Zobrazeno 1 - 10 of 31 pro vyhledávání: '"Tian–Yun Fan"'
1
Akademický článek
Synthesis and biological evaluation of tricyclic matrinic derivatives as a class of novel anti-HCV agents
Autor: Sheng Tang, Zong-Gen Peng, Ying-Hong Li, Xin Zhang, Tian-Yun Fan, Jian-Dong Jiang, Yan-Xiang Wang, Dan-Qing Song
Publikováno v: Chemistry Central Journal, Vol 11, Iss 1, Pp 1-13 (2017)
Abstract Background 12N-benzyl matrinic acid analogues had been identified to be a novel scaffold of anti-HCV agents with a specific mechanism, and the representative compound 1 demonstrated a moderate anti-HCV activity. The intensive structure–act
Externí odkaz: https://doaj.org/article/3d38c76e33cd4b5ab6cb5f49deb458c4
Zobrazit plný text záznamu
2
Akademický článek
Evolution and Antibacterial Evaluation of 8-Hydroxy-cycloberberine Derivatives as a Novel Family of Antibacterial Agents Against MRSA
Autor: Yuan-Shuai Yang, Wei Wei, Xin-Xin Hu, Sheng Tang, Jing Pang, Xue-Fu You, Tian-Yun Fan, Yan-Xiang Wang, Dan-Qing Song
Publikováno v: Molecules, Vol 24, Iss 5, p 984 (2019)
Twenty-five new derivatives of 8-hydroxycycloberberine (1) were synthesized and evaluated for their activities against Gram-positive bacteria, taking 1 as the lead. Part of them displayed satisfactory antibacterial activities against methicillin-susc
Externí odkaz: https://doaj.org/article/404eb427fe1f4bf78764ded5459bdc75
Zobrazit plný text záznamu
3
Akademický článek
Synthesis and Identification of Novel Berberine Derivatives as Potent Inhibitors against TNF-α-Induced NF-κB Activation
Autor: Yan-Xiang Wang, Lu Liu, Qing-Xuan Zeng, Tian-Yun Fan, Jian-Dong Jiang, Hong-Bin Deng, Dan-Qing Song
Publikováno v: Molecules, Vol 22, Iss 8, p 1257 (2017)
Twenty-three new berberine (BBR) analogues defined on substituents of ring D were synthesized and evaluated for their activity for suppression of tumor necrosis factor (TNF)-α-induced nuclear factor (NF)-κB activation. Structure–activity relation
Externí odkaz: https://doaj.org/article/6f1d8ad4708e444886564524e8fd431c
Zobrazit plný text záznamu
6
Structure-activity relationship and biological evaluation of berberine derivatives as PCSK9 down-regulating agents
Autor: Xuelei Wang, Bin Hong, Li Wang, Xi-Xi Guo, Dan-Qing Song, Yuxin Yang, Tian-Yun Fan, Qingxuan Zeng, Yan-Xiang Wang, Wei Wei, Li-Ping Zhao
Publikováno v: Bioorganic chemistry. 113
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted protein and its deficiency markedly enhanced the survival rate of patient with cardiovascular diseases (CVDs). Forty berberine (BBR) derivatives were synthesized and evaluated for th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2fb87b2308d1e305f5b1c0f570f98de
https://pubmed.ncbi.nlm.nih.gov/34052738
Zobrazit plný text záznamu
7
Berberine Directly Targets the NEK7 Protein to Block the NEK7-NLRP3 Interaction and Exert Anti-inflammatory Activity
Autor: Ying-Hong Li, Yang Liu, Hongbin Deng, Qingxuan Zeng, Xi-Xi Guo, Xiaojia Liu, Yan-Xiang Wang, Dan-Qing Song, Sheng Tang, Wei Wei, Jian-Dong Jiang, Tian-Yun Fan
Publikováno v: Journal of medicinal chemistry. 64(1)
Berberine (BBR), a traditional Chinese medicine, has therapeutic effects on a variety of inflammation-related diseases, but its direct proteomic targets remain unknown. Using activity-based protein profiling, we first demonstrated that BBR directly t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25662273b45c5515d65943f5432f33ae
https://pubmed.ncbi.nlm.nih.gov/33440945
Zobrazit plný text záznamu
8
Synthesis and Structure–Activity Relationship of Palmatine Derivatives as a Novel Class of Antibacterial Agents against Helicobacter pylori
Autor: Jing Pang, Dan-Qing Song, Qingxuan Zeng, Xuefu You, Yan-Xiang Wang, Wei Wei, Xi-Xi Guo, Tian-Yun Fan
Publikováno v: Molecules
Volume 25
Issue 6
Molecules, Vol 25, Iss 6, p 1352 (2020)
Taking palmatine (PMT) as the lead, 20 new PMT derivatives were synthesized and examined for their antibacterial activities against six tested metronidazole (MTZ)-resistant Helicobacter pylori (H. pylori) strains. The structure&ndash
activity re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e610fde38b807e9110de776a4741d78c
Zobrazit plný text záznamu
9
Discovery of 9O-Substituted Palmatine Derivatives as a New Class of Anti-COL1A1 Agents Via Repressing TGF-β1/Smads and JAK1/STAT3 Pathways
Autor: Hongwei He, Dan-Qing Song, Zhihao Guo, Maoxu Ge, Tian-Yun Fan, Ying-Hong Li, Na Zhang
Publikováno v: Molecules, Vol 25, Iss 4, p 773 (2020)
Molecules
Volume 25
Issue 4
Twenty 9O-substituted palmatine derivatives were prepared and tested for their biological effect against collagen &alpha
1 (I) (COL1A1) promotor in human hepatic stellate LX-2 cells. The structure&minus
activity relationship (SAR) indicated
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb762c59557606f1627c5260517e87ea
https://www.mdpi.com/1420-3049/25/4/773
Zobrazit plný text záznamu
10
Synthesis and antibacterial evaluation of 13-substituted cycloberberine derivatives as a novel class of anti-MRSA agents
Autor: Xin–Xin Hu, Dan–Qing Song, Yuan–Shuai Yang, Xue–Fu You, Yan–Xiang Wang, Sheng Tang, Jing Pang, Tian–Yun Fan, Qing–Xuan Zen
Publikováno v: European Journal of Medicinal Chemistry. 157:877-886
A series of new 13-substituted cycloberberine (CBBR) derivatives were prepared and evaluated for their antibacterial activities against Gram-positive bacteria taking CBBR as the lead. Structure-activity relationship revealed that the introduction of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8b731e2fb4fd329c8f67a74852c3395
https://doi.org/10.1016/j.ejmech.2018.08.050
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje