investigate the action of bact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a4a24423a0edf79fd60c51a14bb41e9
https://doi.org/10.1093/carcin/17.10.2249
https://doi.org/10.1093/carcin/17.10.2249
Publikováno v:
Proceedings of the National Academy of Sciences. 91:7232-7236
Many antitumor agents, including the mustards, form N-7 deoxyguanosine adducts in DNA that are difficult to quantitate by the 32P-postlabeling procedure because of their instability. We have developed a method that is successful for the analysis of s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c848ead84bb58fb91a78a8385bf65325
https://doi.org/10.1073/pnas.91.15.7232
https://doi.org/10.1073/pnas.91.15.7232
Publikováno v:
Chemico-Biological Interactions. 91:39-49
Sulfur mustard is acutely toxic to the skin, eyes, and respiratory tract, and is considered carcinogenic to humans by the IARC. Since all of these toxicities are thought to be initiated by DNA alkylation, the level of DNA damage should serve as a bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d5922f92d5c7ce5967861b32095e7e1
https://doi.org/10.1016/0009-2797(94)90005-1
https://doi.org/10.1016/0009-2797(94)90005-1
Publikováno v:
Carcinogenesis. 14(2)
The haloethylnitrosoureas form a cytotoxic DNA cross-link in a series of reactions which involves initial alkylation of the O6 position of guanine and rearrangement to the intermediate, 1,O6-ethanoguanine; 1,O6-ethanoguanine then reacts with a neighb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89f1aa8dc4991c2f76cf383776808cd4
https://pubmed.ncbi.nlm.nih.gov/8435860
https://pubmed.ncbi.nlm.nih.gov/8435860
Publikováno v:
Journal of the American Chemical Society. 111:1429-1436
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c29faa3f884cb630dbaa7e1c746169c
https://doi.org/10.1021/ja00186a043
https://doi.org/10.1021/ja00186a043