Zobrazeno 1 - 10
of 227
pro vyhledávání: '"Tian Yun Wang"'
Publikováno v:
Heliyon, Vol 10, Iss 5, Pp e26901- (2024)
The human cytomegalovirus major immediate early gene (CMV) promoter is currently the most preferred promoter for recombinant therapeutic proteins (RTPs) production in CHO cells. To enhance the production of RTPs, five synthetic enhancers including mu
Externí odkaz:
https://doaj.org/article/df250826291f4a588ea30c167798fbd7
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Recombinant therapeutic proteins (RTPs) are important parts of biopharmaceuticals. Chinese hamster ovary cells (CHO) have become the main cell hosts for the production of most RTPs approved for marketing because of their high-density suspension growt
Externí odkaz:
https://doaj.org/article/8a0c7067aee64c41a4451ed40fe44318
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Chinese hamster ovary (CHO) cells are currently the most widely used host cells for recombinant therapeutic protein (RTP) production. Currently, the RTP yields need to increase further to meet the market needs and reduce costs. In this study, three s
Externí odkaz:
https://doaj.org/article/b0e1dbd268e74ecead489c9366e7d334
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
In recent years, mammalian cells have become the primary host cells for the production of recombinant therapeutic proteins (RTPs). Despite that the expression of RTPs in mammalian cells can be improved by directly optimizing or engineering the expres
Externí odkaz:
https://doaj.org/article/89b5af4fbe0e4fdc94fed7a6c4df0c3f
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Recombinant protein production by mammalian cells is the initial step in the manufacture of many therapeutic proteins. Chinese hamster ovary (CHO) cells are the most common host system to produce recombinant therapeutic proteins (RTPs). However, it i
Externí odkaz:
https://doaj.org/article/2f9a3a2d30c74767947bc2f8c93d8c69
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
The generation of the stable, high-level recombinant protein-producing cell lines remains a significant challenge in the biopharmaceutical industry. Expression vector optimization is an effective strategy to increase transgene expression levels and s
Externí odkaz:
https://doaj.org/article/58a7fa3b2bf742c99d5c7b9c56f7b8c5
Publikováno v:
Journal of Diabetes Research, Vol 2022 (2022)
Aims. The present study is aimed at exploring the effects of sodium-glucose cotransporter-2 (SGLT-2) inhibitors on weight in type 2 diabetes mellitus (T2DM) and therapeutic regimen recommendations. Methods. 20,019 patients with T2DM were enrolled. Th
Externí odkaz:
https://doaj.org/article/15a8149f02644d7f8ebf6e6bc3705e22
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)
As the most widely used mammalian cell line, Chinese hamster ovary (CHO) cells can express various recombinant proteins with a post translational modification pattern similar to that of the proteins from human cells. During industrial production, cel
Externí odkaz:
https://doaj.org/article/f14b438497c949acaf686d8c97bdd03d
Publikováno v:
Frontiers in Nutrition, Vol 8 (2021)
Purpose: The study aimed to explore the effects of l-carnitine, acetyl-l-carnitine, and propionyl-l-carnitine on Body Mass in type 2 diabetes mellitus (T2DM) patients.Methods: Randomized controlled trial (RCT) studies of l-carnitine, acetyl-l-carniti
Externí odkaz:
https://doaj.org/article/4a51ce183fbb41c5a82cafecd71a7081
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)
At present, nearly 70% of recombinant therapeutic proteins (RTPs) are produced by Chinese hamster ovary (CHO) cells, and serum-free medium (SFM) is necessary for their culture to produce RTPs. In this review, the history and key components of SFM are
Externí odkaz:
https://doaj.org/article/5a36d8dc86774bbe85e235f0dddfbf5a