Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Tian-Qiang Sun"'
Autor:
Yonchu Jenkins, Tian-Qiang Sun, Vadim Markovtsov, Marc Foretz, Wei Li, Henry Nguyen, Yingwu Li, Alison Pan, Gerald Uy, Lisa Gross, Kristen Baltgalvis, Stephanie L Yung, Tarikere Gururaja, Taisei Kinoshita, Alexander Owyang, Ira J Smith, Kelly McCaughey, Kathy White, Guillermo Godinez, Raniel Alcantara, Carmen Choy, Hong Ren, Rachel Basile, David J Sweeny, Xiang Xu, Sarkiz D Issakani, David C Carroll, Dane A Goff, Simon J Shaw, Rajinder Singh, Laszlo G Boros, Marc-André Laplante, Bruno Marcotte, Rita Kohen, Benoit Viollet, André Marette, Donald G Payan, Todd M Kinsella, Yasumichi Hitoshi
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e81870 (2013)
Modulation of mitochondrial function through inhibiting respiratory complex I activates a key sensor of cellular energy status, the 5'-AMP-activated protein kinase (AMPK). Activation of AMPK results in the mobilization of nutrient uptake and cataboli
Externí odkaz:
https://doaj.org/article/9f3bbe0f39b0498d932c53dbf27c0985
Autor:
Simon J. Shaw, Dane A. Goff, David C. Carroll, Rajinder Singh, David J. Sweeny, Gary Park, Yonchu Jenkins, Vadim Markovtsov, Tian-Qiang Sun, Sarkiz D. Issakani, Yasumichi Hitoshi, Donald G. Payan
Publikováno v:
Bioorganicmedicinal chemistry. 71
Using an in-cell AMPK activation assay, we have developed structure-activity relationships around a hit pyridine dicarboxamide 5 that resulted in 40 (R419). A particular focus was to retain the on-target potency while also improving microsomal stabil
Autor:
Adrian Vallejo, Pawel K. Mazur, Kaja Kostyrko, Fernando Lecanda, Anuradha Tathireddy, O. Erice, Rita Fragoso, Jun Lu, E. Alejandro Sweet-Cordero, Karmele Valencia, Nerea Razquin, Chang-Zheng Chen, Mariano Ponz-Sarvise, Puri Fortes, Natasha M. Flores, Alex G. Lee, Silvestre Vicent, Tian Qiang Sun, Marta Roman, Simone Hausmann, Elizabeth Guruceaga, Itziar Migueliz, Rodrigo Entrialgo-Cadierno, Leanne C. Sayles
Publikováno v:
The Journal of Clinical Investigation
Few therapies are currently available for patients with KRAS-driven cancers, highlighting the need to identify new molecular targets that modulate central downstream effector pathways. Here we found that the microRNA (miRNA) cluster including miR181a
Autor:
Yonchu Jenkins1 (AUTHOR) yjenkins@rigel.com, Tian-Qiang Sun1 (AUTHOR), Yingwu Li1 (AUTHOR), Markovtsov, Vadim1 (AUTHOR), Uy, Gerald1 (AUTHOR), Gross, Lisa1 (AUTHOR), Goff, Dane A.1 (AUTHOR), Shaw, Simon J.1 (AUTHOR), Boralsky, Luke1 (AUTHOR), Singh, Rajinder1 (AUTHOR), Payan, Donald G.1 (AUTHOR), Yasumichi Hitoshi1 (AUTHOR)
Publikováno v:
BMC Research Notes. 9/25/2014, Vol. 7, p1-10. 10p. 4 Diagrams, 2 Graphs.
Autor:
Rajinder Singh, Yingwu Li, John McLaughlin, Derek Hansen, Todd Kinsella, Tarikere L. Gururaja, Guillermo Godinez, Kathy White, Wayne Lang, David C.W. Lau, Alison Pan, Kristen A. Baltgalvis, Annabelle M. Friera, Raniel Alcantara, Mark Claypool, Yasumichi Hitoshi, Ira J. Smith, Baljit K. Singh, Henry Nguyen, Gerald Uy, Vadim Markovtsov, Kelly McCaughey, Wei Li, Tian-Qiang Sun, Simon J. Shaw, Gary Park, Donald G. Payan, Dane Goff, Yonchu Jenkins
Intermittent claudication is a form of exercise intolerance characterized by muscle pain during walking in patients with peripheral artery disease (PAD). Endothelial cell and muscle dysfunction are thought to be important contributors to the etiology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cb85cba9fc25c6fa558417bf842ee2d
https://europepmc.org/articles/PMC3989755/
https://europepmc.org/articles/PMC3989755/
Autor:
Wendy J. Fantl, Bingwei Lu, Tian-Qiang Sun, Jia-Jia Feng, Christoph Reinhard, Yuh Nung Jan, Lewis T. Williams
Publikováno v:
Nature Cell Biology. 3:628-636
Wnt signalling regulates beta-catenin-dependent developmental processes through the Dishevelled protein (Dsh). Dsh regulates two distinct pathways, one mediated by beta-catenin and the other by Jun kinase (JNK). We have purified a Dsh-associated kina
Autor:
April M. Nelson, Richard M. Harland, Lewis T. Williams, Christoph Reinhard, Wendy J. Fantl, Tian-Qiang Sun, Dong Yan, John B. Wallingford, Chie Sakanaka
Publikováno v:
Proceedings of the National Academy of Sciences. 98:3802-3807
Genetic studies have identified Drosophila Naked Cuticle (Nkd) as an antagonist of the canonical Wnt/β-catenin signaling pathway, but its mechanism of action remains obscure [Zeng, W., Wharton, K. A., Jr., Mack, J. A., Wang, K., Gadbaw, M., et al. (
Autor:
Rajinder Singh, Yonchu Jenkins, Rita Kohen, Gerald Uy, Rachel Basile, Benoit Viollet, Bruno Marcotte, Kristen A. Baltgalvis, Ira J. Smith, Yasumichi Hitoshi, Alexander Owyang, Wei Li, Vadim Markovtsov, Dane Goff, Marc Foretz, David C. Carroll, André Marette, Raniel Alcantara, Carmen Choy, Laszlo G. Boros, Guillermo Godinez, Xiang Xu, Kelly McCaughey, Alison Pan, Tarikere Gururaja, Lisa Gross, Yingwu Li, Kathy White, Todd Kinsella, Donald G. Payan, Hong Ren, Tian-Qiang Sun, Henry Nguyen, Taisei Kinoshita, Simon J. Shaw, Stephanie Yung, David J. Sweeny, Sarkiz D. Issakani, Marc-André Laplante
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 12, p e81870 (2013)
PLoS ONE, Vol 8, Iss 12, p e81870 (2013)
Modulation of mitochondrial function through inhibiting respiratory complex I activates a key sensor of cellular energy status, the 5'-AMP-activated protein kinase (AMPK). Activation of AMPK results in the mobilization of nutrient uptake and cataboli
Autor:
Rajinder Singh, Yingwu Li, Guillermo Godinez, Taisei Kinoshita, Alison Pan, Yonchu Jenkins, Kelly McCaughey, Dane Goff, Todd Kinsella, Henry Nguyen, Alexander Owyang, Yasumichi Hitoshi, Gerald Uy, Luke Boralsky, Kathy White, Vadim Markovtsov, Simon J. Shaw, Lisa Gross, Wei Q Li, Kristen A. Baltgalvis, Donald G. Payan, Raniel Alcantara, Carmen Choy, Tian-Qiang Sun, Tarikere L. Gururaja
Publikováno v:
The FASEB Journal. 27
Autor:
Jiandi, Zhang, Tian-Qiang, Sun
Publikováno v:
Vitamins and hormones. 80
Insulin receptor substrate 2 (IRS-2) is a key molecule in insulin signaling pathway, serving as an adaptor protein to insulin receptor to activate downstream kinase cascades, including MAP kinase and PI-3 kinase cascades. While reduced IRS-2 expressi