Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Tian Miao Ou"'
Publikováno v:
Molecules, Vol 27, Iss 10, p 3182 (2022)
The study on the mechanism and kinetics of mRNA degradation provides a new vision for chemical intervention on protein expression. The AU enrichment element (ARE) in mRNA 3′-UTR can be recognized and bound by the ARE binding protein (AU-rich Elemen
Externí odkaz:
https://doaj.org/article/02582613513d40fd8ef3158a1ad13c08
Autor:
Xiu-Cai Chen, Gui-Xue Tang, Jing Dai, Le-Tian Dai, Tian-Ying Wu, Wen-Wei Li, Tian-Miao Ou, Zhi-Shu Huang, Jia-Heng Tan, Shuo-Bin Chen
Publikováno v:
Journal of Medicinal Chemistry. 66:5171-5184
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::530a8caaf44c79f76a83392afcd96a89
https://doi.org/10.1021/acs.jmedchem.3c00094
https://doi.org/10.1021/acs.jmedchem.3c00094
Publikováno v:
Organic Letters. 25:1099-1103
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac0f99af18b689b3361d196ddf7848bc
https://doi.org/10.1021/acs.orglett.2c04343
https://doi.org/10.1021/acs.orglett.2c04343
Autor:
Mao-Lin Li, Jing-Mei Yuan, Hao Yuan, Bi-Han Wu, Shi-Liang Huang, Qing-Jiang Li, Tian-Miao Ou, Hong-Gen Wang, Jia-Heng Tan, Ding Li, Shuo-Bin Chen, Zhi-Shu Huang
Publikováno v:
Journal of Medicinal Chemistry. 65:12675-12700
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5266df396b14895123914afea378ad4
https://doi.org/10.1021/acs.jmedchem.2c00467
https://doi.org/10.1021/acs.jmedchem.2c00467
Autor:
Xin-Chen Jiang, Fang-Hai Tu, Li-Yuan Wei, Bo-Zheng Wang, Hao Yuan, Jing-Mei Yuan, Yong Rao, Shi-Liang Huang, Qing-Jiang Li, Tian-Miao Ou, Hong-Gen Wang, Jia-Heng Tan, Shuo-Bin Chen, Zhi-Shu Huang
Publikováno v:
Journal of Medicinal Chemistry. 65:12346-12366
The development of triple-negative breast cancer (TNBC) is highly associated with G-quadruplex (G4); thus, targeting G4 is a potential strategy for TNBC therapy. Because concomitant histone deacetylases (HDAC) inhibition could amplify the impact of G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69ee936cf4c88cd1bc4652ea3f6093fb
https://doi.org/10.1021/acs.jmedchem.2c01058
https://doi.org/10.1021/acs.jmedchem.2c01058
Publikováno v:
Biochemistry and Biophysics Reports, Vol 5, Iss C, Pp 439-447 (2016)
Environments surrounding G-rich sequences remarkably affect the conformations of these structures. A proper evaluation system mimicking the crowded environment in a cell with macromolecules should be developed to perform structural and functional stu
Externí odkaz:
https://doaj.org/article/91ce7703a2b149d5b3558cb87662fd4d
Autor:
Yun-Xia Xiong, Ai-Chun Chen, Pei-Fen Yao, De-Ying Zeng, Yu-Jing Lu, Jia-Heng Tan, Zhi-Shu Huang, Tian-Miao Ou
Publikováno v:
Biochemistry and Biophysics Reports, Vol 5, Iss C, Pp 346-352 (2016)
At present, wt1, a Wilms’ tumor suppressor gene, is recognized as a critical regulator of tumorigenesis and a potential therapeutic target. WT1 shows the ability to regulate the transcription of bcl-2 by binding to a GC-rich region in the promoter,
Externí odkaz:
https://doaj.org/article/2d3ff17de6274d4c82612f3924c1a30b
Autor:
Wei Long, Bo-Xin Zheng, Ying Li, Xuan-He Huang, Dan-Min Lin, Cui-Cui Chen, Jin-Qiang Hou, Tian-Miao Ou, Wing-Leung Wong, Kun Zhang, Yu-Jing Lu
Publikováno v:
Nucleic Acids Research. 50:1829-1848
DNA G4-structures from human c-MYC promoter and telomere are considered as important drug targets; however, the developing of small-molecule-based fluorescent binding ligands that are highly selective in targeting these G4-structures over other types
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbd6775f06f0cb51c1153088a65bf06d
https://doi.org/10.1093/nar/gkac090
https://doi.org/10.1093/nar/gkac090
Autor:
E. Emily Lin, Jia-Qiang Wu, Felix Schäfers, Xiao-Xuan Su, Ke-Feng Wang, Ji-Lin Li, Yunyun Chen, Xin Zhao, Huihui Ti, Qingjiang Li, Tian-Miao Ou, Frank Glorius, Honggen Wang
Publikováno v:
Communications Chemistry, Vol 2, Iss 1, Pp 1-1 (2019)
The previously published version of this Article contained errors in Fig. 1, where the B(MIDA) fragment was incorrectly labelled. These errors have been corrected in both the PDF and HTML versions of the Article.
Externí odkaz:
https://doaj.org/article/2b4fc59c781d4f418a3386696f81f461
Autor:
Shi-Liang Huang, Qi-Kun Yin, Jia-En Wang, Honggen Wang, Ding Li, Chen-Xi Wang, Jia-Heng Tan, Zhi-Shu Huang, Yao-Hao Xu, Yong Rao, Zi-Lin Zhang, Shuo-Bin Chen, Tian-Miao Ou, Jia-Li Tu, Qingjiang Li
Publikováno v:
Journal of Medicinal Chemistry. 63:9752-9772
DNA damage response (DDR) pathways are crucial for the survival of cancer cells and are attractive targets for cancer therapy. Bloom syndrome protein (BLM) is a DNA helicase that performs important roles in DDR pathways. Our previous study discovered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f21267762456ab0e27c8001c4c005bf
https://doi.org/10.1021/acs.jmedchem.0c00917
https://doi.org/10.1021/acs.jmedchem.0c00917